Screening Preeclamptic Cord Plasma for Proteins Associated with Decreased Breast Cancer Susceptibility
Preeclampsia, a complication of pregnancy characterized by hypertension and proteinuria, has been found to reduce the subsequent risk for breast cancer in female offspring. As this pro- tective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic...
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| Veröffentlicht in: | GENOMICS PROTEOMICS & BIOINFORMATICS 2013-12, Vol.11 (6), p.335-344 |
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| creator | Low, Hoi Pang Tiwari, Ashutosh Janjanam, Jagadeesh Qiu, Li Chang, Chien-I Strohsnitter, William C. Norwitz, Errol R. Tam, Sun W. Evans, James E. Green, Karin M. Paulo, Joao A. Lambe, Mats Hsieh, Chung-Cheng |
| description | Preeclampsia, a complication of pregnancy characterized by hypertension and proteinuria, has been found to reduce the subsequent risk for breast cancer in female offspring. As this pro- tective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic profiles of umbilical cord blood plasma between preeclamptic and normotensive pregnancies were compared. Umbilical cord plasma samples, depleted of 14 abundant proteins, were subjected to proteomic analysis using the quantitative method of nanoACQUITY ultra performance liquid chromatography-mass spectrometry with elevated energy mode of acquisitionE （NanoUPLC-MSE）. Sixty-nine differentially expressed proteins were identified, of which 15 and 6 proteins were only detected in preeclamptic and normotensive pregnancies, respectively.Additionally, expression of 8 proteins （gelsolin, complement C5, keratin type I cytoskeletal 10, pigment epithelium-derived factor, complement factor B, complement component C7, hemoglobin subunit gamma-2 and alpha-fetoprotein） were up-regulated in preeclampsia with a fold change of 1〉 2.0 when compared to normotensive pregnancies. The identification of alpha-fetoprotein in pre- eclamptic umbilical cord blood plasma supported the validity of this screen as alpha-fetoprotein has anti-estrogenic properties and has previously been linked to preeclampsia as well as a reduced breast cancer risk. The findings of this pilot study may provide new insights into the mechanistic link between preeclampsia and potentially reduced breast cancer susceptibility in adult life. |
| doi_str_mv | 10.1016/j.gpb.2013.09.009 |
| format | Article |
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As this pro- tective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic profiles of umbilical cord blood plasma between preeclamptic and normotensive pregnancies were compared. Umbilical cord plasma samples, depleted of 14 abundant proteins, were subjected to proteomic analysis using the quantitative method of nanoACQUITY ultra performance liquid chromatography-mass spectrometry with elevated energy mode of acquisitionE （NanoUPLC-MSE）. Sixty-nine differentially expressed proteins were identified, of which 15 and 6 proteins were only detected in preeclamptic and normotensive pregnancies, respectively.Additionally, expression of 8 proteins （gelsolin, complement C5, keratin type I cytoskeletal 10, pigment epithelium-derived factor, complement factor B, complement component C7, hemoglobin subunit gamma-2 and alpha-fetoprotein） were up-regulated in preeclampsia with a fold change of 1〉 2.0 when compared to normotensive pregnancies. The identification of alpha-fetoprotein in pre- eclamptic umbilical cord blood plasma supported the validity of this screen as alpha-fetoprotein has anti-estrogenic properties and has previously been linked to preeclampsia as well as a reduced breast cancer risk. The findings of this pilot study may provide new insights into the mechanistic link between preeclampsia and potentially reduced breast cancer susceptibility in adult life.