Diabetes, markers of brain pathology and cognitive function: the Age, Gene/Environment Susceptibility-Reykjavik Study
We investigated whether, and the extent to which, vascular and degenerative lesions in the brain mediate the association of diabetes with poor cognitive performance. This cross-sectional study included 4,206 participants (age > 65 years; 57.8% women) of the Age, Gene/Environment Susceptibility-Re...
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| Veröffentlicht in: | Annals of neurology 2014-01, Vol.75 (1), p.138-146 |
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| creator | Qiu, Chengxuan Sigurdsson, Sigurdur Zhang, Qian Jonsdottir, Maria K Kjartansson, Olafur Eiriksdottir, Gudny Garcia, Melissa E Harris, Tamara B van Buchem, Mark A Gudnason, Vilmundur Launer, Lenore J |
| description | We investigated whether, and the extent to which, vascular and degenerative lesions in the brain mediate the association of diabetes with poor cognitive performance.
This cross-sectional study included 4,206 participants (age > 65 years; 57.8% women) of the Age, Gene/Environment Susceptibility-Reykjavik Study. Data were collected through interview, clinical examination, psychological testing, and laboratory tests. The composite scores on memory, information-processing speed, and executive function were derived from a cognitive test battery. Markers of cerebral macrovascular (cortical infarcts), microvascular (subcortical infarcts, cerebral microbleeds, and higher white matter lesion volume), and neurodegenerative (lower gray matter, normal white matter, and total brain tissue volumes) processes were assessed on magnetic resonance images. Mediation models were employed to test the mediating effect of brain lesions on the association of diabetes with cognitive performance controlling for potential confounders.
There were 462 (11.0%) persons with diabetes. Diabetes was significantly associated with lower scores on processing speed and executive function, but not with memory function. Diabetes was significantly associated with all markers of brain pathology. All of these markers were significantly associated with lower scores on memory, processing speed, and executive function. Formal mediation tests suggested that markers of cerebrovascular and degenerative pathology significantly mediated the associations of diabetes with processing speed and executive function.
Diabetes is associated with poor performance on cognitive tests of information-processing speed and executive function. The association is largely mediated by markers of both neurodegeneration and cerebrovascular disease. Older people with diabetes should be monitored for cognitive problems and brain lesions. |
| doi_str_mv | 10.1002/ana.24063 |
| format | Article |
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This cross-sectional study included 4,206 participants (age > 65 years; 57.8% women) of the Age, Gene/Environment Susceptibility-Reykjavik Study. Data were collected through interview, clinical examination, psychological testing, and laboratory tests. The composite scores on memory, information-processing speed, and executive function were derived from a cognitive test battery. Markers of cerebral macrovascular (cortical infarcts), microvascular (subcortical infarcts, cerebral microbleeds, and higher white matter lesion volume), and neurodegenerative (lower gray matter, normal white matter, and total brain tissue volumes) processes were assessed on magnetic resonance images. Mediation models were employed to test the mediating effect of brain lesions on the association of diabetes with cognitive performance controlling for potential confounders.
There were 462 (11.0%) persons with diabetes. Diabetes was significantly associated with lower scores on processing speed and executive function, but not with memory function. Diabetes was significantly associated with all markers of brain pathology. All of these markers were significantly associated with lower scores on memory, processing speed, and executive function. Formal mediation tests suggested that markers of cerebrovascular and degenerative pathology significantly mediated the associations of diabetes with processing speed and executive function.
Diabetes is associated with poor performance on cognitive tests of information-processing speed and executive function. The association is largely mediated by markers of both neurodegeneration and cerebrovascular disease. Older people with diabetes should be monitored for cognitive problems and brain lesions.</description><identifier>ISSN: 0364-5134</identifier><identifier>ISSN: 1531-8249</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.24063</identifier><identifier>PMID: 24243491</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Aged, 80 and over ; Aging - genetics ; Aging - metabolism ; Aging - pathology ; Brain - pathology ; Brain Diseases - epidemiology ; Brain Diseases - genetics ; Brain Diseases - pathology ; Cognition - physiology ; Cognition Disorders - epidemiology ; Cognition Disorders - genetics ; Cognition Disorders - pathology ; Cohort Studies ; Cross-Sectional Studies ; Diabetes Mellitus - epidemiology ; Diabetes Mellitus - genetics ; Diabetes Mellitus - pathology ; Disease Susceptibility - metabolism ; Disease Susceptibility - pathology ; Female ; Humans ; Iceland - epidemiology ; Male</subject><ispartof>Annals of neurology, 2014-01, Vol.75 (1), p.138-146</ispartof><rights>2013 American Neurological Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c375t-90bd3c2dce2bad3d8480443c257a60b7b14d50dc47094cc8985230818d6354163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24243491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-102490$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:128419487$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Qiu, Chengxuan</creatorcontrib><creatorcontrib>Sigurdsson, Sigurdur</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Jonsdottir, Maria K</creatorcontrib><creatorcontrib>Kjartansson, Olafur</creatorcontrib><creatorcontrib>Eiriksdottir, Gudny</creatorcontrib><creatorcontrib>Garcia, Melissa E</creatorcontrib><creatorcontrib>Harris, Tamara B</creatorcontrib><creatorcontrib>van Buchem, Mark A</creatorcontrib><creatorcontrib>Gudnason, Vilmundur</creatorcontrib><creatorcontrib>Launer, Lenore J</creatorcontrib><title>Diabetes, markers of brain pathology and cognitive function: the Age, Gene/Environment Susceptibility-Reykjavik Study</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>We investigated whether, and the extent to which, vascular and degenerative lesions in the brain mediate the association of diabetes with poor cognitive performance.
