Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) substantially challenges TB control, especially in the European Region of the World Health Organization, where the highest prevalence of MDR/XDR cases is reported. The current management of patients wit...
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| Veröffentlicht in: | EUROPEAN RESPIRATORY JOURNAL 2014-07, Vol.44 (1), p.23-63 |
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| creator | LANGE, Christoph ABUBAKAR, Ibrahim DAVIES, Peter DEDICOAT, Martin DROBNIEWSKI, Francis DUARTE, Raquel EHLERS, Cordula ERKENS, Connie GOLETTI, Delia GÜNTHER, Gunar IBRAIM, Elmira KAMPMANN, Beate ALFFENAAR, Jan-Willem C KUKSA, Liga DE LANGE, Wiel VAN LETH, Frank VAN LUNZEN, Jan MATTEELLI, Alberto MENZIES, Dick MONEDERO, Ignacio RICHTER, Elvira RÜSCH-GERDES, Sabine SANDGREN, Andreas BOTHAMLEY, Graham SCARDIGLI, Anna SKRAHINA, Alena TORTOLI, Enrico VOLCHENKOV, Grigory WAGNER, Dirk VAN DER WERF, Marieke J WILLIAMS, Bhanu YEW, Wing-Wai ZELLWEGER, Jean-Pierre CIRILLO, Daniela Maria CAMINERO, Jose A CARVALHO, Anna Cristina C CHANG, Kwok-Chiu CODECASA, Luigi CORREIA, Ana CRUDU, Valeriu |
| description | The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) substantially challenges TB control, especially in the European Region of the World Health Organization, where the highest prevalence of MDR/XDR cases is reported. The current management of patients with MDR/XDR-TB is extremely complex for medical, social and public health systems. The treatment with currently available anti-TB therapies to achieve relapse-free cure is long and undermined by a high frequency of adverse drug events, suboptimal treatment adherence, high costs and low treatment success rates. Availability of optimal management for patients with MDR/XDR-TB is limited even in the European Region. In the absence of a preventive vaccine, more effective diagnostic tools and novel therapeutic interventions the control of MDR/XDR-TB will be extremely difficult. Despite recent scientific advances in MDR/XDR-TB care, decisions for the management of patients with MDR/XDR-TB and their contacts often rely on expert opinions, rather than on clinical evidence. This document summarises the current knowledge on the prevention, diagnosis and treatment of adults and children with MDR/XDR-TB and their contacts, and provides expert consensus recommendations on questions where scientific evidence is still lacking. |
| doi_str_mv | 10.1183/09031936.00188313 |
| format | Article |
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The current management of patients with MDR/XDR-TB is extremely complex for medical, social and public health systems. The treatment with currently available anti-TB therapies to achieve relapse-free cure is long and undermined by a high frequency of adverse drug events, suboptimal treatment adherence, high costs and low treatment success rates. Availability of optimal management for patients with MDR/XDR-TB is limited even in the European Region. In the absence of a preventive vaccine, more effective diagnostic tools and novel therapeutic interventions the control of MDR/XDR-TB will be extremely difficult. Despite recent scientific advances in MDR/XDR-TB care, decisions for the management of patients with MDR/XDR-TB and their contacts often rely on expert opinions, rather than on clinical evidence. This document summarises the current knowledge on the prevention, diagnosis and treatment of adults and children with MDR/XDR-TB and their contacts, and provides expert consensus recommendations on questions where scientific evidence is still lacking.