Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure
Purpose To compare plasminogen activator inhibitor type1 (PAI-1) mutation rates in different groups of patients with the record of recurrent miscarriage (RM) or implantation failure (IF) with special emphasis on the number of missed pregnancies and/or implantation failures (RM ≥ 2, IF ≥ 2, RM + IF ≥...
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| Veröffentlicht in: | JOURNAL OF ASSISTED REPRODUCTION AND GENETICS 2014-01, Vol.31 (1), p.121-124 |
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| container_title | JOURNAL OF ASSISTED REPRODUCTION AND GENETICS |
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| creator | Khosravi, Farhad Zarei, Saeed Ahmadvand, Negah Akbarzadeh-Pasha, Zahra Savadi, Elham Zarnani, Amir-Hassan Sadeghi, Mohammad-Reza Jeddi-Tehrani, Mahmood |
| description | Purpose
To compare plasminogen activator inhibitor type1 (PAI-1) mutation rates in different groups of patients with the record of recurrent miscarriage (RM) or implantation failure (IF) with special emphasis on the number of missed pregnancies and/or implantation failures (RM ≥ 2, IF ≥ 2, RM + IF ≥ 2, RM ≥ 3, IF ≥ 3 and RM + IF ≥ 3).
Method
Case-control study from PCR products and RFLP data of DNA from blood of patients who referred to the infertility clinic including 595 patients (421 RM ≥ 2, 119 IF ≥ 2 and 55 RM + IF ≥ 2) as the case groups and 100 healthy women as the control group.
Results
All six different subgroups of patients showed increased frequencies of the mutant allele (4G) in comparison to the control group (
p
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| doi_str_mv | 10.1007/s10815-013-0125-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_525857</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1494305067</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-ade4c00ec5bd4d4daf1c83d2fa865136527a19320e3c3f3d695d4500de9dd57e3</originalsourceid><addsrcrecordid>eNp1Ut2K1jAQDaK466cP4I0UvPGmOmmaNr0RlsU_WPBGr0OaTLpZ2-QzaXfxIXxn021ddgUJIcPMmTOTwyHkJYW3FKB9lygIykugLN-Kl-IROaW8ZWXLGDzOMXBRQt2IE_IspSsA6ETFnpKTqqai6xp-Sn6fpRS0U7MLvuhxvkH0xXFUaXI-DDlWenbXag6xcP7S9W6NaJErWEzLvPUpbwrjrMWIfi7S0g8xLMdUBFtE1Eu8TU8uaRWjUwPeNrgpj_E7g1VuXCI-J0-sGhO-2N8D-f7xw7fzz-XF109fzs8uSs1BzKUyWGsA1Lw3dT7KUi2YqawSDaes4VWraMcqQKaZZabpuKk5gMHOGN4iO5By4003eFx6eYxuUvGXDMrJPfUjRyh5xUUW9EDeb_hcmdDo_J-oxgdtDyveXcohXEvWQUeZyARvdoIYfi6YZrnKgWNWAMOSJK27mgGHZp31-h_oVViiz3KsKEaBtrTOKLqhdAwpRbR3y1CQqznkZg6ZzSFXc8h1iVf3f3HX8dcNGVDtsuSSHzDeG_1f1j_UrMo5</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1493101714</pqid></control><display><type>article</type><title>Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><creator>Khosravi, Farhad ; Zarei, Saeed ; Ahmadvand, Negah ; Akbarzadeh-Pasha, Zahra ; Savadi, Elham ; Zarnani, Amir-Hassan ; Sadeghi, Mohammad-Reza ; Jeddi-Tehrani, Mahmood</creator><creatorcontrib>Khosravi, Farhad ; Zarei, Saeed ; Ahmadvand, Negah ; Akbarzadeh-Pasha, Zahra ; Savadi, Elham ; Zarnani, Amir-Hassan ; Sadeghi, Mohammad-Reza ; Jeddi-Tehrani, Mahmood</creatorcontrib><description>Purpose
To compare plasminogen activator inhibitor type1 (PAI-1) mutation rates in different groups of patients with the record of recurrent miscarriage (RM) or implantation failure (IF) with special emphasis on the number of missed pregnancies and/or implantation failures (RM ≥ 2, IF ≥ 2, RM + IF ≥ 2, RM ≥ 3, IF ≥ 3 and RM + IF ≥ 3).
Method
Case-control study from PCR products and RFLP data of DNA from blood of patients who referred to the infertility clinic including 595 patients (421 RM ≥ 2, 119 IF ≥ 2 and 55 RM + IF ≥ 2) as the case groups and 100 healthy women as the control group.
