Sex Differences in Outcome and Associations with Neonatal Brain Morphology in Extremely Preterm Children
Objective To investigate sex differences in neurologic and developmental outcomes in extremely preterm (EPT) children and explore associations with neonatal brain morphology. Study design A population-based cohort of infants born at
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| Veröffentlicht in: | The Journal of pediatrics 2014-05, Vol.164 (5), p.1012-1018 |
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| container_title | The Journal of pediatrics |
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| creator | Skiöld, Béatrice, MD, PhD Alexandrou, Georgios, MD, PhD Padilla, Nelly, MD, PhD Blennow, Mats, MD, PhD Vollmer, Brigitte, MD, PhD Ådén, Ulrika, MD, PhD |
| description | Objective To investigate sex differences in neurologic and developmental outcomes in extremely preterm (EPT) children and explore associations with neonatal brain morphology. Study design A population-based cohort of infants born at |
| doi_str_mv | 10.1016/j.jpeds.2013.12.051 |
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| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_523595</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022347613015977</els_id><sourcerecordid>1517881240</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-252e58d79dc6f2f4f9a73290d3881f357eb5dc04ecd00d59d2db6be1fd2ddfcd3</originalsourceid><addsrcrecordid>eNqFks1u1DAUhS0EokPhCZCQl2yS-idOJguQylBapJYiFdaWY18zTpM42AntvD1OZ-iCTVe-sr5zjnTPRegtJTkltDxp83YEE3NGKM8py4mgz9CKkrrKyjXnz9GKEMYyXlTlEXoVY0sIqQtCXqIjVghOKGMrtL2Be_zZWQsBBg0RuwFfz5P2PWA1GHwao9dOTc4PEd-5aYu_gR_UpDr8KagEX_kwbn3nf-0W6dn9FKCHboe_B5gg9HizdZ1J3q_RC6u6CG8O7zH6-eXsx-Yiu7w-_7o5vcx0IdiUMcFArE1VG11aZgtbq4qzmhi-XlPLRQWNMJoUoA0hRtSGmaZsgNo0GKsNP0bZ3jfewTg3cgyuV2EnvXLy8HWbJpCCcVGLxL_f82Pwv2eIk-xd1NB1agA_R0kFrVI0K0hC-R7VwccYwD6aUyKXSmQrHyqRSyWSMpkqSap3h4C56cE8av51kIAPewDSWv44CDJqt5RhXAA9SePdEwEf_9Przg1Oq-4WdhBbP4chbVxSGZNA3ixXsRwFTfGirir-FwZVtOs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1517881240</pqid></control><display><type>article</type><title>Sex Differences in Outcome and Associations with Neonatal Brain Morphology in Extremely Preterm Children</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Skiöld, Béatrice, MD, PhD ; Alexandrou, Georgios, MD, PhD ; Padilla, Nelly, MD, PhD ; Blennow, Mats, MD, PhD ; Vollmer, Brigitte, MD, PhD ; Ådén, Ulrika, MD, PhD</creator><creatorcontrib>Skiöld, Béatrice, MD, PhD ; Alexandrou, Georgios, MD, PhD ; Padilla, Nelly, MD, PhD ; Blennow, Mats, MD, PhD ; Vollmer, Brigitte, MD, PhD ; Ådén, Ulrika, MD, PhD</creatorcontrib><description>Objective To investigate sex differences in neurologic and developmental outcomes in extremely preterm (EPT) children and explore associations with neonatal brain morphology. Study design A population-based cohort of infants born at <27 weeks gestation underwent magnetic resonance imaging (MRI) at term equivalent age (n = 107). Voxel-based morphometry (n = 27) and tract-based spatial statistics (n = 29) were performed in infants with normal MRI findings. Neurologic and developmental assessment (using the Bayley Scales of Infant and Toddler Development–Third Edition [BSITD-III]) was performed at 30 months corrected age (n = 91). Results EPT boys had lower mean cognitive composite scores ( P = .03) and lower mean language composite scores ( P = .04) compared with EPT girls. Rates of cerebral palsy were similar in the 2 sexes. No perinatal factor explained the variance in outcomes. Visual inspection of T1- and T2-weighted MRI images found that delayed myelination was found more frequently in boys, whereas cerebellar abnormalities were more common in girls. In the subgroup of children with normal MRI findings (n = 27), boys had poorer cognitive function ( P = .015) and language function ( P = .008), despite larger volumes of cerebellar tissue ( P = .029). In boys, cerebellar volume was positively correlated with BSITD-III cognitive and motor scores ( P = .04 for both). In girls, white matter volume ( P = .02) and cortical gray matter volume ( P = .03) were positively correlated with BSITD-III language score. At the regional level, significant correlations with outcomes were found only in girls. Conclusion Cognitive and language outcomes at age 30 months were poorer in boys. Sex-related differences were observed on neonatal structural MRI, including differences in the patterns of correlations between brain volumes and developmental scores at both global and regional levels.