FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
Background: Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying ge...
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| Veröffentlicht in: | British journal of cancer 2014-02, Vol.110 (4), p.1088-1100 |
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| creator | Agarwal, D Herranz, J Moreno, L T Alonso, M R Wang, Q Bolla, M K Meyer, K B Hardisson, D Mendiola, M Swerdlow, A Orr, N Jones, M Matsuo, K Ito, H Iwata, H Hui, M Sawyer, E Miller, N Choi, J-Y Noh, D-Y Schmidt, D F Makalic, E Southey, M C Teo, S H Yip, C H Sivanandan, K Brauch, H Brüning, T Hamann, U Shah, M Andrulis, I L Knight, J A Tchatchou, S Broeks, A Rosenberg, E H van't Veer, L J Fasching, P A Beckmann, M W Cai, Q Tseng, C-C Cox, A Muir, K Lophatananon, A Siriwanarangsan, P Zheng, W Deming-Halverson, S Shrubsole, M J Long, J Shu, X-O Lu, W Gao, Y-T Zhang, B Manoukian, S Mariette, F Sangrajrang, S McKay, J Couch, F J Yannoukakos, D Johnson, N Marme, F Burwinkel, B Guénel, P Bojesen, S E Nordestgaard, B G Arndt, V Stegmaier, C Mannermaa, A Kataja, V Lambrechts, D Yesilyurt, B T Rudolph, A Seibold, P Wang, X Olson, J E Purrington, K Giles, G G Baglietto, L Haiman, C A Schumacher, F Le Marchand, L Labrèche, F Jukkola-Vuorinen, A Devilee, P García-Closas, M Lissowska, J Czene, K Hooning, M J Kriege, M Li, J Durda, K Nevanlinna, H Muranen, T A Aittomäki, K Bogdanova, N Dörk, T Hall, P Chenevix-Trench, G Easton, D F Pharoah, P D P Arias-Perez, J I |
| description | Background:
Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified
FGFR2
as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in
FGFR1, FGFR3, FGFR4
and
FGFRL1
in the Breast Cancer Association Consortium.
Methods:
Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.
Results:
Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in
FGFR3
; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02–1.09,
P=
0.0020), which is substantially lower than that observed for SNPs in
FGFR2.
Conclusion:
Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for
FGFR2
. |
| doi_str_mv | 10.1038/bjc.2013.769 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_523539</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3222647911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c532t-f3333511426434a70415f1be7d3b48756fa93c11f37be838c6e107b2791be5373</originalsourceid><addsrcrecordid>eNptkk1v1DAQhi0EokvhxhlZ4sKBLP5IYptDpbJiC1IlLnC2HO8k9ZLYi50U9d_jNEu1Rfjij3neGc_oReg1JWtKuPzQ7O2aEcrXolZP0IpWnBVUMvEUrQghoiCKkTP0IqV9vioixXN0xsqqlFKWK7TfXm1xBAuHMUTcgYeEjd_hJoJJI7bGW4g4TWkmXON6N959zII09WPCbQwDHm8Af1rwzYJfphSsM6MLHm-CTyGObhpeomet6RO8Ou7n6Mf28_fNl-L629XXzeV1YfPXx6LleVWUlqwueWkEKWnV0gbEjjelFFXdGsUtpS0XDUgubQ2UiIYJlaGKC36OiiVv-g2HqdGH6AYT73QwTh-ffuYT6IrxiqvMXyx8jgyws-DHaPpHsscR7250F241V0zJei7IlwS9gw50iI3Tt-xeeH-e-k4bqxvQjNVSU0kIq7Lq3bFsDL8mSKMeXJ5y3xsPYUqaVoTUUio5F3j7D7oPU_R5iJqWSknGuKCZer9QNoaUIrQPLVCiZ6vobBU9W0Vnq2T8zWnbD_Bfb5zMMYd8B_Gk6v8S_gGiEcla</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1499822371</pqid></control><display><type>article</type><title>FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SWEPUB Freely available