Results
All six different subgroups of patients showed increased frequencies of the mutant allele (4G) in comparison to the control group (
p
< 0.001) suggesting a role for PAI-1 mutation in RM and IF.
Conclusions
The different patient subgroups suffer similar rates of risk in developing RM and IF when compared to controls.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-013-0125-8</identifier><identifier>PMID: 24189965</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Abortion, Habitual - epidemiology ; Abortion, Habitual - genetics ; Adult ; Case-Control Studies ; Embryo Implantation - genetics ; Embryo Loss - epidemiology ; Embryo Loss - genetics ; Failure ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genetics ; Genotype & phenotype ; Gynecology ; Human Genetics ; Humans ; Infertility ; Medicine ; Medicine & Public Health ; Miscarriage ; Mutation ; Plasminogen Activator Inhibitor 1 - genetics ; Polymorphism ; Polymorphism, Restriction Fragment Length ; Preeclampsia ; Pregnancy ; Reproductive Medicine ; Research centers ; Young Adult</subject><ispartof>JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2014-01, Vol.31 (1), p.121-124</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-ade4c00ec5bd4d4daf1c83d2fa865136527a19320e3c3f3d695d4500de9dd57e3</citedby><cites>FETCH-LOGICAL-c508t-ade4c00ec5bd4d4daf1c83d2fa865136527a19320e3c3f3d695d4500de9dd57e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909138/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909138/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,550,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24189965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:128293394$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Khosravi, Farhad</creatorcontrib><creatorcontrib>Zarei, Saeed</creatorcontrib><creatorcontrib>Ahmadvand, Negah</creatorcontrib><creatorcontrib>Akbarzadeh-Pasha, Zahra</creatorcontrib><creatorcontrib>Savadi, Elham</creatorcontrib><creatorcontrib>Zarnani, Amir-Hassan</creatorcontrib><creatorcontrib>Sadeghi, Mohammad-Reza</creatorcontrib><creatorcontrib>Jeddi-Tehrani, Mahmood</creatorcontrib><title>Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure</title><title>JOURNAL OF ASSISTED REPRODUCTION AND GENETICS</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
To compare plasminogen activator inhibitor type1 (PAI-1) mutation rates in different groups of patients with the record of recurrent miscarriage (RM) or implantation failure (IF) with special emphasis on the number of missed pregnancies and/or implantation failures (RM ≥ 2, IF ≥ 2, RM + IF ≥ 2, RM ≥ 3, IF ≥ 3 and RM + IF ≥ 3).
Method
Case-control study from PCR products and RFLP data of DNA from blood of patients who referred to the infertility clinic including 595 patients (421 RM ≥ 2, 119 IF ≥ 2 and 55 RM + IF ≥ 2) as the case groups and 100 healthy women as the control group.
Results
All six different subgroups of patients showed increased frequencies of the mutant allele (4G) in comparison to the control group (
p
< 0.001) suggesting a role for PAI-1 mutation in RM and IF.
Conclusions
The different patient subgroups suffer similar rates of risk in developing RM and IF when compared to controls.</description><subject>Abortion, Habitual - epidemiology</subject><subject>Abortion, Habitual - genetics</subject><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Embryo Implantation - genetics</subject><subject>Embryo Loss - epidemiology</subject><subject>Embryo Loss - genetics</subject><subject>Failure</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Genotype & phenotype</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Infertility</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Miscarriage</subject><subject>Mutation</subject><subject>Plasminogen Activator Inhibitor 1 - genetics</subject><subject>Polymorphism</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Reproductive Medicine</subject><subject>Research centers</subject><subject>Young