Impacts of mobility disability and high and increasing body mass index on health-related quality of life and participation in society: a population-based cohort study from Sweden

Increasing obesity in adults with mobility disability has become a considerable health problem, similar to the increasing trend of obesity in the general population. The aims of this study were to investigate the association of mobility disability with overweight status and obesity in a large popula...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:BMC PUBLIC HEALTH 2014-04, Vol.14 (1), p.381-381, Article 381
Hauptverfasser: Holmgren, Marianne, Lindgren, Anna, de Munter, Jeroen, Rasmussen, Finn, Ahlström, Gerd
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 381
container_issue 1
container_start_page 381
container_title BMC PUBLIC HEALTH
container_volume 14
creator Holmgren, Marianne
Lindgren, Anna
de Munter, Jeroen
Rasmussen, Finn
Ahlström, Gerd
description Increasing obesity in adults with mobility disability has become a considerable health problem, similar to the increasing trend of obesity in the general population. The aims of this study were to investigate the association of mobility disability with overweight status and obesity in a large population-based Swedish cohort of adults, and to investigate whether mobility disability, high body mass index (BMI), and increasing BMI over time are predictors of health-related quality of life and participation in society after 8 years of follow-up. The study cohort included 13,549 individuals aged 18-64 years who answered questions about mobility disability, weight, height, health-related quality of life and participation in society in the Stockholm Public Health Survey 2002 and 2010. The cohort was randomly selected from the population of Stockholm County, and divided into six subgroups based on data for mobility disability and overweight status. Multiple binary logistic regression analyses were performed to assess the likelihood for low health-related quality of life and lack of participation. Respondents with mobility disability had a higher mean BMI than those without mobility disability. Respondents both with and without mobility disability increased in BMI, but with no significant difference in the longitudinal changes (mean difference: 0.078; 95% CI: -0.16 - 0.32). Presence of mobility disability increased the risk of low health-related quality of life and lack of participation in 2010, irrespective of low health-related quality of life and lack of participation in 2002. The risk of pain and low general health (parts of health-related quality of life) increased for every 5 units of higher BMI reported in 2010. In respondents without low general health at baseline, the risk of obtaining low general health increased for every 5 units of higher BMI in 2010 (OR:1.60; CI: 1.47 - 1.74). The greatest risk of low general health after 8 years was observed for respondents with both mobility disability and high BMI. These results indicate the importance of working preventively with persons with mobility disability and overweight status or obesity based on the risk of further weight gain.
doi_str_mv 10.1186/1471-2458-14-381
format Article
fullrecord <record><control><sourceid>gale_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_522165</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A539590920</galeid><sourcerecordid>A539590920</sourcerecordid><originalsourceid>FETCH-LOGICAL-b779t-14b341965d877f4babc3167d710d78262f6117ee5a25d16eda6d44ccb5b6f5a33</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7rp675UEvPGma5ImTeKFsAx-LAx4oV6HfHUm2jbdJnWdv-UvNJ2ZHXdgB6SEHk7e98nJ4aQoXiJ4iRCv3yLCUIkJ5SUiZcXRo-L8kHp8Lz4rnsX4A0LEOMVPizNMGMGYsvPiz3U3KJMiCA3ogvatTxtgfVT7UPUWrP1qvQ18b0anou9XQAe7AZ2KMSet-w1CD9ZOtWldjq5VyVlwM6ktIYNb37gtYFBj8sYPKvls8D2IwXiXNu-AAkMYpna7UWoVM8CEdRgTiGnKRzVj6MDXW2dd_7x40qg2uhf7_0Xx_eOHb4vP5fLLp-vF1bLUjImUO6IrgkRNLWesIVppU6GaWYagZRzXuKkRYs5RhalFtbOqtoQYo6muG6qq6qIod9x464ZJy2H0nRo3Migv96mfOXKSYoxqmvXipH4Yg_1nujMiLCpY5Vqyd3nS205DXjqv2cNEjSDBjWwoEZIgwqXWNZWICMo1z0DBM-79DpdZnbPG9WlU7XFFRzu9X8tV-CUJrGqGZ8BiB9A-nAAc75jQyXnc5DxuOZJ5GjPlzb6MMdxMLibZ-Whc26rehSlKRCvCCYNU_I8UE44onHv1eiddqdZJ3zchV2BmubyilaACCgyz6vIBVf6s67wJvWt8zh8Z4M5gxhDj6JrDbRGU82t76H6v7rf5YLh7XtVfU48onw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1532481506</pqid></control><display><type>article</type><title>Impacts of mobility disability and high and increasing body mass index on health-related quality of life and participation in society: a population-based cohort study from Sweden</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SWEPUB Freely available online</source><source>Springer Nature OA Free Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Holmgren, Marianne ; Lindgren, Anna ; de Munter, Jeroen ; Rasmussen, Finn ; Ahlström, Gerd</creator><creatorcontrib>Holmgren, Marianne ; Lindgren, Anna ; de Munter, Jeroen ; Rasmussen, Finn ; Ahlström, Gerd</creatorcontrib><description>Increasing obesity in adults with mobility disability has become a considerable health problem, similar to the increasing trend of obesity in the general population. The aims of this study were to investigate