Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis

OBJECTIVE:We investigated potential interactions between human leukocyte antigen (HLA) genotype and body mass index (BMI) status in relation to the risk of developing multiple sclerosis (MS). METHODS:We used 2 case-control studies, one with incident cases (1,510 cases, 2,017 controls) and one with p...

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Veröffentlicht in:	Neurology 2014-03, Vol.82 (10), p.865-872
Hauptverfasser:	Hedström, Anna Karin, Lima Bomfim, Izaura, Barcellos, Lisa, Gianfrancesco, Milena, Schaefer, Catherine, Kockum, Ingrid, Olsson, Tomas, Alfredsson, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Body Mass Index Case-Control Studies Female Genetic Predisposition to Disease Genotype HLA-A2 Antigen - genetics HLA-DRB1 Chains - genetics Humans Immunomodulators Male Medical sciences Metabolic diseases Middle Aged Multiple Sclerosis - epidemiology Multiple Sclerosis - etiology Multiple Sclerosis - genetics Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Obesity Pediatric Obesity - epidemiology Pediatric Obesity - genetics Pharmacology. Drug treatments Risk Factors Young Adult
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