</description><identifier>ISSN: 1672-0229</identifier><identifier>EISSN: 2210-3244</identifier><identifier>DOI: 10.1016/j.gpb.2013.09.009</identifier><identifier>PMID: 24296084</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>adults ; analysis ; Biomarkers ; blood ; blood plasma ; Blood Proteins ; Blood Proteins - analysis ; breast neoplasms ; Breast Neoplasms - blood ; Breast Neoplasms - chemistry ; chemistry ; Chromatography, Liquid ; complement ; cytoskeleton ; Disease Susceptibility ; energy ; Female ; Fetal Blood ; Fetal Blood - chemistry ; Fetal Blood - metabolism ; gene expression regulation ; hemoglobin ; Humans ; hypertension ; Intrauterine environment ; keratin ; Mass Spectrometry ; metabolism ; Original Research ; Pilot Projects ; pre-eclampsia ; Pre-Eclampsia - blood ; Preeclampsia ; Pregnancy ; Prenatal ; progeny ; protective effect ; protein synthesis ; proteinuria ; Proteomics ; risk ; screening ; spectroscopy ; umbilical cord ; 乳腺癌 ; 先兆 ; 子痫 ; 特异性蛋白质 ; 相关蛋白 ; 等离子 ; 色素上皮衍生因子 ; 超高效液相色谱</subject><ispartof>GENOMICS PROTEOMICS & BIOINFORMATICS, 2013-12, Vol.11 (6), p.335-344</ispartof><rights>2013</rights><rights>Copyright © 2013. Production and hosting by Elsevier Ltd.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2013 Beijing Institute of Genomics, Chinese Academy of Sciences and Genetics Society of China. Production and hosting by Elsevier B.V. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5621-a8942f9f36fbb76bd6b209541a2ece5aa540a4072157a97406a94d7d0a62669a3</citedby><cites>FETCH-LOGICAL-c5621-a8942f9f36fbb76bd6b209541a2ece5aa540a4072157a97406a94d7d0a62669a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/86775X/86775X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357835/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1672022913001198$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,3537,27901,27902,53766,53768,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24296084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:224296084$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Low, Hoi Pang</creatorcontrib><creatorcontrib>Tiwari, Ashutosh</creatorcontrib><creatorcontrib>Janjanam, Jagadeesh</creatorcontrib><creatorcontrib>Qiu, Li</creatorcontrib><creatorcontrib>Chang, Chien-I</creatorcontrib><creatorcontrib>Strohsnitter, William C.</creatorcontrib><creatorcontrib>Norwitz, Errol R.</creatorcontrib><creatorcontrib>Tam, Sun W.</creatorcontrib><creatorcontrib>Evans, James E.</creatorcontrib><creatorcontrib>Green, Karin M.</creatorcontrib><creatorcontrib>Paulo, Joao A.</creatorcontrib><creatorcontrib>Lambe, Mats</creatorcontrib><creatorcontrib>Hsieh, Chung-Cheng</creatorcontrib><title>Screening Preeclamptic Cord Plasma for Proteins Associated with Decreased Breast Cancer Susceptibility</title><title>GENOMICS PROTEOMICS & BIOINFORMATICS</title><addtitle>Genomics Proteomics ＆ Bioinformatics</addtitle><description>Preeclampsia, a complication of pregnancy characterized by hypertension and proteinuria, has been found to reduce the subsequent risk for breast cancer in female offspring. As this pro- tective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic profiles of umbilical cord blood plasma between preeclamptic and normotensive pregnancies were compared. Umbilical cord plasma samples, depleted of 14 abundant proteins, were subjected to proteomic analysis using the quantitative method of nanoACQUITY ultra performance liquid chromatography-mass spectrometry with elevated energy mode of acquisitionE （NanoUPLC-MSE）. Sixty-nine differentially expressed proteins were identified, of which 15 and 6 proteins were only detected in preeclamptic and normotensive pregnancies, respectively.Additionally, expression of 8 proteins （gelsolin, complement C5, keratin type I cytoskeletal 10, pigment epithelium-derived factor, complement factor B, complement component C7, hemoglobin subunit gamma-2 and alpha-fetoprotein） were up-regulated in preeclampsia with a fold change of 1〉 2.0 when compared to normotensive pregnancies. The identification of alpha-fetoprotein in pre- eclamptic umbilical cord blood plasma supported the validity of this screen as alpha-fetoprotein has anti-estrogenic properties and has previously been linked to preeclampsia as well as a reduced breast cancer risk. The findings of this pilot study may provide new insights into the mechanistic link between preeclampsia and potentially reduced breast cancer susceptibility in adult life.