The influence of polygenic risk scores on heritability of anti-CCP level in RA

The objective of this study was to study genetic factors that influence quantitative anticyclic citrullinated peptide (anti-CCP) antibody levels in RA patients. We carried out a genome-wide association study (GWAS) meta-analysis using 1975 anti-CCP+ RA patients from three large cohorts, the Brigham...

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Veröffentlicht in:	Genes and immunity 2014-03, Vol.15 (2), p.107-114
Hauptverfasser:	Cui, J, Taylor, K E, Lee, Y C, Källberg, H, Weinblatt, M E, Coblyn, J S, Klareskog, L, Criswell, L A, Gregersen, P K, Shadick, N A, Plenge, R M, Karlson, E W
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/248 692/699/1670/498 Alleles Antibodies Antigens Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Autoantibodies - immunology Biological markers Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Citrulline Cohort Studies Consortia Diagnosis Drb1 protein Epidemiology Female Gene Expression Genes Genetic diversity Genetic factors Genetic Predisposition to Disease Genetics Genome-wide association studies Genome-Wide Association Study Genomes GPI-Linked Proteins - genetics Health risk assessment Heritability Histocompatibility antigen HLA HLA-DR3 Antigen - genetics HLA-DR3 Antigen - immunology HLA-DRB1 Chains - genetics HLA-DRB1 Chains - immunology Hospitals Human Genetics Humans Immunology Leukocytes Linkage Disequilibrium Male Medical research Meta-analysis Middle Aged Models, Genetic original-article Peptides Peptides, Cyclic - immunology Physiological aspects Polygenic inheritance Polymorphism, Single Nucleotide Prospective Studies Rheumatoid arthritis Rheumatology Single-nucleotide polymorphism Viral antibodies
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