online</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><source>PubMed Central</source><creator>Agarwal, D ; Herranz, J ; Moreno, L T ; Alonso, M R ; Wang, Q ; Bolla, M K ; Meyer, K B ; Hardisson, D ; Mendiola, M ; Swerdlow, A ; Orr, N ; Jones, M ; Matsuo, K ; Ito, H ; Iwata, H ; Hui, M ; Sawyer, E ; Miller, N ; Choi, J-Y ; Noh, D-Y ; Schmidt, D F ; Makalic, E ; Southey, M C ; Teo, S H ; Yip, C H ; Sivanandan, K ; Brauch, H ; Brüning, T ; Hamann, U ; Shah, M ; Andrulis, I L ; Knight, J A ; Tchatchou, S ; Broeks, A ; Rosenberg, E H ; van't Veer, L J ; Fasching, P A ; Beckmann, M W ; Cai, Q ; Tseng, C-C ; Cox, A ; Muir, K ; Lophatananon, A ; Siriwanarangsan, P ; Zheng, W ; Deming-Halverson, S ; Shrubsole, M J ; Long, J ; Shu, X-O ; Lu, W ; Gao, Y-T ; Zhang, B ; Manoukian, S ; Mariette, F ; Sangrajrang, S ; McKay, J ; Couch, F J ; Yannoukakos, D ; Johnson, N ; Marme, F ; Burwinkel, B ; Guénel, P ; Bojesen, S E ; Nordestgaard, B G ; Arndt, V ; Stegmaier, C ; Mannermaa, A ; Kataja, V ; Lambrechts, D ; Yesilyurt, B T ; Rudolph, A ; Seibold, P ; Wang, X ; Olson, J E ; Purrington, K ; Giles, G G ; Baglietto, L ; Haiman, C A ; Schumacher, F ; Le Marchand, L ; Labrèche, F ; Jukkola-Vuorinen, A ; Devilee, P ; García-Closas, M ; Lissowska, J ; Czene, K ; Hooning, M J ; Kriege, M ; Li, J ; Durda, K ; Nevanlinna, H ; Muranen, T A ; Aittomäki, K ; Bogdanova, N ; Dörk, T ; Hall, P ; Chenevix-Trench, G ; Easton, D F ; Pharoah, P D P ; Arias-Perez, J I</creator><creatorcontrib>Agarwal, D ; Herranz, J ; Moreno, L T ; Alonso, M R ; Wang, Q ; Bolla, M K ; Meyer, K B ; Hardisson, D ; Mendiola, M ; Swerdlow, A ; Orr, N ; Jones, M ; Matsuo, K ; Ito, H ; Iwata, H ; Hui, M ; Sawyer, E ; Miller, N ; Choi, J-Y ; Noh, D-Y ; Schmidt, D F ; Makalic, E ; Southey, M C ; Teo, S H ; Yip, C H ; Sivanandan, K ; Brauch, H ; Brüning, T ; Hamann, U ; Shah, M ; Andrulis, I L ; Knight, J A ; Tchatchou, S ; Broeks, A ; Rosenberg, E H ; van't Veer, L J ; Fasching, P A ; Beckmann, M W ; Cai, Q ; Tseng, C-C ; Cox, A ; Muir, K ; Lophatananon, A ; Siriwanarangsan, P ; Zheng, W ; Deming-Halverson, S ; Shrubsole, M J ; Long, J ; Shu, X-O ; Lu, W ; Gao, Y-T ; Zhang, B ; Manoukian, S ; Mariette, F ; Sangrajrang, S ; McKay, J ; Couch, F J ; Yannoukakos, D ; Johnson, N ; Marme, F ; Burwinkel, B ; Guénel, P ; Bojesen, S E ; Nordestgaard, B G ; Arndt, V ; Stegmaier, C ; Mannermaa, A ; Kataja, V ; Lambrechts, D ; Yesilyurt, B T ; Rudolph, A ; Seibold, P ; Wang, X ; Olson, J E ; Purrington, K ; Giles, G G ; Baglietto, L ; Haiman, C A ; Schumacher, F ; Le Marchand, L ; Labrèche, F ; Jukkola-Vuorinen, A ; Devilee, P ; García-Closas, M ; Lissowska, J ; Czene, K ; Hooning, M J ; Kriege, M ; Li, J ; Durda, K ; Nevanlinna, H ; Muranen, T A ; Aittomäki, K ; Bogdanova, N ; Dörk, T ; Hall, P ; Chenevix-Trench, G ; Easton, D F ; Pharoah, P D P ; Arias-Perez, J I ; Australian Ovarian Cancer Study Group ; kConFab Investigators ; TNBCC ; GENICA Network ; The GENICA Network</creatorcontrib><description>Background:
Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified
FGFR2
as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in
FGFR1, FGFR3, FGFR4
and
FGFRL1
in the Breast Cancer Association Consortium.
