Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice
Central nervous system injuries are accompanied by scar formation. It has been difficult to delineate the precise role of the scar, as it is made by several different cell types, which may limit the damage but also inhibit axonal regrowth. We show that scarring by neural stem cell-derived astrocytes...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2013-11, Vol.342 (6158), p.637-640 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 640 |
|---|---|
| container_issue | 6158 |
| container_start_page | 637 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 342 |
| creator | Sabelström, Hanna Stenudd, Moa Réu, Pedro Dias, David O. Elfineh, Marta Zdunek, Sofia Damberg, Peter Göritz, Christian Frisén, Jonas |
| description | Central nervous system injuries are accompanied by scar formation. It has been difficult to delineate the precise role of the scar, as it is made by several different cell types, which may limit the damage but also inhibit axonal regrowth. We show that scarring by neural stem cell-derived astrocytes is required to restrict secondary enlargement of the lesion and further axonal loss after spinal cord injury. Moreover, neural stem cell progeny exerts a neurotrophic effect required for survival of neurons adjacent to the lesion. One distinct component of the glial scar, deriving from resident neural stem cells, is required for maintaining the integrity of the injured spinal cord. |
| doi_str_mv | 10.1126/science.1242576 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_525926</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>42620012</jstor_id><sourcerecordid>42620012</sourcerecordid><originalsourceid>FETCH-LOGICAL-c514t-7b5d27f5f83d5a8667cab77fa781c65631e673717e8d7ad682418c8ee2e0f4ae3</originalsourceid><addsrcrecordid>eNqF0cuLFDEQB-Agijuunj0pARG89G4enVT6uIyvhVHBXc8hk1RLxn6MSTey_72ZnXYEL54SUl9Cqn6EPOfsgnOhL7OPOHi84KIWCvQDsuKsUVUjmHxIVoxJXRkG6ow8yXnHWKk18jE5EzWHRghYkfAVcww4TPQzzsl19GbCnq6x6zItpSlFP9HbmPOM9K3r3Xekbgj3eBwK34w506t2wkRv9vFwsh5ToNfDbk53NA70U_T4lDxqXZfx2bKek2_v392uP1abLx-u11ebyiteTxVsVRDQqtbIoJzRGrzbArQODPdaaclRgwQOaAK4oE1pw3iDKJC1tUN5Tqrju_kX7uet3afYu3RnRxftcvSj7NAqoRqhi39z9Ps0_pxLt7aP2Zfe3YDjnC3XBrRRwOr_07o2QijdQKGv_qG7cU5lNPcKSkzSNEVdHpVPZYQJ29NvObOHbO2SrV2yLTdeLu_O2x7Dyf8Js4DXC3DZu65NbvAx_3XQgBJwcC-ObpenMZ3qtdCCMS7kbzrNtgM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1447576389</pqid></control><display><type>article</type><title>Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>American Association for the Advancement of Science</source><creator>Sabelström, Hanna ; Stenudd, Moa ; Réu, Pedro ; Dias, David O. ; Elfineh, Marta ; Zdunek, Sofia ; Damberg, Peter ; Göritz, Christian ; Frisén, Jonas</creator><creatorcontrib>Sabelström, Hanna ; Stenudd, Moa ; Réu, Pedro ; Dias, David O. ; Elfineh, Marta ; Zdunek, Sofia ; Damberg, Peter ; Göritz, Christian ; Frisén, Jonas</creatorcontrib><description>Central nervous system injuries are accompanied by scar formation. It has been difficult to delineate the precise role of the scar, as it is made by several different cell types, which may limit the damage but also inhibit axonal regrowth. We show that scarring by neural stem cell-derived astrocytes is required to restrict secondary enlargement of the lesion and further axonal loss after spinal cord injury. Moreover, neural stem cell progeny exerts a neurotrophic effect required for survival of neurons adjacent to the lesion. One distinct component of the glial scar, deriving from resident neural stem cells, is required for maintaining the integrity of the injured spinal cord.