Lack of G protein-coupled estrogen receptor (GPER) in the plasma membrane is associated with excellent long-term prognosis in breast cancer

G protein-coupled estrogen receptor (GPER), or GPR30, is a membrane receptor reported to mediate non-genomic estrogen responses. Tamoxifen is a partial agonist at GPER in vitro. Here, we investigated if GPER expression is prognostic in primary breast cancer, if the receptor is treatment-predictive f...

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Veröffentlicht in:	Breast cancer research and treatment 2014-05, Vol.145 (1), p.61-71
Hauptverfasser:	Sjöström, Martin, Hartman, Linda, Grabau, Dorthe, Fornander, Tommy, Malmström, Per, Nordenskjöld, Bo, Sgroi, Dennis C., Skoog, Lambert, Stål, Olle, Leeb-Lundberg, L. M. Fredrik, Fernö, Mårten
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents, Hormonal Biomarkers Biomarkers, Tumor - analysis Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - mortality Cancer and Oncology Cancer och onkologi Cancer research Cancer therapies Cell Membrane - chemistry Cell Membrane - metabolism Cell membranes Clinical Medicine Development and progression Disease-Free Survival Endocrine therapy Estrogen Estrogens Female G proteins Humans Immunohistochemistry Kaplan-Meier Estimate Klinisk medicin Medical and Health Sciences Medical prognosis MEDICIN Medicin och hälsovetenskap MEDICINE Medicine & Public Health Oncology Phenols Postmenopausal women Preclinical Study Prognosis Proportional Hazards Models Receptors, Estrogen - analysis Receptors, Estrogen - biosynthesis Receptors, G-Protein-Coupled - analysis Receptors, G-Protein-Coupled - biosynthesis Tamoxifen Tamoxifen - therapeutic use Tissue Array Analysis Treatment Outcome
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