Estrogen receptor beta as a novel target of androgen receptor action in breast cancer cell lines

The two isoforms of estrogen receptor (ER) alpha and beta play opposite roles in regulating proliferation and differentiation of breast cancers, with ER-alpha mediating mitogenic effects and ER-beta acting as a tumor suppressor. Emerging data have reported that androgen receptor (AR) activation inhi...

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Veröffentlicht in:	Breast cancer research : BCR 2014-02, Vol.16 (1), p.R21-R21, Article R21
Hauptverfasser:	Rizza, Pietro, Barone, Ines, Zito, Domenico, Giordano, Francesca, Lanzino, Marilena, De Amicis, Francesca, Mauro, Loredana, Sisci, Diego, Catalano, Stefania, Dahlman Wright, Karin, Gustafsson, Jan-Ake, Andò, Sebastiano
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation - genetics Chromatin Cyclin D1 - biosynthesis Enzyme Activation Estrogen Receptor alpha - metabolism Estrogen Receptor beta - biosynthesis Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Female Genes Humans MCF-7 Cells Mutagenesis, Site-Directed Nandrolone - analogs & derivatives Nandrolone - pharmacology Physiological aspects Promoter Regions, Genetic - drug effects Protein Binding Receptors, Androgen - metabolism rho GTP-Binding Proteins - biosynthesis RNA Interference RNA Polymerase II - genetics RNA, Messenger - biosynthesis RNA, Small Interfering Testosterone Congeners - pharmacology Up-Regulation
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