Long‐term prognosis of clinical symptoms and health‐related quality of life in microscopic colitis: a case–control study
Summary Background Microscopic colitis, comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhoea. The long‐term prognosis is not well described. Aim To study outcome of symptoms and health‐related quality of life (HRQoL). Methods A case–control study u...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2014-05, Vol.39 (9), p.963-972 |
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| creator | Nyhlin, N. Wickbom, A. Montgomery, S. M. Tysk, C. Bohr, J. |
| description | Summary
Background
Microscopic colitis, comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhoea. The long‐term prognosis is not well described.
Aim
To study outcome of symptoms and health‐related quality of life (HRQoL).
Methods
A case–control study using a postal questionnaire with three population‐based controls per patient matched for age, sex and municipality. HRQoL was assessed by the Short Health Scale (SHS). Patients in clinical remission, defined as a mean of |
| doi_str_mv | 10.1111/apt.12685 |
| format | Article |
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Background
Microscopic colitis, comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhoea. The long‐term prognosis is not well described.
Aim
To study outcome of symptoms and health‐related quality of life (HRQoL).
Methods
A case–control study using a postal questionnaire with three population‐based controls per patient matched for age, sex and municipality. HRQoL was assessed by the Short Health Scale (SHS). Patients in clinical remission, defined as a mean of <3 stools/day, were evaluated separately (CC; n = 72, LC; n = 60).
Results
The study included 212 patients and 627 matched controls. Median disease duration was 5.9 (range 0.5–27) years and 6.4 (0.3–14.8) years for CC and LC respectively. Abdominal pain, fatigue, arthralgia, myalgia, faecal incontinence and nocturnal defecation were significantly more prevalent in CC patients compared with controls. These differences persisted in CC patients in clinical remission with respect to abdominal pain (36% vs. 21%), fatigue (54% vs. 34%), arthralgia (61% vs. 41%) and myalgia (53% vs. 37%). In LC patients, abdominal pain, fatigue, faecal incontinence and nocturnal defecation were more prevalent compared with controls. In LC patients in clinical remission, fatigue was more prevalent compared with controls (54% vs. 37%). These differences were statistically significant (P < 0.05). All four HRQoL dimensions (symptom burden, social function, disease‐related worry, general well‐being) were impaired in patients with active CC and LC.
Conclusions
Although considered to be in clinical remission, patients with microscopic colitis suffer from persisting symptoms such as abdominal pain, fatigue, arthralgia or myalgia several years after diagnosis.</description><identifier>ISSN: 0269-2813</identifier><identifier>ISSN: 1365-2036</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.12685</identifier><identifier>PMID: 24612051</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Abdominal Pain - epidemiology ; Abdominal Pain - etiology ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Case-Control Studies ; Colitis, Collagenous - physiopathology ; Colitis, Lymphocytic - physiopathology ; Diarrhea - etiology ; Fatigue - epidemiology ; Fatigue - etiology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Prognosis ; Quality of Life ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surveys and Questionnaires ; Time Factors</subject><ispartof>Alimentary pharmacology & therapeutics, 2014-05, Vol.39 (9), p.963-972</ispartof><rights>2014 John Wiley & Sons Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2014 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5315-a2086c730679ddb9b599ddd28f4eafa81429c967e3a76c424232a5cec6f96bb73</citedby><cites>FETCH-LOGICAL-c5315-a2086c730679ddb9b599ddd28f4eafa81429c967e3a76c424232a5cec6f96bb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.12685$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.12685$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27902,27903,45552,45553,46386,46810</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28340475$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24612051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-34938$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:128587012$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Nyhlin, N.</creatorcontrib><creatorcontrib>Wickbom, A.</creatorcontrib><creatorcontrib>Montgomery, S. M.</creatorcontrib><creatorcontrib>Tysk, C.</creatorcontrib><creatorcontrib>Bohr, J.</creatorcontrib><title>Long‐term prognosis of clinical symptoms and health‐related quality of life in microscopic colitis: a case–control study</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
Microscopic colitis, comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhoea. The long‐term prognosis is not well described.
Aim
To study outcome of symptoms and health‐related quality of life (HRQoL).
Methods
A case–control study using a postal questionnaire with three population‐based controls per patient matched for age, sex and municipality. HRQoL was assessed by the Short Health Scale (SHS). Patients in clinical remission, defined as a mean of <3 stools/day, were evaluated separately (CC; n = 72, LC; n = 60).
Results
The study included 212 patients and 627 matched controls. Median disease duration was 5.9 (range 0.5–27) years and 6.4 (0.3–14.8) years for CC and LC respectively. Abdominal pain, fatigue, arthralgia, myalgia, faecal incontinence and nocturnal defecation were significantly more prevalent in CC patients compared with controls. These differences persisted in CC patients in clinical remission with respect to abdominal pain (36% vs. 21%), fatigue (54% vs. 34%), arthralgia (61% vs. 41%) and myalgia (53% vs. 37%). In LC patients, abdominal pain, fatigue, faecal incontinence and nocturnal defecation were more prevalent compared with controls. In LC patients in clinical remission, fatigue was more prevalent compared with controls (54% vs. 37%). These differences were statistically significant (P < 0.05). All four HRQoL dimensions (symptom burden, social function, disease‐related worry, general well‐being) were impaired in patients with active CC and LC.