</description><subject>adults</subject><subject>analysis</subject><subject>Biomarkers</subject><subject>blood</subject><subject>blood plasma</subject><subject>Blood Proteins</subject><subject>Blood Proteins - analysis</subject><subject>breast neoplasms</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - chemistry</subject><subject>chemistry</subject><subject>Chromatography, Liquid</subject><subject>complement</subject><subject>cytoskeleton</subject><subject>Disease Susceptibility</subject><subject>energy</subject><subject>Female</subject><subject>Fetal Blood</subject><subject>Fetal Blood - chemistry</subject><subject>Fetal Blood - metabolism</subject><subject>gene expression regulation</subject><subject>hemoglobin</subject><subject>Humans</subject><subject>hypertension</subject><subject>Intrauterine environment</subject><subject>keratin</subject><subject>Mass Spectrometry</subject><subject>metabolism</subject><subject>Original Research</subject><subject>Pilot Projects</subject><subject>pre-eclampsia</subject><subject>Pre-Eclampsia - blood</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Prenatal</subject><subject>progeny</subject><subject>protective effect</subject><subject>protein synthesis</subject><subject>proteinuria</subject><subject>Proteomics</subject><subject>risk</subject><subject>screening</subject><subject>spectroscopy</subject><subject>umbilical cord</subject><subject>乳腺癌</subject><subject>先兆</subject><subject>子痫</subject><subject>特异性蛋白质</subject><subject>相关蛋白</subject><subject>等离子</subject><subject>色素上皮衍生因子</subject><subject>超高效液相色谱</subject><issn>1672-0229</issn><issn>2210-3244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqFUk2P0zAQjRCIXRZ-ABcINy4pY8d2YiGttJRPaSVWKnu2Jo6TuqRx1063H78eRy2FvcDJY8-bN288L0leEpgQIOLdYtKuqgkFkk9ATgDko-ScUgJZThl7nJwTUdAMKJVnybMQFgCMM0aeJmeUUSmgZOdJM9PemN72bXoTA93hcjVYnU6dr9ObDsMS08b5mHSDsX1Ir0Jw2uJg6nRjh3n60UQCDPH6YTyHdIq9Nj6drYM2kaqynR12z5MnDXbBvDieF8nt508_pl-z6-9fvk2vrjPNBSUZlpLRRja5aKqqEFUtKgqSM4LUaMMROQNkUFDCC5QFA4GS1UUNKKgQEvOLJDvwho1ZrSu18naJfqccWnV8-hkjozjl8aci_vKAj5mlqbXpB4_dg7KHmd7OVevuFct5UeY8EpADwQb7BvtWLdza93FEtdjt62q_34XNdrutlBnXBAJgbPr22NS7u7UJg1ra-Fldh71x66DGtUFJOSn_D-URzCQpyB8l2rsQvGlOUxBQo13UQkW7qFGHAqmiXWLNq7_HP1X89kcEvD4AGnQKW2-Dup1FBg7RTHmej23fHxAmrvXeGq-CtiZaoLbe6EHVzv5TwJuj6Lnr27tow5MGVjJS0rzMfwGCB-Zs</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Low, Hoi Pang</creator><creator>Tiwari, Ashutosh</creator><creator>Janjanam, Jagadeesh</creator><creator>Qiu, Li</creator><creator>Chang, Chien-I</creator><creator>Strohsnitter, William C.</creator><creator>Norwitz, Errol R.</creator><creator>Tam, Sun W.</creator><creator>Evans, James E.</creator><creator>Green, Karin M.</creator><creator>Paulo, Joao A.</creator><creator>Lambe, Mats</creator><creator>Hsieh, Chung-Cheng</creator><general>Elsevier Ltd</general><general>Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA%Department of Chemistry, Michigan Technological University, Houghton, MI 49931, USA%Department of Obstetrics and Gynecology, Tufts Medical Center, Boston, MA 02111, USA</general><general>Elsevier</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7S9</scope><scope>L.6</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>201312</creationdate><title>Screening Preeclamptic Cord Plasma for Proteins Associated with Decreased Breast Cancer Susceptibility</title><author>Low, Hoi Pang ; Tiwari, Ashutosh ; Janjanam, Jagadeesh ; Qiu, Li ; Chang, Chien-I ; Strohsnitter, William C. ; Norwitz, Errol R. ; Tam, Sun W. ; Evans, James E. ; Green, Karin M. ; Paulo, Joao A. ; Lambe, Mats ; Hsieh, Chung-Cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5621-a8942f9f36fbb76bd6b209541a2ece5aa540a4072157a97406a94d7d0a62669a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>adults</topic><topic>analysis</topic><topic>Biomarkers</topic><topic>blood</topic><topic>blood plasma</topic><topic>Blood Proteins</topic><topic>Blood Proteins - analysis</topic><topic>breast neoplasms</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - chemistry</topic><topic>chemistry</topic><topic>Chromatography, Liquid</topic><topic>complement</topic><topic>cytoskeleton</topic><topic>Disease Susceptibility</topic><topic>energy</topic><topic>Female</topic><topic>Fetal Blood</topic><topic>Fetal Blood - chemistry</topic><topic>Fetal Blood - metabolism</topic><topic>gene expression regulation</topic><topic>hemoglobin</topic><topic>Humans</topic><topic>hypertension</topic><topic>Intrauterine environment</topic><topic>keratin</topic><topic>Mass Spectrometry</topic><topic>metabolism</topic><topic>Original Research</topic><topic>Pilot Projects</topic><topic>pre-eclampsia</topic><topic>Pre-Eclampsia - blood</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Prenatal</topic><topic>progeny</topic><topic>protective effect</topic><topic>protein synthesis</topic><topic>proteinuria</topic><topic>Proteomics</topic><topic>risk</topic><topic>screening</topic><topic>spectroscopy</topic><topic>umbilical cord</topic><topic>乳腺癌</topic><topic>先兆</topic><topic>子痫</topic><topic>特异性蛋白质</topic><topic>相关蛋白</topic><topic>等离子</topic><topic>色素上皮衍生因子</topic><topic>超高效液相色谱</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Low, Hoi Pang</creatorcontrib><creatorcontrib>Tiwari, Ashutosh</creatorcontrib><creatorcontrib>Janjanam, Jagadeesh</creatorcontrib><creatorcontrib>Qiu, Li</creatorcontrib><creatorcontrib>Chang, Chien-I</creatorcontrib><creatorcontrib>Strohsnitter, William C.