Risperidone metabolic ratio as a biomarker of individual CYP2D6 genotype in schizophrenic patients

Purpose The purpose of the present study was to investigate the predictive value of the risperidone metabolic ratio for the individual CYP2D6 genotype. Methods The determination of risperidone, 9-hydroxyrisperidone, and CYP2D6 genotype was performed in 89 schizophrenic patients. The receiver operato...

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Veröffentlicht in:	European journal of clinical pharmacology 2014-06, Vol.70 (6), p.695-699
Hauptverfasser:	Mannheimer, Buster, Holm, Johan, Koukel, Larissa, Bertilsson, Leif, Ösby, Urban, Eliasson, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Aged Antipsychotic Agents - blood Antipsychotic Agents - metabolism Antipsychotic Agents - pharmacokinetics Antipsychotic Agents - therapeutic use Area Under Curve Biological and medical sciences Biomarkers Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Cytochrome P-450 CYP2D6 - genetics Female Gene Frequency Genetics Genotype Genotype & phenotype Humans Male Medical sciences Metabolic Clearance Rate Metabolism Middle Aged Pharmacogenetics Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Polymorphism Predictive Value of Tests Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotropic drugs Risperidone - blood Risperidone - metabolism Risperidone - pharmacokinetics Risperidone - therapeutic use ROC Curve Schizophrenia Schizophrenia - drug therapy Schizophrenia - genetics Schizophrenia - metabolism Sensitivity and Specificity Young Adult
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