This cross-sectional study included 4,206 participants (age > 65 years; 57.8% women) of the Age, Gene/Environment Susceptibility-Reykjavik Study. Data were collected through interview, clinical examination, psychological testing, and laboratory tests. The composite scores on memory, information-processing speed, and executive function were derived from a cognitive test battery. Markers of cerebral macrovascular (cortical infarcts), microvascular (subcortical infarcts, cerebral microbleeds, and higher white matter lesion volume), and neurodegenerative (lower gray matter, normal white matter, and total brain tissue volumes) processes were assessed on magnetic resonance images. Mediation models were employed to test the mediating effect of brain lesions on the association of diabetes with cognitive performance controlling for potential confounders.
There were 462 (11.0%) persons with diabetes. Diabetes was significantly associated with lower scores on processing speed and executive function, but not with memory function. Diabetes was significantly associated with all markers of brain pathology. All of these markers were significantly associated with lower scores on memory, processing speed, and executive function. Formal mediation tests suggested that markers of cerebrovascular and degenerative pathology significantly mediated the associations of diabetes with processing speed and executive function.
Diabetes is associated with poor performance on cognitive tests of information-processing speed and executive function. The association is largely mediated by markers of both neurodegeneration and cerebrovascular disease. Older people with diabetes should be monitored for cognitive problems and brain lesions.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - genetics</subject><subject>Aging - metabolism</subject><subject>Aging - pathology</subject><subject>Brain - pathology</subject><subject>Brain Diseases - epidemiology</subject><subject>Brain Diseases - genetics</subject><subject>Brain Diseases - pathology</subject><subject>Cognition - physiology</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - genetics</subject><subject>Cognition Disorders - pathology</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diabetes Mellitus - genetics</subject><subject>Diabetes Mellitus - pathology</subject><subject>Disease Susceptibility - metabolism</subject><subject>Disease Susceptibility - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Iceland - epidemiology</subject><subject>Male</subject><issn>0364-5134</issn><issn>1531-8249</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kktvEzEUhS0EoqGw4A8gL0HKtH7OgwVS1JYWqVIlCmwtj-dm4mZiB9sTNP8el6QVXXRl6_rzucfXB6H3lJxQQtipdvqECVLyF2hGJadFzUTzEs0IL0UhKRdH6E2Md4SQpqTkNTpiggkuGjpD47nVLSSIc7zRYQ0hYr_EbdDW4a1OKz_4fsLaddj43tlkd4CXozPJevcZpxXgRQ9zfAkOTi_czgbvNuASvh2jgW2yrR1smorvMK3v9M6u8W0au-kterXUQ4R3h_UY_fx68ePsqri-ufx2trguDK9kKhrSdtywzgBrdce7WtREiFyRlS5JW7VUdJJ0RlSkEcbUTS0ZJzWtu5JLQUt-jIq9bvwD27FV22DzKyfltVWH0jrvQEkmJReZnz_Ln9tfC-VDr-KoKMkDJhn_ssczu4Fs06Wghye3np44u1K93ykhBWGcZ4GPB4Hgf48Qk9rYPLdh0A78GBUVTUN5Vcl7a5_2qAk-xgDLxzaUqPsUqJwC9S8Fmf3wv69H8uHb-V_nXa_A</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Qiu, Chengxuan</creator><creator>Sigurdsson, Sigurdur</creator><creator>Zhang, Qian</creator><creator>Jonsdottir, Maria K</creator><creator>Kjartansson, Olafur</creator><creator>Eiriksdottir, Gudny</creator><creator>Garcia, Melissa E</creator><creator>Harris, Tamara B</creator><creator>van Buchem, Mark A</creator><creator>Gudnason, Vilmundur</creator><creator>Launer, Lenore J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DG7</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>201401</creationdate><title>Diabetes, markers of brain pathology and cognitive function: the Age, Gene/Environment Susceptibility-Reykjavik Study</title><author>Qiu, Chengxuan ; Sigurdsson, Sigurdur ; Zhang, Qian ; Jonsdottir, Maria K ; Kjartansson, Olafur ; Eiriksdottir, Gudny ; Garcia, Melissa E ; Harris, Tamara B ; van Buchem, Mark A ; Gudnason, Vilmundur ; Launer, Lenore J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-90bd3c2dce2bad3d8480443c257a60b7b14d50dc47094cc8985230818d6354163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - genetics</topic><topic>Aging - metabolism</topic><topic>Aging - pathology</topic><topic>Brain - pathology</topic><topic>Brain Diseases - epidemiology</topic><topic>Brain Diseases - genetics</topic><topic>Brain Diseases - pathology</topic><topic>Cognition - physiology</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - genetics</topic><topic>Cognition Disorders - pathology</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Diabetes Mellitus - genetics</topic><topic>Diabetes Mellitus - pathology</topic><topic>Disease Susceptibility - metabolism</topic><topic>Disease Susceptibility - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Iceland - epidemiology</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qiu, Chengxuan</creatorcontrib><creatorcontrib>Sigurdsson, Sigurdur</creatorcontrib><creatorcontrib>Zhang, Qian</creatorcontrib><creatorcontrib>Jonsdottir, Maria K</creatorcontrib><creatorcontrib>Kjartansson, Olafur</creatorcontrib><creatorcontrib>Eiriksdottir, Gudny</creatorcontrib><creatorcontrib>Garcia, Melissa E</creatorcontrib><creatorcontrib>Harris, Tamara B</creatorcontrib><creatorcontrib>van Buchem, Mark A</creatorcontrib><creatorcontrib>Gudnason, Vilmundur</creatorcontrib><creatorcontrib>Launer, Lenore J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Stockholms universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qiu, Chengxuan</au><au>Sigurdsson, Sigurdur</au><au>Zhang, Qian</au><au>Jonsdottir, Maria K</au><au>Kjartansson, Olafur</au><au>Eiriksdottir, Gudny</au><au>Garcia, Melissa E</au><au>Harris, Tamara B</au><au>van Buchem, Mark A</au><au>Gudnason, Vilmundur</au><au>Launer, Lenore J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetes, markers of brain pathology and cognitive function: the Age, Gene/Environment Susceptibility-Reykjavik Study</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2014-01</date><risdate>2014</risdate><volume>75</volume><issue>1</issue><spage>138</spage><epage>146</epage><pages>138-146</pages><issn>0364-5134</issn><issn>1531-8249</issn><eissn>1531-8249</eissn><abstract>We investigated whether, and the extent to which, vascular and degenerative lesions in the brain mediate the association of diabetes with poor cognitive performance.
This cross-sectional study included 4,206 participants (age > 65 years; 57.8% women) of the Age, Gene/Environment Susceptibility-Reykjavik Study. Data were collected through interview, clinical examination, psychological testing, and laboratory tests. The composite scores on memory, information-processing speed, and executive function were derived from a cognitive test battery. Markers of cerebral macrovascular (cortical infarcts), microvascular (subcortical infarcts, cerebral microbleeds, and higher white matter lesion volume), and neurodegenerative (lower gray matter, normal white matter, and total brain tissue volumes) processes were assessed on magnetic resonance images. Mediation models were employed to test the mediating effect of brain lesions on the association of diabetes with cognitive performance controlling for potential confounders.
There were 462 (11.0%) persons with diabetes. Diabetes was significantly associated with lower scores on processing speed and executive function, but not with memory function. Diabetes was significantly associated with all markers of brain pathology. All of these markers were significantly associated with lower scores on memory, processing speed, and executive function. Formal mediation tests suggested that markers of cerebrovascular and degenerative pathology significantly mediated the associations of diabetes with processing speed and executive function.
Diabetes is associated with poor performance on cognitive tests of information-processing speed and executive function. The association is largely mediated by markers of both neurodegeneration and cerebrovascular disease. Older people with diabetes should be monitored for cognitive problems and brain lesions.</abstract><cop>United States</cop><pmid>24243491</pmid><doi>10.1002/ana.24063</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Aging - genetics Aging - metabolism Aging - pathology Brain - pathology Brain Diseases - epidemiology Brain Diseases - genetics Brain Diseases - pathology Cognition - physiology Cognition Disorders - epidemiology Cognition Disorders - genetics Cognition Disorders - pathology Cohort Studies Cross-Sectional Studies Diabetes Mellitus - epidemiology Diabetes Mellitus - genetics Diabetes Mellitus - pathology Disease Susceptibility - metabolism Disease Susceptibility - pathology Female Humans Iceland - epidemiology Male |
| title | Diabetes, markers of brain pathology and cognitive function: the Age, Gene/Environment Susceptibility-Reykjavik Study |
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