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2013.12.051</identifier><identifier>PMID: 24530122</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Brain - pathology ; Cerebral Palsy - diagnosis ; Cerebral Palsy - etiology ; Cerebral Palsy - pathology ; Child, Preschool ; Cognition Disorders - diagnosis ; Cognition Disorders - etiology ; Cognition Disorders - pathology ; Developmental Disabilities - diagnosis ; Developmental Disabilities - etiology ; Developmental Disabilities - pathology ; Female ; Follow-Up Studies ; Humans ; Infant, Extremely Premature ; Infant, Newborn ; Infant, Premature, Diseases - diagnosis ; Infant, Premature, Diseases - etiology ; Infant, Premature, Diseases - pathology ; Language Development Disorders - diagnosis ; Language Development Disorders - etiology ; Language Development Disorders - pathology ; Linear Models ; Magnetic Resonance Imaging ; Male ; Multivariate Analysis ; Neuropsychological Tests ; Pediatrics ; Prospective Studies ; Risk Factors ; Sex Factors</subject><ispartof>The Journal of pediatrics, 2014-05, Vol.164 (5), p.1012-1018</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-252e58d79dc6f2f4f9a73290d3881f357eb5dc04ecd00d59d2db6be1fd2ddfcd3</citedby><cites>FETCH-LOGICAL-c452t-252e58d79dc6f2f4f9a73290d3881f357eb5dc04ecd00d59d2db6be1fd2ddfcd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2013.12.051$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24530122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:129057372$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Skiöld, Béatrice, MD, PhD</creatorcontrib><creatorcontrib>Alexandrou, Georgios, MD, PhD</creatorcontrib><creatorcontrib>Padilla, Nelly, MD, PhD</creatorcontrib><creatorcontrib>Blennow, Mats, MD, PhD</creatorcontrib><creatorcontrib>Vollmer, Brigitte, MD, PhD</creatorcontrib><creatorcontrib>Ådén, Ulrika, MD, PhD</creatorcontrib><title>Sex Differences in Outcome and Associations with Neonatal Brain Morphology in Extremely Preterm Children</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Objective To investigate sex differences in neurologic and developmental outcomes in extremely preterm (EPT) children and explore associations with neonatal brain morphology. Study design A population-based cohort of infants born at <27 weeks gestation underwent magnetic resonance imaging (MRI) at term equivalent age (n = 107). Voxel-based morphometry (n = 27) and tract-based spatial statistics (n = 29) were performed in infants with normal MRI findings. Neurologic and developmental assessment (using the Bayley Scales of Infant and Toddler Development–Third Edition [BSITD-III]) was performed at 30 months corrected age (n = 91). Results EPT boys had lower mean cognitive composite scores ( P = .03) and lower mean language composite scores ( P = .04) compared with EPT girls. Rates of cerebral palsy were similar in the 2 sexes. No perinatal factor explained the variance in outcomes. Visual inspection of T1- and T2-weighted MRI images found that delayed myelination was found more frequently in boys, whereas cerebellar abnormalities were more common in girls. In the subgroup of children with normal MRI findings (n = 27), boys had poorer cognitive function ( P = .015) and language function ( P = .008), despite larger volumes of cerebellar tissue ( P = .029). In boys, cerebellar volume was positively correlated with BSITD-III cognitive and motor scores ( P = .04 for both). In girls, white matter volume ( P = .02) and cortical gray matter volume ( P = .03) were positively correlated with BSITD-III language score. At the regional level, significant correlations with outcomes were found only in girls. Conclusion Cognitive and language outcomes at age 30 months were poorer in boys. Sex-related differences were observed on neonatal structural MRI, including differences in the patterns of correlations between brain volumes and developmental scores at both global and regional levels.