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1242576</identifier><identifier>PMID: 24179227</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Anatomy ; Animals ; Apoptosis ; Astrocytes ; Astrocytes - physiology ; Axons - physiology ; Biological and medical sciences ; Cell Survival ; Cells ; Cicatrix - pathology ; DNA damage ; Forkhead Transcription Factors - genetics ; Fundamental and applied biological sciences. Psychology ; Genes, ras ; Injuries ; Lesions ; Mice ; Mice, Mutant Strains ; Neural networks ; Neural stem cells ; Neural Stem Cells - physiology ; Neurons ; Neuroscience ; Rodents ; Scars ; Spinal cord ; Spinal cord injuries ; Spinal Cord Injuries - pathology ; Stem cells ; Tissues ; Vertebrates: nervous system and sense organs</subject><ispartof>Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6158), p.637-640</ispartof><rights>Copyright © 2013 American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-7b5d27f5f83d5a8667cab77fa781c65631e673717e8d7ad682418c8ee2e0f4ae3</citedby><cites>FETCH-LOGICAL-c514t-7b5d27f5f83d5a8667cab77fa781c65631e673717e8d7ad682418c8ee2e0f4ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/42620012$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/42620012$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,2882,2883,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27975277$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24179227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:127649718$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Sabelström, Hanna</creatorcontrib><creatorcontrib>Stenudd, Moa</creatorcontrib><creatorcontrib>Réu, Pedro</creatorcontrib><creatorcontrib>Dias, David O.</creatorcontrib><creatorcontrib>Elfineh, Marta</creatorcontrib><creatorcontrib>Zdunek, Sofia</creatorcontrib><creatorcontrib>Damberg, Peter</creatorcontrib><creatorcontrib>Göritz, Christian</creatorcontrib><creatorcontrib>Frisén, Jonas</creatorcontrib><title>Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Central nervous system injuries are accompanied by scar formation. It has been difficult to delineate the precise role of the scar, as it is made by several different cell types, which may limit the damage but also inhibit axonal regrowth. We show that scarring by neural stem cell-derived astrocytes is required to restrict secondary enlargement of the lesion and further axonal loss after spinal cord injury. Moreover, neural stem cell progeny exerts a neurotrophic effect required for survival of neurons adjacent to the lesion. One distinct component of the glial scar, deriving from resident neural stem cells, is required for maintaining the integrity of the injured spinal cord.</description><subject>Anatomy</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Astrocytes</subject><subject>Astrocytes - physiology</subject><subject>Axons - physiology</subject><subject>Biological and medical sciences</subject><subject>Cell Survival</subject><subject>Cells</subject><subject>Cicatrix - pathology</subject><subject>DNA damage</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, ras</subject><subject>Injuries</subject><subject>Lesions</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Neural networks</subject><subject>Neural stem cells</subject><subject>Neural Stem Cells - physiology</subject><subject>Neurons</subject><subject>Neuroscience</subject><subject>Rodents</subject><subject>Scars</subject><subject>Spinal cord</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - pathology</subject><subject>Stem cells</subject><subject>Tissues</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0cuLFDEQB-Agijuunj0pARG89G4enVT6uIyvhVHBXc8hk1RLxn6MSTey_72ZnXYEL54SUl9Cqn6EPOfsgnOhL7OPOHi84KIWCvQDsuKsUVUjmHxIVoxJXRkG6ow8yXnHWKk18jE5EzWHRghYkfAVcww4TPQzzsl19GbCnq6x6zItpSlFP9HbmPOM9K3r3Xekbgj3eBwK34w506t2wkRv9vFwsh5ToNfDbk53NA70U_T4lDxqXZfx2bKek2_v392uP1abLx-u11ebyiteTxVsVRDQqtbIoJzRGrzbArQODPdaaclRgwQOaAK4oE1pw3iDKJC1tUN5Tqrju_kX7uet3afYu3RnRxftcvSj7NAqoRqhi39z9Ps0_pxLt7aP2Zfe3YDjnC3XBrRRwOr_07o2QijdQKGv_qG7cU5lNPcKSkzSNEVdHpVPZYQJ29NvObOHbO2SrV2yLTdeLu_O2x7Dyf8Js4DXC3DZu65NbvAx_3XQgBJwcC-ObpenMZ3qtdCCMS7kbzrNtgM</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Sabelström, Hanna</creator><creator>Stenudd, Moa</creator><creator>Réu, Pedro</creator><creator>Dias, David O.