</creatorcontrib><creatorcontrib>Norwitz, Errol R.</creatorcontrib><creatorcontrib>Tam, Sun W.</creatorcontrib><creatorcontrib>Evans, James E.</creatorcontrib><creatorcontrib>Green, Karin M.</creatorcontrib><creatorcontrib>Paulo, Joao A.</creatorcontrib><creatorcontrib>Lambe, Mats</creatorcontrib><creatorcontrib>Hsieh, Chung-Cheng</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - 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As this pro- tective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic profiles of umbilical cord blood plasma between preeclamptic and normotensive pregnancies were compared. Umbilical cord plasma samples, depleted of 14 abundant proteins, were subjected to proteomic analysis using the quantitative method of nanoACQUITY ultra performance liquid chromatography-mass spectrometry with elevated energy mode of acquisitionE （NanoUPLC-MSE）. Sixty-nine differentially expressed proteins were identified, of which 15 and 6 proteins were only detected in preeclamptic and normotensive pregnancies, respectively.Additionally, expression of 8 proteins （gelsolin, complement C5, keratin type I cytoskeletal 10, pigment epithelium-derived factor, complement factor B, complement component C7, hemoglobin subunit gamma-2 and alpha-fetoprotein） were up-regulated in preeclampsia with a fold change of 1〉 2.0 when compared to normotensive pregnancies. The identification of alpha-fetoprotein in pre- eclamptic umbilical cord blood plasma supported the validity of this screen as alpha-fetoprotein has anti-estrogenic properties and has previously been linked to preeclampsia as well as a reduced breast cancer risk. The findings of this pilot study may provide new insights into the mechanistic link between preeclampsia and potentially reduced breast cancer susceptibility in adult life.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24296084</pmid><doi>10.1016/j.gpb.2013.09.009</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1672-0229 |
| ispartof | GENOMICS PROTEOMICS & BIOINFORMATICS, 2013-12, Vol.11 (6), p.335-344 |
| issn | 1672-0229 2210-3244 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_525221 |
| source | Oxford Journals Open Access Collection; MEDLINE; PMC (PubMed Central); Elsevier ScienceDirect Journals; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | adults analysis Biomarkers blood blood plasma Blood Proteins Blood Proteins - analysis breast neoplasms Breast Neoplasms - blood Breast Neoplasms - chemistry chemistry Chromatography, Liquid complement cytoskeleton Disease Susceptibility energy Female Fetal Blood Fetal Blood - chemistry Fetal Blood - metabolism gene expression regulation hemoglobin Humans hypertension Intrauterine environment keratin Mass Spectrometry metabolism Original Research Pilot Projects pre-eclampsia Pre-Eclampsia - blood Preeclampsia Pregnancy Prenatal progeny protective effect protein synthesis proteinuria Proteomics risk screening spectroscopy umbilical cord 乳腺癌 先兆 子痫 特异性蛋白质 相关蛋白 等离子 色素上皮衍生因子 超高效液相色谱 |
| title | Screening Preeclamptic Cord Plasma for Proteins Associated with Decreased Breast Cancer Susceptibility |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T05%3A05%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Screening%20Preeclamptic%20Cord%20Plasma%20for%20Proteins%20Associated%20with%20Decreased%20Breast%20Cancer%20Susceptibility&rft.jtitle=GENOMICS%20PROTEOMICS%20&%20BIOINFORMATICS&rft.au=Low,%20Hoi%20Pang&rft.date=2013-12&rft.volume=11&rft.issue=6&rft.spage=335&rft.epage=344&rft.pages=335-344&rft.issn=1672-0229&rft.eissn=2210-3244&rft_id=info:doi/10.1016/j.gpb.2013.09.009&rft_dat=%3Cwanfang_jour_swepu%3Ejyzdbzzyswxxxb_e201306001%3C/wanfang_jour_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1516749171&rft_id=info:pmid/24296084&rft_cqvip_id=48418238&rft_wanfj_id=jyzdbzzyswxxxb_e201306001&rft_els_id=S1672022913001198&rfr_iscdi=true |