the association of mobility disability with overweight status and obesity in a large population-based Swedish cohort of adults, and to investigate whether mobility disability, high body mass index (BMI), and increasing BMI over time are predictors of health-related quality of life and participation in society after 8 years of follow-up. The study cohort included 13,549 individuals aged 18-64 years who answered questions about mobility disability, weight, height, health-related quality of life and participation in society in the Stockholm Public Health Survey 2002 and 2010. The cohort was randomly selected from the population of Stockholm County, and divided into six subgroups based on data for mobility disability and overweight status. Multiple binary logistic regression analyses were performed to assess the likelihood for low health-related quality of life and lack of participation. Respondents with mobility disability had a higher mean BMI than those without mobility disability. Respondents both with and without mobility disability increased in BMI, but with no significant difference in the longitudinal changes (mean difference: 0.078; 95% CI: -0.16 - 0.32). Presence of mobility disability increased the risk of low health-related quality of life and lack of participation in 2010, irrespective of low health-related quality of life and lack of participation in 2002. The risk of pain and low general health (parts of health-related quality of life) increased for every 5 units of higher BMI reported in 2010. In respondents without low general health at baseline, the risk of obtaining low general health increased for every 5 units of higher BMI in 2010 (OR:1.60; CI: 1.47 - 1.74). The greatest risk of low general health after 8 years was observed for respondents with both mobility disability and high BMI. These results indicate the importance of working preventively with persons with mobility disability and overweight status or obesity based on the risk of further weight gain.</description><identifier>ISSN: 1471-2458</identifier><identifier>EISSN: 1471-2458</identifier><identifier>DOI: 10.1186/1471-2458-14-381</identifier><identifier>PMID: 24742257</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Adult ; Analysis ; Body Mass Index ; Cohort Studies ; Disabled Persons ; Female ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; Health ; Health aspects ; Health Sciences ; Health Status ; Health Surveys ; Health-related quality of life (HRQoL) ; Humans ; Hälsovetenskap ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; Mobility disability ; Mobility Limitation ; Obesity ; Obesity - complications ; Overweight ; Pain - complications ; Participation ; Population study ; Prevalence ; Public health ; Public Health, Global Health, Social Medicine and Epidemiology ; Quality of Life ; Statistics ; Sweden ; Weight Gain ; Young Adult</subject><ispartof>BMC PUBLIC HEALTH, 2014-04, Vol.14 (1), p.381-381, Article 381</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>Copyright © 2014 Holmgren et al.; licensee BioMed Central Ltd. 2014 Holmgren et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b779t-14b341965d877f4babc3167d710d78262f6117ee5a25d16eda6d44ccb5b6f5a33</citedby><cites>FETCH-LOGICAL-b779t-14b341965d877f4babc3167d710d78262f6117ee5a25d16eda6d44ccb5b6f5a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036728/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036728/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24742257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/4608726$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:129303826$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Holmgren, Marianne</creatorcontrib><creatorcontrib>Lindgren, Anna</creatorcontrib><creatorcontrib>de Munter, Jeroen</creatorcontrib><creatorcontrib>Rasmussen, Finn</creatorcontrib><creatorcontrib>Ahlström, Gerd</creatorcontrib><title>Impacts of mobility disability and high and increasing body mass index on health-related quality of life and participation in society: a population-based cohort study from Sweden</title><title>BMC PUBLIC HEALTH</title><addtitle>BMC Public Health</addtitle><description>Increasing obesity in adults with mobility disability has become a considerable health problem, similar to the increasing trend of obesity in the general population. The aims of this study were to investigate the association of mobility disability with overweight status and obesity in a large population-based Swedish cohort of adults, and to investigate whether mobility disability, high body mass index (BMI), and increasing BMI over time are predictors of health-related quality of life and participation in society after 8 years of follow-up. The study cohort included 13,549 individuals aged 18-64 years who answered questions about mobility disability, weight, height, health-related quality of life and participation in society in the Stockholm Public Health Survey 2002 and 2010. The cohort was randomly selected from the population of Stockholm County, and divided into six subgroups based on data for mobility disability and overweight status. Multiple binary logistic regression analyses were performed