</creator><creator>Elfineh, Marta</creator><creator>Zdunek, Sofia</creator><creator>Damberg, Peter</creator><creator>Göritz, Christian</creator><creator>Frisén, Jonas</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20131101</creationdate><title>Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice</title><author>Sabelström, Hanna ; Stenudd, Moa ; Réu, Pedro ; Dias, David O. ; Elfineh, Marta ; Zdunek, Sofia ; Damberg, Peter ; Göritz, Christian ; Frisén, Jonas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-7b5d27f5f83d5a8667cab77fa781c65631e673717e8d7ad682418c8ee2e0f4ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anatomy</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Astrocytes</topic><topic>Astrocytes - physiology</topic><topic>Axons - physiology</topic><topic>Biological and medical sciences</topic><topic>Cell Survival</topic><topic>Cells</topic><topic>Cicatrix - pathology</topic><topic>DNA damage</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, ras</topic><topic>Injuries</topic><topic>Lesions</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Neural networks</topic><topic>Neural stem cells</topic><topic>Neural Stem Cells - physiology</topic><topic>Neurons</topic><topic>Neuroscience</topic><topic>Rodents</topic><topic>Scars</topic><topic>Spinal cord</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - pathology</topic><topic>Stem cells</topic><topic>Tissues</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabelström, Hanna</creatorcontrib><creatorcontrib>Stenudd, Moa</creatorcontrib><creatorcontrib>Réu, Pedro</creatorcontrib><creatorcontrib>Dias, David O.</creatorcontrib><creatorcontrib>Elfineh, Marta</creatorcontrib><creatorcontrib>Zdunek, Sofia</creatorcontrib><creatorcontrib>Damberg, Peter</creatorcontrib><creatorcontrib>Göritz, Christian</creatorcontrib><creatorcontrib>Frisén, Jonas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabelström, Hanna</au><au>Stenudd, Moa</au><au>Réu, Pedro</au><au>Dias, David O.</au><au>Elfineh, Marta</au><au>Zdunek, Sofia</au><au>Damberg, Peter</au><au>Göritz, Christian</au><au>Frisén, Jonas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>342</volume><issue>6158</issue><spage>637</spage><epage>640</epage><pages>637-640</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Central nervous system injuries are accompanied by scar formation. It has been difficult to delineate the precise role of the scar, as it is made by several different cell types, which may limit the damage but also inhibit axonal regrowth. We show that scarring by neural stem cell-derived astrocytes is required to restrict secondary enlargement of the lesion and further axonal loss after spinal cord injury. Moreover, neural stem cell progeny exerts a neurotrophic effect required for survival of neurons adjacent to the lesion. One distinct component of the glial scar, deriving from resident neural stem cells, is required for maintaining the integrity of the injured spinal cord.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>24179227</pmid><doi>10.1126/science.1242576</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2013-11, Vol.342 (6158), p.637-640 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_525926 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Anatomy Animals Apoptosis Astrocytes Astrocytes - physiology Axons - physiology Biological and medical sciences Cell Survival Cells Cicatrix - pathology DNA damage Forkhead Transcription Factors - genetics Fundamental and applied biological sciences. Psychology Genes, ras Injuries Lesions Mice Mice, Mutant Strains Neural networks Neural stem cells Neural Stem Cells - physiology Neurons Neuroscience Rodents Scars Spinal cord Spinal cord injuries Spinal Cord Injuries - pathology Stem cells Tissues Vertebrates: nervous system and sense organs |
| title | Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T15%3A50%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Resident%20Neural%20Stem%20Cells%20Restrict%20Tissue%20Damage%20and%20Neuronal%20Loss%20After%20Spinal%20Cord%20Injury%20in%20Mice&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Sabelstr%C3%B6m,%20Hanna&rft.date=2013-11-01&rft.volume=342&rft.issue=6158&rft.spage=637&rft.epage=640&rft.pages=637-640&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.1242576&rft_dat=%3Cjstor_swepu%3E42620012%3C/jstor_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1447576389&rft_id=info:pmid/24179227&rft_jstor_id=42620012&rfr_iscdi=true |