Methods:
Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.
Results:
Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in
FGFR3
; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02–1.09,
P=
0.0020), which is substantially lower than that observed for SNPs in
FGFR2.
Conclusion:
Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for
FGFR2
.</description><identifier>ISSN: 0007-0920</identifier><identifier>ISSN: 1532-1827</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2013.769</identifier><identifier>PMID: 24548884</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/208/2489/68 ; 631/208/726/649 ; 692/699/67/1347 ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - genetics ; Cancer Research ; Case-Control Studies ; Drug Resistance ; Epidemiology ; Female ; Genetic Predisposition to Disease ; Genetic Variation ; Genetics & genetic processes ; Genetics and Genomics ; Genome-Wide Association Study ; Genotype ; Génétique & processus génétiques ; Humans ; Life sciences ; Molecular Medicine ; Oncology ; Polymorphism, Single Nucleotide - genetics ; Receptor, Fibroblast Growth Factor, Type 1 - genetics ; Receptor, Fibroblast Growth Factor, Type 2 - genetics ; Receptor, Fibroblast Growth Factor, Type 3 - genetics ; Receptor, Fibroblast Growth Factor, Type 4 - genetics ; Receptor, Fibroblast Growth Factor, Type 5 - genetics ; Sciences du vivant</subject><ispartof>British journal of cancer, 2014-02, Vol.110 (4), p.1088-1100</ispartof><rights>The Author(s) 2014</rights><rights>Copyright Nature Publishing Group Feb 18, 2014</rights><rights>Copyright © 2014 Cancer Research UK 2014 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-f3333511426434a70415f1be7d3b48756fa93c11f37be838c6e107b2791be5373</citedby><cites>FETCH-LOGICAL-c532t-f3333511426434a70415f1be7d3b48756fa93c11f37be838c6e107b2791be5373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929867/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929867/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,551,724,777,781,882,27905,27906,41469,42538,51300,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24548884$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:128506024$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Agarwal, D</creatorcontrib><creatorcontrib>Herranz, J</creatorcontrib><creatorcontrib>Moreno, L T</creatorcontrib><creatorcontrib>Alonso, M R</creatorcontrib><creatorcontrib>Wang, Q</creatorcontrib><creatorcontrib>Bolla, M K</creatorcontrib><creatorcontrib>Meyer, K B</creatorcontrib><creatorcontrib>Hardisson, D</creatorcontrib><creatorcontrib>Mendiola, M</creatorcontrib><creatorcontrib>Swerdlow, A</creatorcontrib><creatorcontrib>Orr, N</creatorcontrib><creatorcontrib>Jones, M</creatorcontrib><creatorcontrib>Matsuo, K</creatorcontrib><creatorcontrib>Ito, H</creatorcontrib><creatorcontrib>Iwata, H</creatorcontrib><creatorcontrib>Hui, M</creatorcontrib><creatorcontrib>Sawyer, E</creatorcontrib><creatorcontrib>Miller, N</creatorcontrib><creatorcontrib>Choi, J-Y</creatorcontrib><creatorcontrib>Noh, D-Y</creatorcontrib><creatorcontrib>Schmidt, D F</creatorcontrib><creatorcontrib>Makalic, E</creatorcontrib><creatorcontrib>Southey, M C</creatorcontrib><creatorcontrib>Teo, S H</creatorcontrib><creatorcontrib>Yip, C