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.00188313</identifier><identifier>PMID: 24659544</identifier><language>eng</language><publisher>Leeds: Maney</publisher><subject>Antitubercular Agents - therapeutic use ; Bacterial diseases ; Biological and medical sciences ; Case Management ; Clinical Trials as Topic ; Communicable Disease Control ; Consensus ; Consensus Statement ; Disease Management ; Disease-Free Survival ; Europe ; Extensively Drug-Resistant Tuberculosis - epidemiology ; Extensively Drug-Resistant Tuberculosis - prevention & control ; Extensively Drug-Resistant Tuberculosis - therapy ; Geography ; Human bacterial diseases ; Humans ; Infectious Disease Medicine - standards ; Infectious diseases ; Medical sciences ; Mycobacterium ; Pneumology ; Public Health ; Recurrence ; Treatment Outcome ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Multidrug-Resistant - epidemiology ; Tuberculosis, Multidrug-Resistant - prevention & control ; Tuberculosis, Multidrug-Resistant - therapy ; World Health Organization</subject><ispartof>EUROPEAN RESPIRATORY JOURNAL, 2014-07, Vol.44 (1), p.23-63</ispartof><rights>2015 INIST-CNRS</rights><rights>ERS 2014.</rights><rights>ERS 2014 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-961cdd5e570f169d548c2caea88849913d45206053e9dd6c3857f4ee1eee3c643</citedby><cites>FETCH-LOGICAL-c430t-961cdd5e570f169d548c2caea88849913d45206053e9dd6c3857f4ee1eee3c643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28535556$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24659544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:129419578$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>LANGE, Christoph</creatorcontrib><creatorcontrib>ABUBAKAR, Ibrahim</creatorcontrib><creatorcontrib>DAVIES, Peter</creatorcontrib><creatorcontrib>DEDICOAT, Martin</creatorcontrib><creatorcontrib>DROBNIEWSKI, Francis</creatorcontrib><creatorcontrib>DUARTE, Raquel</creatorcontrib><creatorcontrib>EHLERS, Cordula</creatorcontrib><creatorcontrib>ERKENS, Connie</creatorcontrib><creatorcontrib>GOLETTI, Delia</creatorcontrib><creatorcontrib>GÜNTHER, Gunar</creatorcontrib><creatorcontrib>IBRAIM, Elmira</creatorcontrib><creatorcontrib>KAMPMANN, Beate</creatorcontrib><creatorcontrib>ALFFENAAR, Jan-Willem C</creatorcontrib><creatorcontrib>KUKSA, Liga</creatorcontrib><creatorcontrib>DE LANGE, Wiel</creatorcontrib><creatorcontrib>VAN LETH, Frank</creatorcontrib><creatorcontrib>VAN LUNZEN, Jan</creatorcontrib><creatorcontrib>MATTEELLI, Alberto</creatorcontrib><creatorcontrib>MENZIES, Dick</creatorcontrib><creatorcontrib>MONEDERO, Ignacio</creatorcontrib><creatorcontrib>RICHTER, Elvira</creatorcontrib><creatorcontrib>RÜSCH-GERDES, Sabine</creatorcontrib><creatorcontrib>SANDGREN, Andreas</creatorcontrib><creatorcontrib>BOTHAMLEY, Graham</creatorcontrib><creatorcontrib>SCARDIGLI, Anna</creatorcontrib><creatorcontrib>SKRAHINA, Alena</creatorcontrib><creatorcontrib>TORTOLI, Enrico</creatorcontrib><creatorcontrib>VOLCHENKOV, Grigory</creatorcontrib><creatorcontrib>WAGNER, Dirk</creatorcontrib><creatorcontrib>VAN DER WERF, Marieke J</creatorcontrib><creatorcontrib>WILLIAMS, Bhanu</creatorcontrib><creatorcontrib>YEW, Wing-Wai</creatorcontrib><creatorcontrib>ZELLWEGER, Jean-Pierre</creatorcontrib><creatorcontrib>CIRILLO, Daniela Maria</creatorcontrib><creatorcontrib>CAMINERO, Jose A</creatorcontrib><creatorcontrib>CARVALHO, Anna Cristina C</creatorcontrib><creatorcontrib>CHANG, Kwok-Chiu</creatorcontrib><creatorcontrib>CODECASA, Luigi</creatorcontrib><creatorcontrib>CORREIA, Ana</creatorcontrib><creatorcontrib>CRUDU, Valeriu</creatorcontrib><creatorcontrib>TBNET</creatorcontrib><title>Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement</title><title>EUROPEAN