</description><subject>Brain - pathology</subject><subject>Cerebral Palsy - diagnosis</subject><subject>Cerebral Palsy - etiology</subject><subject>Cerebral Palsy - pathology</subject><subject>Child, Preschool</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - pathology</subject><subject>Developmental Disabilities - diagnosis</subject><subject>Developmental Disabilities - etiology</subject><subject>Developmental Disabilities - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant, Extremely Premature</subject><subject>Infant, Newborn</subject><subject>Infant, Premature, Diseases - diagnosis</subject><subject>Infant, Premature, Diseases - etiology</subject><subject>Infant, Premature, Diseases - pathology</subject><subject>Language Development Disorders - diagnosis</subject><subject>Language Development Disorders - etiology</subject><subject>Language Development Disorders - pathology</subject><subject>Linear Models</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Neuropsychological Tests</subject><subject>Pediatrics</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1u1DAUhS0EokPhCZCQl2yS-idOJguQylBapJYiFdaWY18zTpM42AntvD1OZ-iCTVe-sr5zjnTPRegtJTkltDxp83YEE3NGKM8py4mgz9CKkrrKyjXnz9GKEMYyXlTlEXoVY0sIqQtCXqIjVghOKGMrtL2Be_zZWQsBBg0RuwFfz5P2PWA1GHwao9dOTc4PEd-5aYu_gR_UpDr8KagEX_kwbn3nf-0W6dn9FKCHboe_B5gg9HizdZ1J3q_RC6u6CG8O7zH6-eXsx-Yiu7w-_7o5vcx0IdiUMcFArE1VG11aZgtbq4qzmhi-XlPLRQWNMJoUoA0hRtSGmaZsgNo0GKsNP0bZ3jfewTg3cgyuV2EnvXLy8HWbJpCCcVGLxL_f82Pwv2eIk-xd1NB1agA_R0kFrVI0K0hC-R7VwccYwD6aUyKXSmQrHyqRSyWSMpkqSap3h4C56cE8av51kIAPewDSWv44CDJqt5RhXAA9SePdEwEf_9Przg1Oq-4WdhBbP4chbVxSGZNA3ixXsRwFTfGirir-FwZVtOs</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Skiöld, Béatrice, MD, PhD</creator><creator>Alexandrou, Georgios, MD, PhD</creator><creator>Padilla, Nelly, MD, PhD</creator><creator>Blennow, Mats, MD, PhD</creator><creator>Vollmer, Brigitte, MD, PhD</creator><creator>Ådén, Ulrika, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20140501</creationdate><title>Sex Differences in Outcome and Associations with Neonatal Brain Morphology in Extremely Preterm Children</title><author>Skiöld, Béatrice, MD, PhD ; Alexandrou, Georgios, MD, PhD ; Padilla, Nelly, MD, PhD ; Blennow, Mats, MD, PhD ; Vollmer, Brigitte, MD, PhD ; Ådén, Ulrika, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-252e58d79dc6f2f4f9a73290d3881f357eb5dc04ecd00d59d2db6be1fd2ddfcd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Brain - pathology</topic><topic>Cerebral Palsy - diagnosis</topic><topic>Cerebral Palsy - etiology</topic><topic>Cerebral Palsy - pathology</topic><topic>Child, Preschool</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - pathology</topic><topic>Developmental Disabilities - diagnosis</topic><topic>Developmental Disabilities - etiology</topic><topic>Developmental Disabilities - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant, Extremely Premature</topic><topic>Infant, Newborn</topic><topic>Infant, Premature, Diseases - diagnosis</topic><topic>Infant, Premature, Diseases - etiology</topic><topic>Infant, Premature, Diseases - pathology</topic><topic>Language Development Disorders - diagnosis</topic><topic>Language Development Disorders - etiology</topic><topic>Language Development Disorders - pathology</topic><topic>Linear Models</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Neuropsychological