H</creatorcontrib><creatorcontrib>Sivanandan, K</creatorcontrib><creatorcontrib>Brauch, H</creatorcontrib><creatorcontrib>Brüning, T</creatorcontrib><creatorcontrib>Hamann, U</creatorcontrib><creatorcontrib>Shah, M</creatorcontrib><creatorcontrib>Andrulis, I L</creatorcontrib><creatorcontrib>Knight, J A</creatorcontrib><creatorcontrib>Tchatchou, S</creatorcontrib><creatorcontrib>Broeks, A</creatorcontrib><creatorcontrib>Rosenberg, E H</creatorcontrib><creatorcontrib>van't Veer, L J</creatorcontrib><creatorcontrib>Fasching, P A</creatorcontrib><creatorcontrib>Beckmann, M W</creatorcontrib><creatorcontrib>Cai, Q</creatorcontrib><creatorcontrib>Tseng, C-C</creatorcontrib><creatorcontrib>Cox, A</creatorcontrib><creatorcontrib>Muir, K</creatorcontrib><creatorcontrib>Lophatananon, A</creatorcontrib><creatorcontrib>Siriwanarangsan, P</creatorcontrib><creatorcontrib>Zheng, W</creatorcontrib><creatorcontrib>Deming-Halverson, S</creatorcontrib><creatorcontrib>Shrubsole, M J</creatorcontrib><creatorcontrib>Long, J</creatorcontrib><creatorcontrib>Shu, X-O</creatorcontrib><creatorcontrib>Lu, W</creatorcontrib><creatorcontrib>Gao, Y-T</creatorcontrib><creatorcontrib>Zhang, B</creatorcontrib><creatorcontrib>Manoukian, S</creatorcontrib><creatorcontrib>Mariette, F</creatorcontrib><creatorcontrib>Sangrajrang, S</creatorcontrib><creatorcontrib>McKay, J</creatorcontrib><creatorcontrib>Couch, F J</creatorcontrib><creatorcontrib>Yannoukakos, D</creatorcontrib><creatorcontrib>Johnson, N</creatorcontrib><creatorcontrib>Marme, F</creatorcontrib><creatorcontrib>Burwinkel, B</creatorcontrib><creatorcontrib>Guénel, P</creatorcontrib><creatorcontrib>Bojesen, S E</creatorcontrib><creatorcontrib>Nordestgaard, B G</creatorcontrib><creatorcontrib>Arndt, V</creatorcontrib><creatorcontrib>Stegmaier, C</creatorcontrib><creatorcontrib>Mannermaa, A</creatorcontrib><creatorcontrib>Kataja, V</creatorcontrib><creatorcontrib>Lambrechts, D</creatorcontrib><creatorcontrib>Yesilyurt, B T</creatorcontrib><creatorcontrib>Rudolph, A</creatorcontrib><creatorcontrib>Seibold, P</creatorcontrib><creatorcontrib>Wang, X</creatorcontrib><creatorcontrib>Olson, J E</creatorcontrib><creatorcontrib>Purrington, K</creatorcontrib><creatorcontrib>Giles, G G</creatorcontrib><creatorcontrib>Baglietto, L</creatorcontrib><creatorcontrib>Haiman, C A</creatorcontrib><creatorcontrib>Schumacher, F</creatorcontrib><creatorcontrib>Le Marchand, L</creatorcontrib><creatorcontrib>Labrèche, F</creatorcontrib><creatorcontrib>Jukkola-Vuorinen, A</creatorcontrib><creatorcontrib>Devilee, P</creatorcontrib><creatorcontrib>García-Closas, M</creatorcontrib><creatorcontrib>Lissowska, J</creatorcontrib><creatorcontrib>Czene, K</creatorcontrib><creatorcontrib>Hooning, M J</creatorcontrib><creatorcontrib>Kriege, M</creatorcontrib><creatorcontrib>Li, J</creatorcontrib><creatorcontrib>Durda, K</creatorcontrib><creatorcontrib>Nevanlinna, H</creatorcontrib><creatorcontrib>Muranen, T A</creatorcontrib><creatorcontrib>Aittomäki, K</creatorcontrib><creatorcontrib>Bogdanova, N</creatorcontrib><creatorcontrib>Dörk, T</creatorcontrib><creatorcontrib>Hall, P</creatorcontrib><creatorcontrib>Chenevix-Trench, G</creatorcontrib><creatorcontrib>Easton, D F</creatorcontrib><creatorcontrib>Pharoah, P D P</creatorcontrib><creatorcontrib>Arias-Perez, J I</creatorcontrib><creatorcontrib>Australian Ovarian Cancer Study Group</creatorcontrib><creatorcontrib>kConFab Investigators</creatorcontrib><creatorcontrib>TNBCC</creatorcontrib><creatorcontrib>GENICA Network</creatorcontrib><creatorcontrib>The GENICA Network</creatorcontrib><title>FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified
FGFR2
as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in
FGFR1, FGFR3, FGFR4
and
FGFRL1
in the Breast Cancer Association Consortium.
Methods:
Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.
Results:
Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in
FGFR3
; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02–1.09,
P=
0.0020), which is substantially lower than that observed for SNPs in
FGFR2.
Conclusion:
Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for
FGFR2
.</description><subject>631/208/2489/68</subject><subject>631/208/726/649</subject><subject>692/699/67/1347</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Variation</subject><subject>Genetics & genetic processes</subject><subject>Genetics and Genomics</subject><subject>Genome-Wide Association Study</subject><subject>Genotype</subject><subject>Génétique & processus génétiques</subject><subject>Humans</subject><subject>Life sciences</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Receptor, Fibroblast Growth Factor, Type 1 - genetics</subject><subject>Receptor, Fibroblast Growth Factor, Type 2 - genetics</subject><subject>Receptor, Fibroblast Growth Factor, Type 3 - genetics</subject><subject>Receptor, Fibroblast Growth Factor, Type 4 - genetics</subject><subject>Receptor, Fibroblast Growth Factor, Type 5 - genetics</subject><subject>Sciences du 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UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>Q33</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20140218</creationdate><title>FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium</title><author>Agarwal, D ; Herranz, J ; Moreno, L T ; Alonso, M R ; Wang, Q ; Bolla, M K ; Meyer, K B ; Hardisson, D ; Mendiola, M ; Swerdlow, A ; Orr, N ; Jones, M ; Matsuo, K ; Ito, H ; Iwata, H ; Hui, M ; Sawyer, E ; Miller, N ; Choi, J-Y ; Noh, D-Y ; Schmidt, D F ; Makalic, E ; Southey, M C ; Teo, S H ; Yip, C H ; Sivanandan, K ; Brauch, H ; Brüning, T ; Hamann, U ; Shah, M ; Andrulis, I L ; Knight, J A ; Tchatchou, S ; Broeks, A ; Rosenberg, E H ; van't Veer, L J ; Fasching, P A ; Beckmann, M W ; Cai, Q ; Tseng, C-C ; Cox, A ; Muir, K ; Lophatananon, A ; Siriwanarangsan, P ; Zheng, W ; Deming-Halverson, S ; Shrubsole, M J ; Long, J ; Shu, X-O ; Lu, W ; Gao, Y-T ; Zhang, B ; Manoukian, S ; Mariette, F ; Sangrajrang, S ; McKay, J ; Couch, F J ; Yannoukakos, D ; Johnson, N ; Marme, F ; Burwinkel, B ; Guénel, P ; Bojesen, S E ; Nordestgaard, B G ; Arndt, V ; Stegmaier, C ; Mannermaa, A ; Kataja, V ; Lambrechts, D ; Yesilyurt, B T ; Rudolph, A ; Seibold, P ; Wang, X ; Olson, J E ; Purrington, K ; Giles, G G ; Baglietto, L ; Haiman, C A ; Schumacher, F ; Le Marchand, L ; Labrèche, F ; Jukkola-Vuorinen, A ; Devilee, P ; García-Closas, M ; Lissowska, J ; Czene, K ; Hooning, M J ; Kriege, M ; Li, J ; Durda, K ; Nevanlinna, H ; Muranen, T A ; Aittomäki, K ; Bogdanova, N ; Dörk, T ; Hall, P ; Chenevix-Trench, G ; Easton, D F ; Pharoah, P D P ; Arias-Perez, J I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-f3333511426434a70415f1be7d3b48756fa93c11f37be838c6e107b2791be5373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>631/208/2489/68</topic><topic>631/208/726/649</topic><topic>692/699/67/1347</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Variation</topic><topic>Genetics & genetic processes</topic><topic>Genetics and Genomics</topic><topic>Genome-Wide Association Study</topic><topic>Genotype</topic><topic>Génétique & processus génétiques</topic><topic>Humans</topic><topic>Life sciences</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Receptor, Fibroblast Growth Factor, Type 1 - genetics</topic><topic>Receptor, Fibroblast Growth Factor, Type 2 - genetics</topic><topic>Receptor, Fibroblast Growth Factor, Type 3 - genetics</topic><topic>Receptor, Fibroblast Growth Factor, Type 4 - genetics</topic><topic>Receptor, Fibroblast Growth Factor, Type 5 - genetics</topic><topic>Sciences du vivant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agarwal, D</creatorcontrib><creatorcontrib>Herranz, J</creatorcontrib><creatorcontrib>Moreno, L T</creatorcontrib><creatorcontrib>Alonso, M R</creatorcontrib><creatorcontrib>Wang, Q</creatorcontrib><creatorcontrib>Bolla, M K</creatorcontrib><creatorcontrib>Meyer, K B</creatorcontrib><creatorcontrib>Hardisson, D</creatorcontrib><creatorcontrib>Mendiola, M</creatorcontrib><creatorcontrib>Swerdlow, A</creatorcontrib><creatorcontrib>Orr, N</creatorcontrib><creatorcontrib>Jones, M</creatorcontrib><creatorcontrib>Matsuo, K</creatorcontrib><creatorcontrib>Ito, H</creatorcontrib><creatorcontrib>Iwata, H</creatorcontrib><creatorcontrib>Hui, M</creatorcontrib><creatorcontrib>Sawyer, E</creatorcontrib><creatorcontrib>Miller, N</creatorcontrib><creatorcontrib>Choi, J-Y</creatorcontrib><creatorcontrib>Noh, D-Y</creatorcontrib><creatorcontrib>Schmidt, D F</creatorcontrib><creatorcontrib>Makalic, 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(Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni 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Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Université de Liège - Open Repository and Bibliography (ORBI)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agarwal, D</au><au>Herranz, J</au><au>Moreno, L T</au><au>Alonso, M R</au><au>Wang, Q</au><au>Bolla, M K</au><au>Meyer, K B</au><au>Hardisson, D</au><au>Mendiola, M</au><au>Swerdlow, A</au><au>Orr, N</au><au>Jones, M</au><au>Matsuo, K</au><au>Ito, H</au><au>Iwata, H</au><au>Hui, M</au><au>Sawyer, E</au><au>Miller, N</au><au>Choi, J-Y</au><au>Noh, D-Y</au><au>Schmidt, D F</au><au>Makalic, E</au><au>Southey, M C</au><au>Teo, S H</au><au>Yip, C H</au><au>Sivanandan, K</au><au>Brauch, H</au><au>Brüning, T</au><au>Hamann, U</au><au>Shah, M</au><au>Andrulis, I L</au><au>Knight, J A</au><au>Tchatchou, S</au><au>Broeks, A</au><au>Rosenberg, E H</au><au>van't Veer, L J</au><au>Fasching, P A</au><au>Beckmann, M W</au><au>Cai, Q</au><au>Tseng, C-C</au><au>Cox, A</au><au>Muir, K</au><au>Lophatananon, A</au><au>Siriwanarangsan, P</au><au>Zheng, W</au><au>Deming-Halverson, S</au><au>Shrubsole, M