A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination

DNA double strand breaks (DSBs) are mainly repaired via homologous recombination (HR) or nonhomologous end joining (NHEJ). These breaks pose severe threats to genome integrity but can also be necessary intermediates of normal cellular processes such as immunoglobulin class switch recombination (CSR)...

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Veröffentlicht in:	The Journal of experimental medicine 2013-11, Vol.210 (12), p.2503-2513
Hauptverfasser:	Enervald, Elin, Du, Likun, Visnes, Torkild, Björkman, Andrea, Lindgren, Emma, Wincent, Josephine, Borck, Guntram, Colleaux, Laurence, Cormier-Daire, Valerie, van Gent, Dik C, Pie, Juan, Puisac, Beatriz, de Miranda, Noel Fcc, Kracker, Sven, Hammarström, Lennart, de Villartay, Jean-Pierre, Durandy, Anne, Schoumans, Jacqueline, Ström, Lena, Pan-Hammarström, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent B-Lymphocytes - immunology B-Lymphocytes - metabolism Base Sequence Brief Definitive Report Case-Control Studies Cell Cycle Proteins - metabolism Cell Line Child Child, Preschool Chromosomal Proteins, Non-Histone - metabolism Cohesins De Lange Syndrome - genetics De Lange Syndrome - immunology De Lange Syndrome - metabolism DNA - genetics DNA - metabolism DNA Breaks, Double-Stranded DNA End-Joining Repair Genetics Heterozygote Human genetics Humans Immunoglobulin Class Switching Infant Intracellular Signaling Peptides and Proteins - metabolism Life Sciences Molecular Sequence Data Mutation Proteins - genetics Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Tumor Suppressor p53-Binding Protein 1
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