Conclusions
Although considered to be in clinical remission, patients with microscopic colitis suffer from persisting symptoms such as abdominal pain, fatigue, arthralgia or myalgia several years after diagnosis.</description><subject>Abdominal Pain - epidemiology</subject><subject>Abdominal Pain - etiology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Colitis, Collagenous - physiopathology</subject><subject>Colitis, Lymphocytic - physiopathology</subject><subject>Diarrhea - etiology</subject><subject>Fatigue - epidemiology</subject><subject>Fatigue - etiology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Prognosis</subject><subject>Quality of Life</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surveys and Questionnaires</subject><subject>Time Factors</subject><issn>0269-2813</issn><issn>1365-2036</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhS1ERYfCghdA3iCBRFr_xE7S3aj8VRqpLApb68ZxpgYnTu1EVTaoj4DEG_ZJ8JBpWdWSdS37u-dY9yD0ipJjmtYJDOMxZbIUT9CKcikyRrh8ilaEySpjJeWH6HmMPwghsiDsGTpkuaSMCLpCvza-397d_h5N6PAQ_Lb30UbsW6yd7a0Gh-PcDaPvIoa-wVcG3HiVGoJxMJoGX0_g7DjvOpxtDbY97qwOPmo_WI21T682nmLAGqK5u_2jfT8Gn2THqZlfoIMWXDQv9_UIffv08fLsS7a5-Hx-tt5kWnAqMmCklLrg6f9V09RVLapUG1a2uYEWSpqzSleyMBwKqXOWM85AaKNlW8m6LvgRyhbdeGOGqVZDsB2EWXmwan_1M52MEownq8S_f5T_YL-vlQ_btCfF84qXCX-74GmC15OJo-ps1MY56I2foqKCMiFKUvKEvlvQ3YxiMO2DNiVql6ZKaap_aSb29V52qjvTPJD38SXgzR6AmKJqA_Taxv9cyXOSFzuhk4W7sc7Mjzuq9dfLxfovoue7-A</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Nyhlin, N.</creator><creator>Wickbom, A.</creator><creator>Montgomery, S. M.</creator><creator>Tysk, C.</creator><creator>Bohr, J.</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D91</scope></search><sort><creationdate>201405</creationdate><title>Long‐term prognosis of clinical symptoms and health‐related quality of life in microscopic colitis: a case–control study</title><author>Nyhlin, N. ; Wickbom, A. ; Montgomery, S. M. ; Tysk, C. ; Bohr, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5315-a2086c730679ddb9b599ddd28f4eafa81429c967e3a76c424232a5cec6f96bb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abdominal Pain - epidemiology</topic><topic>Abdominal Pain - etiology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Colitis, Collagenous - physiopathology</topic><topic>Colitis, Lymphocytic - physiopathology</topic><topic>Diarrhea - etiology</topic><topic>Fatigue - epidemiology</topic><topic>Fatigue - etiology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Prognosis</topic><topic>Quality of Life</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surveys and Questionnaires</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nyhlin, N.</creatorcontrib><creatorcontrib>Wickbom, A.</creatorcontrib><creatorcontrib>Montgomery, S. M.</creatorcontrib><creatorcontrib>Tysk, C.</creatorcontrib><creatorcontrib>Bohr, J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Örebro universitet</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nyhlin, N.</au><au>Wickbom, A.</au><au>Montgomery, S. M.</au><au>Tysk, C.</au><au>Bohr, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long‐term prognosis of clinical symptoms and health‐related quality of life in microscopic colitis: a case–control study</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2014-05</date><risdate>2014</risdate><volume>39</volume><issue>9</issue><spage>963</spage><epage>972</epage><pages>963-972</pages><issn>0269-2813</issn><issn>1365-2036</issn><eissn>1365-2036</eissn><abstract>Summary
Background
Microscopic colitis, comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhoea. The long‐term prognosis is not well described.
Aim
To study outcome of symptoms and health‐related quality of life (HRQoL).
Methods
A case–control study using a postal questionnaire with three population‐based controls per patient matched for age, sex and municipality. HRQoL was assessed by the Short Health Scale (SHS). Patients in clinical remission, defined as a mean of <3 stools/day, were evaluated separately (CC; n = 72, LC; n = 60).
Results
The study included 212 patients and 627 matched controls. Median disease duration was 5.9 (range 0.5–27) years and 6.4 (0.3–14.8) years for CC and LC respectively. Abdominal pain, fatigue, arthralgia, myalgia, faecal incontinence and nocturnal defecation were significantly more prevalent in CC patients compared with controls. These differences persisted in CC patients in clinical remission with respect to abdominal pain (36% vs. 21%), fatigue (54% vs. 34%), arthralgia (61% vs. 41%) and myalgia (53% vs. 37%). In LC patients, abdominal pain, fatigue, faecal incontinence and nocturnal defecation were more prevalent compared with controls. In LC patients in clinical remission, fatigue was more prevalent compared with controls (54% vs. 37%). These differences were statistically significant (P < 0.05). All four HRQoL dimensions (symptom burden, social function, disease‐related worry, general well‐being) were impaired in patients with active CC and LC.
Conclusions
Although considered to be in clinical remission, patients with microscopic colitis suffer from persisting symptoms such as abdominal pain, fatigue, arthralgia or myalgia several years after diagnosis.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>24612051</pmid><doi>10.1111/apt.12685</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | Abdominal Pain - epidemiology Abdominal Pain - etiology Adult Aged Aged, 80 and over Biological and medical sciences Case-Control Studies Colitis, Collagenous - physiopathology Colitis, Lymphocytic - physiopathology Diarrhea - etiology Fatigue - epidemiology Fatigue - etiology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Other diseases. Semiology Prognosis Quality of Life Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surveys and Questionnaires Time Factors |
| title | Long‐term prognosis of clinical symptoms and health‐related quality of life in microscopic colitis: a case–control study |
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