to assess the likelihood for low health-related quality of life and lack of participation. Respondents with mobility disability had a higher mean BMI than those without mobility disability. Respondents both with and without mobility disability increased in BMI, but with no significant difference in the longitudinal changes (mean difference: 0.078; 95% CI: -0.16 - 0.32). Presence of mobility disability increased the risk of low health-related quality of life and lack of participation in 2010, irrespective of low health-related quality of life and lack of participation in 2002. The risk of pain and low general health (parts of health-related quality of life) increased for every 5 units of higher BMI reported in 2010. In respondents without low general health at baseline, the risk of obtaining low general health increased for every 5 units of higher BMI in 2010 (OR:1.60; CI: 1.47 - 1.74). The greatest risk of low general health after 8 years was observed for respondents with both mobility disability and high BMI. These results indicate the importance of working preventively with persons with mobility disability and overweight status or obesity based on the risk of further weight gain.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Body Mass Index</subject><subject>Cohort Studies</subject><subject>Disabled Persons</subject><subject>Female</subject><subject>Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi</subject><subject>Health</subject><subject>Health aspects</subject><subject>Health Sciences</subject><subject>Health Status</subject><subject>Health Surveys</subject><subject>Health-related quality of life (HRQoL)</subject><subject>Humans</subject><subject>Hälsovetenskap</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Mobility disability</subject><subject>Mobility Limitation</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Overweight</subject><subject>Pain - complications</subject><subject>Participation</subject><subject>Population study</subject><subject>Prevalence</subject><subject>Public health</subject><subject>Public Health, Global Health, Social Medicine and Epidemiology</subject><subject>Quality of Life</subject><subject>Statistics</subject><subject>Sweden</subject><subject>Weight Gain</subject><subject>Young Adult</subject><issn>1471-2458</issn><issn>1471-2458</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNk12L1DAUhoso7rp675UEvPGma5ImTeKFsAx-LAx4oV6HfHUm2jbdJnWdv-UvNJ2ZHXdgB6SEHk7e98nJ4aQoXiJ4iRCv3yLCUIkJ5SUiZcXRo-L8kHp8Lz4rnsX4A0LEOMVPizNMGMGYsvPiz3U3KJMiCA3ogvatTxtgfVT7UPUWrP1qvQ18b0anou9XQAe7AZ2KMSet-w1CD9ZOtWldjq5VyVlwM6ktIYNb37gtYFBj8sYPKvls8D2IwXiXNu-AAkMYpna7UWoVM8CEdRgTiGnKRzVj6MDXW2dd_7x40qg2uhf7_0Xx_eOHb4vP5fLLp-vF1bLUjImUO6IrgkRNLWesIVppU6GaWYagZRzXuKkRYs5RhalFtbOqtoQYo6muG6qq6qIod9x464ZJy2H0nRo3Migv96mfOXKSYoxqmvXipH4Yg_1nujMiLCpY5Vqyd3nS205DXjqv2cNEjSDBjWwoEZIgwqXWNZWICMo1z0DBM-79DpdZnbPG9WlU7XFFRzu9X8tV-CUJrGqGZ8BiB9A-nAAc75jQyXnc5DxuOZJ5GjPlzb6MMdxMLibZ-Whc26rehSlKRCvCCYNU_I8UE44onHv1eiddqdZJ3zchV2BmubyilaACCgyz6vIBVf6s67wJvWt8zh8Z4M5gxhDj6JrDbRGU82t76H6v7rf5YLh7XtVfU48onw</recordid><startdate>20140417</startdate><enddate>20140417</enddate><creator>Holmgren, Marianne</creator><creator>Lindgren, Anna</creator><creator>de Munter, Jeroen</creator><creator>Rasmussen, Finn</creator><creator>Ahlström, Gerd</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7TS</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AGCHP</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D95</scope><scope>ZZAVC</scope></search><sort><creationdate>20140417</creationdate><title>Impacts of mobility disability and high and increasing body mass index on health-related quality of life and participation in society: a population-based cohort study from Sweden</title><author>Holmgren, Marianne ; Lindgren, Anna ; de Munter, Jeroen ; Rasmussen, Finn ; Ahlström, Gerd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b779t-14b341965d877f4babc3167d710d78262f6117ee5a25d16eda6d44ccb5b6f5a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis</topic><topic>Body Mass Index</topic><topic>Cohort Studies</topic><topic>Disabled Persons</topic><topic>Female</topic><topic>Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi</topic><topic>Health</topic><topic>Health aspects</topic><topic>Health Sciences</topic><topic>Health Status</topic><topic>Health Surveys</topic><topic>Health-related quality of life (HRQoL)</topic><topic>Humans</topic><topic>Hälsovetenskap</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Mobility disability</topic><topic>Mobility Limitation</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Overweight</topic><topic>Pain - complications</topic><topic>Participation</topic><topic>Population study</topic><topic>Prevalence</topic><topic>Public health</topic><topic>Public Health, Global Health, Social Medicine and Epidemiology</topic><topic>Quality of Life</topic><topic>Statistics</topic><topic>Sweden</topic><topic>Weight Gain</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holmgren, Marianne</creatorcontrib><creatorcontrib>Lindgren, Anna</creatorcontrib><creatorcontrib>de Munter, Jeroen</creatorcontrib><creatorcontrib>Rasmussen, Finn</creatorcontrib><creatorcontrib>Ahlström, Gerd</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Physical