RESPIRATORY JOURNAL</title><addtitle>Eur Respir J</addtitle><description>The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) substantially challenges TB control, especially in the European Region of the World Health Organization, where the highest prevalence of MDR/XDR cases is reported. The current management of patients with MDR/XDR-TB is extremely complex for medical, social and public health systems. The treatment with currently available anti-TB therapies to achieve relapse-free cure is long and undermined by a high frequency of adverse drug events, suboptimal treatment adherence, high costs and low treatment success rates. Availability of optimal management for patients with MDR/XDR-TB is limited even in the European Region. In the absence of a preventive vaccine, more effective diagnostic tools and novel therapeutic interventions the control of MDR/XDR-TB will be extremely difficult. Despite recent scientific advances in MDR/XDR-TB care, decisions for the management of patients with MDR/XDR-TB and their contacts often rely on expert opinions, rather than on clinical evidence. 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epidemiology</topic><topic>Tuberculosis, Multidrug-Resistant - prevention & control</topic><topic>Tuberculosis, Multidrug-Resistant - therapy</topic><topic>World Health Organization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LANGE, Christoph</creatorcontrib><creatorcontrib>ABUBAKAR, Ibrahim</creatorcontrib><creatorcontrib>DAVIES, Peter</creatorcontrib><creatorcontrib>DEDICOAT, Martin</creatorcontrib><creatorcontrib>DROBNIEWSKI, Francis</creatorcontrib><creatorcontrib>DUARTE, Raquel</creatorcontrib><creatorcontrib>EHLERS, Cordula</creatorcontrib><creatorcontrib>ERKENS, Connie</creatorcontrib><creatorcontrib>GOLETTI, Delia</creatorcontrib><creatorcontrib>GÜNTHER, Gunar</creatorcontrib><creatorcontrib>IBRAIM, Elmira</creatorcontrib><creatorcontrib>KAMPMANN, Beate</creatorcontrib><creatorcontrib>ALFFENAAR, Jan-Willem C</creatorcontrib><creatorcontrib>KUKSA, Liga</creatorcontrib><creatorcontrib>DE LANGE, Wiel</creatorcontrib><creatorcontrib>VAN LETH, Frank</creatorcontrib><creatorcontrib>VAN LUNZEN, Jan</creatorcontrib><creatorcontrib>MATTEELLI, Alberto</creatorcontrib><creatorcontrib>MENZIES, Dick</creatorcontrib><creatorcontrib>MONEDERO, Ignacio</creatorcontrib><creatorcontrib>RICHTER, Elvira</creatorcontrib><creatorcontrib>RÜSCH-GERDES, Sabine</creatorcontrib><creatorcontrib>SANDGREN, Andreas</creatorcontrib><creatorcontrib>BOTHAMLEY, Graham</creatorcontrib><creatorcontrib>SCARDIGLI, Anna</creatorcontrib><creatorcontrib>SKRAHINA, Alena</creatorcontrib><creatorcontrib>TORTOLI, Enrico</creatorcontrib><creatorcontrib>VOLCHENKOV, Grigory</creatorcontrib><creatorcontrib>WAGNER, Dirk</creatorcontrib><creatorcontrib>VAN DER WERF, Marieke J</creatorcontrib><creatorcontrib>WILLIAMS, Bhanu</creatorcontrib><creatorcontrib>YEW, Wing-Wai</creatorcontrib><creatorcontrib>ZELLWEGER, Jean-Pierre</creatorcontrib><creatorcontrib>CIRILLO, Daniela Maria</creatorcontrib><creatorcontrib>CAMINERO, Jose A</creatorcontrib><creatorcontrib>CARVALHO, Anna Cristina C</creatorcontrib><creatorcontrib>CHANG, Kwok-Chiu</creatorcontrib><creatorcontrib>CODECASA, Luigi</creatorcontrib><creatorcontrib>CORREIA, Ana</creatorcontrib><creatorcontrib>CRUDU, Valeriu</creatorcontrib><creatorcontrib>TBNET</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>EUROPEAN RESPIRATORY JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LANGE, Christoph</au><au>ABUBAKAR, Ibrahim</au><au>DAVIES, Peter</au><au>DEDICOAT, Martin</au><au>DROBNIEWSKI, Francis</au><au>DUARTE, Raquel</au><au>EHLERS, Cordula</au><au>ERKENS, Connie</au><au>GOLETTI, Delia</au><au>GÜNTHER, Gunar</au><au>IBRAIM, Elmira</au><au>KAMPMANN, Beate</au><au>ALFFENAAR, Jan-Willem