Tests</topic><topic>Pediatrics</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Skiöld, Béatrice, MD, PhD</creatorcontrib><creatorcontrib>Alexandrou, Georgios, MD, PhD</creatorcontrib><creatorcontrib>Padilla, Nelly, MD, PhD</creatorcontrib><creatorcontrib>Blennow, Mats, MD, PhD</creatorcontrib><creatorcontrib>Vollmer, Brigitte, MD, PhD</creatorcontrib><creatorcontrib>Ådén, Ulrika, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skiöld, Béatrice, MD, PhD</au><au>Alexandrou, Georgios, MD, PhD</au><au>Padilla, Nelly, MD, PhD</au><au>Blennow, Mats, MD, PhD</au><au>Vollmer, Brigitte, MD, PhD</au><au>Ådén, Ulrika, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex Differences in Outcome and Associations with Neonatal Brain Morphology in Extremely Preterm Children</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>164</volume><issue>5</issue><spage>1012</spage><epage>1018</epage><pages>1012-1018</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>Objective To investigate sex differences in neurologic and developmental outcomes in extremely preterm (EPT) children and explore associations with neonatal brain morphology. Study design A population-based cohort of infants born at <27 weeks gestation underwent magnetic resonance imaging (MRI) at term equivalent age (n = 107). Voxel-based morphometry (n = 27) and tract-based spatial statistics (n = 29) were performed in infants with normal MRI findings. Neurologic and developmental assessment (using the Bayley Scales of Infant and Toddler Development–Third Edition [BSITD-III]) was performed at 30 months corrected age (n = 91). Results EPT boys had lower mean cognitive composite scores ( P = .03) and lower mean language composite scores ( P = .04) compared with EPT girls. Rates of cerebral palsy were similar in the 2 sexes. No perinatal factor explained the variance in outcomes. Visual inspection of T1- and T2-weighted MRI images found that delayed myelination was found more frequently in boys, whereas cerebellar abnormalities were more common in girls. In the subgroup of children with normal MRI findings (n = 27), boys had poorer cognitive function ( P = .015) and language function ( P = .008), despite larger volumes of cerebellar tissue ( P = .029). In boys, cerebellar volume was positively correlated with BSITD-III cognitive and motor scores ( P = .04 for both). In girls, white matter volume ( P = .02) and cortical gray matter volume ( P = .03) were positively correlated with BSITD-III language score. At the regional level, significant correlations with outcomes were found only in girls. Conclusion Cognitive and language outcomes at age 30 months were poorer in boys. Sex-related differences were observed on neonatal structural MRI, including differences in the patterns of correlations between brain volumes and developmental scores at both global and regional levels.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24530122</pmid><doi>10.1016/j.jpeds.2013.12.051</doi><tpages>7</tpages></addata></record> |
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| subjects | Brain - pathology Cerebral Palsy - diagnosis Cerebral Palsy - etiology Cerebral Palsy - pathology Child, Preschool Cognition Disorders - diagnosis Cognition Disorders - etiology Cognition Disorders - pathology Developmental Disabilities - diagnosis Developmental Disabilities - etiology Developmental Disabilities - pathology Female Follow-Up Studies Humans Infant, Extremely Premature Infant, Newborn Infant, Premature, Diseases - diagnosis Infant, Premature, Diseases - etiology Infant, Premature, Diseases - pathology Language Development Disorders - diagnosis Language Development Disorders - etiology Language Development Disorders - pathology Linear Models Magnetic Resonance Imaging Male Multivariate Analysis Neuropsychological Tests Pediatrics Prospective Studies Risk Factors Sex Factors |
| title | Sex Differences in Outcome and Associations with Neonatal Brain Morphology in Extremely Preterm Children |
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