J</au><au>Long, J</au><au>Shu, X-O</au><au>Lu, W</au><au>Gao, Y-T</au><au>Zhang, B</au><au>Manoukian, S</au><au>Mariette, F</au><au>Sangrajrang, S</au><au>McKay, J</au><au>Couch, F J</au><au>Yannoukakos, D</au><au>Johnson, N</au><au>Marme, F</au><au>Burwinkel, B</au><au>Guénel, P</au><au>Bojesen, S E</au><au>Nordestgaard, B G</au><au>Arndt, V</au><au>Stegmaier, C</au><au>Mannermaa, A</au><au>Kataja, V</au><au>Lambrechts, D</au><au>Yesilyurt, B T</au><au>Rudolph, A</au><au>Seibold, P</au><au>Wang, X</au><au>Olson, J E</au><au>Purrington, K</au><au>Giles, G G</au><au>Baglietto, L</au><au>Haiman, C A</au><au>Schumacher, F</au><au>Le Marchand, L</au><au>Labrèche, F</au><au>Jukkola-Vuorinen, A</au><au>Devilee, P</au><au>García-Closas, M</au><au>Lissowska, J</au><au>Czene, K</au><au>Hooning, M J</au><au>Kriege, M</au><au>Li, J</au><au>Durda, K</au><au>Nevanlinna, H</au><au>Muranen, T A</au><au>Aittomäki, K</au><au>Bogdanova, N</au><au>Dörk, T</au><au>Hall, P</au><au>Chenevix-Trench, G</au><au>Easton, D F</au><au>Pharoah, P D P</au><au>Arias-Perez, J I</au><aucorp>Australian Ovarian Cancer Study Group</aucorp><aucorp>kConFab Investigators</aucorp><aucorp>TNBCC</aucorp><aucorp>GENICA Network</aucorp><aucorp>The GENICA Network</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2014-02-18</date><risdate>2014</risdate><volume>110</volume><issue>4</issue><spage>1088</spage><epage>1100</epage><pages>1088-1100</pages><issn>0007-0920</issn><issn>1532-1827</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified
FGFR2
as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in
FGFR1, FGFR3, FGFR4
and
FGFRL1
in the Breast Cancer Association Consortium.
Methods:
Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression.
Results:
Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in
FGFR3
; the estimated per-allele odds ratio was 1.05 (95% confidence interval=1.02–1.09,
P=
0.0020), which is substantially lower than that observed for SNPs in
FGFR2.
Conclusion:
Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for
FGFR2
.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24548884</pmid><doi>10.1038/bjc.2013.769</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2014-02, Vol.110 (4), p.1088-1100 |
| issn | 0007-0920 1532-1827 1532-1827 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_523539 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Springer Nature - Complete Springer Journals; Nature Journals Online; PubMed Central |
| subjects | 631/208/2489/68 631/208/726/649 692/699/67/1347 Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Cancer Research Case-Control Studies Drug Resistance Epidemiology Female Genetic Predisposition to Disease Genetic Variation Genetics & genetic processes Genetics and Genomics Genome-Wide Association Study Genotype Génétique & processus génétiques Humans Life sciences Molecular Medicine Oncology Polymorphism, Single Nucleotide - genetics Receptor, Fibroblast Growth Factor, Type 1 - genetics Receptor, Fibroblast Growth Factor, Type 2 - genetics Receptor, Fibroblast Growth Factor, Type 3 - genetics Receptor, Fibroblast Growth Factor, Type 4 - genetics Receptor, Fibroblast Growth Factor, Type 5 - genetics Sciences du vivant |
| title | FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium |
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