Adult</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><recordid>eNp1Ut2K1jAQDaK466cP4I0UvPGmOmmaNr0RlsU_WPBGr0OaTLpZ2-QzaXfxIXxn021ddgUJIcPMmTOTwyHkJYW3FKB9lygIykugLN-Kl-IROaW8ZWXLGDzOMXBRQt2IE_IspSsA6ETFnpKTqqai6xp-Sn6fpRS0U7MLvuhxvkH0xXFUaXI-DDlWenbXag6xcP7S9W6NaJErWEzLvPUpbwrjrMWIfi7S0g8xLMdUBFtE1Eu8TU8uaRWjUwPeNrgpj_E7g1VuXCI-J0-sGhO-2N8D-f7xw7fzz-XF109fzs8uSs1BzKUyWGsA1Lw3dT7KUi2YqawSDaes4VWraMcqQKaZZabpuKk5gMHOGN4iO5By4003eFx6eYxuUvGXDMrJPfUjRyh5xUUW9EDeb_hcmdDo_J-oxgdtDyveXcohXEvWQUeZyARvdoIYfi6YZrnKgWNWAMOSJK27mgGHZp31-h_oVViiz3KsKEaBtrTOKLqhdAwpRbR3y1CQqznkZg6ZzSFXc8h1iVf3f3HX8dcNGVDtsuSSHzDeG_1f1j_UrMo5</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Khosravi, Farhad</creator><creator>Zarei, Saeed</creator><creator>Ahmadvand, Negah</creator><creator>Akbarzadeh-Pasha, Zahra</creator><creator>Savadi, Elham</creator><creator>Zarnani, Amir-Hassan</creator><creator>Sadeghi, Mohammad-Reza</creator><creator>Jeddi-Tehrani, Mahmood</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20140101</creationdate><title>Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure</title><author>Khosravi, Farhad ; Zarei, Saeed ; Ahmadvand, Negah ; Akbarzadeh-Pasha, Zahra ; Savadi, Elham ; Zarnani, Amir-Hassan ; Sadeghi, Mohammad-Reza ; Jeddi-Tehrani, Mahmood</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-ade4c00ec5bd4d4daf1c83d2fa865136527a19320e3c3f3d695d4500de9dd57e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abortion, Habitual - epidemiology</topic><topic>Abortion, Habitual - genetics</topic><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Embryo Implantation - genetics</topic><topic>Embryo Loss - epidemiology</topic><topic>Embryo Loss - genetics</topic><topic>Failure</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Genotype & phenotype</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Infertility</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Miscarriage</topic><topic>Mutation</topic><topic>Plasminogen Activator Inhibitor 1 - genetics</topic><topic>Polymorphism</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Reproductive Medicine</topic><topic>Research centers</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khosravi, Farhad</creatorcontrib><creatorcontrib>Zarei, Saeed</creatorcontrib><creatorcontrib>Ahmadvand, Negah</creatorcontrib><creatorcontrib>Akbarzadeh-Pasha, Zahra</creatorcontrib><creatorcontrib>Savadi, Elham</creatorcontrib><creatorcontrib>Zarnani, Amir-Hassan</creatorcontrib><creatorcontrib>Sadeghi, Mohammad-Reza</creatorcontrib><creatorcontrib>Jeddi-Tehrani, Mahmood</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>JOURNAL OF ASSISTED REPRODUCTION AND GENETICS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khosravi, Farhad</au><au>Zarei, Saeed</au><au>Ahmadvand, Negah</au><au>Akbarzadeh-Pasha, Zahra</au><au>Savadi, Elham</au><au>Zarnani, Amir-Hassan</au><au>Sadeghi, Mohammad-Reza</au><au>Jeddi-Tehrani, Mahmood</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure</atitle><jtitle>JOURNAL OF ASSISTED REPRODUCTION AND GENETICS</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>31</volume><issue>1</issue><spage>121</spage><epage>124</epage><pages>121-124</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Purpose
To compare plasminogen activator inhibitor type1 (PAI-1) mutation rates in different groups of patients with the record of recurrent miscarriage (RM) or implantation failure (IF) with special emphasis on the number of missed pregnancies and/or implantation failures (RM ≥ 2, IF ≥ 2, RM + IF ≥ 2, RM ≥ 3, IF ≥ 3 and RM + IF ≥ 3).
Method
Case-control study from PCR products and RFLP data of DNA from blood of patients who referred to the infertility clinic including 595 patients (421 RM ≥ 2, 119 IF ≥ 2 and 55 RM + IF ≥ 2) as the case groups and 100 healthy women as the control group.
Results
All six different subgroups of patients showed increased frequencies of the mutant allele (4G) in comparison to the control group (
p
< 0.001) suggesting a role for PAI-1 mutation in RM and IF.
Conclusions
The different patient subgroups suffer similar rates of risk in developing RM and IF when compared to controls.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24189965</pmid><doi>10.1007/s10815-013-0125-8</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online |
| subjects | Abortion, Habitual - epidemiology Abortion, Habitual - genetics Adult Case-Control Studies Embryo Implantation - genetics Embryo Loss - epidemiology Embryo Loss - genetics Failure Female Genetic Association Studies Genetic Predisposition to Disease Genetics Genotype & phenotype Gynecology Human Genetics Humans Infertility Medicine Medicine & Public Health Miscarriage Mutation Plasminogen Activator Inhibitor 1 - genetics Polymorphism Polymorphism, Restriction Fragment Length Preeclampsia Pregnancy Reproductive Medicine Research centers Young Adult |
| title | Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure |
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