Cognitive decline is mediated by gray matter changes during middle age

Abstract The present theoretical framework of Alzheimer's disease proposes that pathophysiological changes occur 10–20 years before the diagnosis of dementia. We addressed the question of how age-related changes in gray matter mediate the cognitive performance during middle age. Eighty-two part...

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Veröffentlicht in:	Neurobiology of aging 2014-05, Vol.35 (5), p.1086-1094
Hauptverfasser:	Ferreira, Daniel, Molina, Yaiza, Machado, Alejandra, Westman, Eric, Wahlund, Lars-Olof, Nieto, Antonieta, Correia, Rut, Junqué, Carme, Díaz-Flores, Lucio, Barroso, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aging - pathology Aging - psychology Bootstrapping analyses Cognition - physiology Cognition Disorders - diagnosis Cognition Disorders - pathology Cognitive decline Early aging Frontal Lobe - pathology Gray matter changes Hierarchical regression analyses Humans Internal Medicine Male Mediation effect Middle age Middle Aged Neurology Neuropsychological Tests
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