Education Index</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Lunds universitet</collection><collection>SwePub Articles full text</collection><jtitle>BMC PUBLIC HEALTH</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holmgren, Marianne</au><au>Lindgren, Anna</au><au>de Munter, Jeroen</au><au>Rasmussen, Finn</au><au>Ahlström, Gerd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impacts of mobility disability and high and increasing body mass index on health-related quality of life and participation in society: a population-based cohort study from Sweden</atitle><jtitle>BMC PUBLIC HEALTH</jtitle><addtitle>BMC Public Health</addtitle><date>2014-04-17</date><risdate>2014</risdate><volume>14</volume><issue>1</issue><spage>381</spage><epage>381</epage><pages>381-381</pages><artnum>381</artnum><issn>1471-2458</issn><eissn>1471-2458</eissn><abstract>Increasing obesity in adults with mobility disability has become a considerable health problem, similar to the increasing trend of obesity in the general population. The aims of this study were to investigate the association of mobility disability with overweight status and obesity in a large population-based Swedish cohort of adults, and to investigate whether mobility disability, high body mass index (BMI), and increasing BMI over time are predictors of health-related quality of life and participation in society after 8 years of follow-up. The study cohort included 13,549 individuals aged 18-64 years who answered questions about mobility disability, weight, height, health-related quality of life and participation in society in the Stockholm Public Health Survey 2002 and 2010. The cohort was randomly selected from the population of Stockholm County, and divided into six subgroups based on data for mobility disability and overweight status. Multiple binary logistic regression analyses were performed to assess the likelihood for low health-related quality of life and lack of participation. Respondents with mobility disability had a higher mean BMI than those without mobility disability. Respondents both with and without mobility disability increased in BMI, but with no significant difference in the longitudinal changes (mean difference: 0.078; 95% CI: -0.16 - 0.32). Presence of mobility disability increased the risk of low health-related quality of life and lack of participation in 2010, irrespective of low health-related quality of life and lack of participation in 2002. The risk of pain and low general health (parts of health-related quality of life) increased for every 5 units of higher BMI reported in 2010. In respondents without low general health at baseline, the risk of obtaining low general health increased for every 5 units of higher BMI in 2010 (OR:1.60; CI: 1.47 - 1.74). The greatest risk of low general health after 8 years was observed for respondents with both mobility disability and high BMI. These results indicate the importance of working preventively with persons with mobility disability and overweight status or obesity based on the risk of further weight gain.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24742257</pmid><doi>10.1186/1471-2458-14-381</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1471-2458
ispartof BMC PUBLIC HEALTH, 2014-04, Vol.14 (1), p.381-381, Article 381
issn 1471-2458
1471-2458
language eng
recordid cdi_swepub_primary_oai_swepub_ki_se_522165
source MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Springer Nature OA Free Journals; PubMed Central; SpringerLink Journals - AutoHoldings
subjects Adolescent
Adult
Analysis
Body Mass Index
Cohort Studies
Disabled Persons
Female
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Health
Health aspects
Health Sciences
Health Status
Health Surveys
Health-related quality of life (HRQoL)
Humans
Hälsovetenskap
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Middle Aged
Mobility disability
Mobility Limitation
Obesity
Obesity - complications
Overweight
Pain - complications
Participation
Population study
Prevalence
Public health
Public Health, Global Health, Social Medicine and Epidemiology
Quality of Life
Statistics
Sweden
Weight Gain
Young Adult
title Impacts of mobility disability and high and increasing body mass index on health-related quality of life and participation in society: a population-based cohort study from Sweden
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T05%3A39%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impacts%20of%20mobility%20disability%20and%20high%20and%20increasing%20body%20mass%20index%20on%20health-related%20quality%20of%20life%20and%20participation%20in%20society:%20a%20population-based%20cohort%20study%20from%20Sweden&rft.jtitle=BMC%20PUBLIC%20HEALTH&rft.au=Holmgren,%20Marianne&rft.date=2014-04-17&rft.volume=14&rft.issue=1&rft.spage=381&rft.epage=381&rft.pages=381-381&rft.artnum=381&rft.issn=1471-2458&rft.eissn=1471-2458&rft_id=info:doi/10.1186/1471-2458-14-381&rft_dat=%3Cgale_swepu%3EA539590920%3C/gale_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1532481506&rft_id=info:pmid/24742257&rft_galeid=A539590920&rfr_iscdi=true