C</au><au>KUKSA, Liga</au><au>DE LANGE, Wiel</au><au>VAN LETH, Frank</au><au>VAN LUNZEN, Jan</au><au>MATTEELLI, Alberto</au><au>MENZIES, Dick</au><au>MONEDERO, Ignacio</au><au>RICHTER, Elvira</au><au>RÜSCH-GERDES, Sabine</au><au>SANDGREN, Andreas</au><au>BOTHAMLEY, Graham</au><au>SCARDIGLI, Anna</au><au>SKRAHINA, Alena</au><au>TORTOLI, Enrico</au><au>VOLCHENKOV, Grigory</au><au>WAGNER, Dirk</au><au>VAN DER WERF, Marieke J</au><au>WILLIAMS, Bhanu</au><au>YEW, Wing-Wai</au><au>ZELLWEGER, Jean-Pierre</au><au>CIRILLO, Daniela Maria</au><au>CAMINERO, Jose A</au><au>CARVALHO, Anna Cristina C</au><au>CHANG, Kwok-Chiu</au><au>CODECASA, Luigi</au><au>CORREIA, Ana</au><au>CRUDU, Valeriu</au><aucorp>TBNET</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement</atitle><jtitle>EUROPEAN RESPIRATORY JOURNAL</jtitle><addtitle>Eur Respir J</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>44</volume><issue>1</issue><spage>23</spage><epage>63</epage><pages>23-63</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) substantially challenges TB control, especially in the European Region of the World Health Organization, where the highest prevalence of MDR/XDR cases is reported. The current management of patients with MDR/XDR-TB is extremely complex for medical, social and public health systems. The treatment with currently available anti-TB therapies to achieve relapse-free cure is long and undermined by a high frequency of adverse drug events, suboptimal treatment adherence, high costs and low treatment success rates. Availability of optimal management for patients with MDR/XDR-TB is limited even in the European Region. In the absence of a preventive vaccine, more effective diagnostic tools and novel therapeutic interventions the control of MDR/XDR-TB will be extremely difficult. Despite recent scientific advances in MDR/XDR-TB care, decisions for the management of patients with MDR/XDR-TB and their contacts often rely on expert opinions, rather than on clinical evidence. This document summarises the current knowledge on the prevention, diagnosis and treatment of adults and children with MDR/XDR-TB and their contacts, and provides expert consensus recommendations on questions where scientific evidence is still lacking.</abstract><cop>Leeds</cop><pub>Maney</pub><pmid>24659544</pmid><doi>10.1183/09031936.00188313</doi><tpages>41</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0903-1936 |
| ispartof | EUROPEAN RESPIRATORY JOURNAL, 2014-07, Vol.44 (1), p.23-63 |
| issn | 0903-1936 1399-3003 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_522769 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online |
| subjects | Antitubercular Agents - therapeutic use Bacterial diseases Biological and medical sciences Case Management Clinical Trials as Topic Communicable Disease Control Consensus Consensus Statement Disease Management Disease-Free Survival Europe Extensively Drug-Resistant Tuberculosis - epidemiology Extensively Drug-Resistant Tuberculosis - prevention & control Extensively Drug-Resistant Tuberculosis - therapy Geography Human bacterial diseases Humans Infectious Disease Medicine - standards Infectious diseases Medical sciences Mycobacterium Pneumology Public Health Recurrence Treatment Outcome Tuberculosis and atypical mycobacterial infections Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - prevention & control Tuberculosis, Multidrug-Resistant - therapy World Health Organization |
| title | Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement |
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