Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly

The steady and dramatic increase in the incidence of Alzheimer’s disease (AD) and the lack of effective treatments have stimulated the search for strategies to prevent or delay its onset and/or progression. Since the diagnosis of dementia requires a number of established features that are present wh...

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Veröffentlicht in:BioMed research international 2014-01, Vol.2014 (2014), p.1-14
Hauptverfasser: Rossi, Paolo D., Maccarrone, Mauro, Mari, Daniela, Arosio, Beatrice, Nicolini, Paola, Ferri, Evelyn, Tedone, Enzo, D'Addario, Claudio, Gussago, Cristina, Casati, Martina
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container_end_page 14
container_issue 2014
container_start_page 1
container_title BioMed research international
container_volume 2014
creator Rossi, Paolo D.
Maccarrone, Mauro
Mari, Daniela
Arosio, Beatrice
Nicolini, Paola
Ferri, Evelyn
Tedone, Enzo
D'Addario, Claudio
Gussago, Cristina
Casati, Martina
description The steady and dramatic increase in the incidence of Alzheimer’s disease (AD) and the lack of effective treatments have stimulated the search for strategies to prevent or delay its onset and/or progression. Since the diagnosis of dementia requires a number of established features that are present when the disease is fully developed, but not always in the early stages, the need for a biological marker has proven to be urgent, in terms of both diagnosis and monitoring of AD. AD has been shown to affect peripheral blood mononuclear cells (PBMCs) that are a critical component of the immune system which provide defence against infection. Although studies are continuously supplying additional data that emphasize the central role of inflammation in AD, PBMCs have not been sufficiently investigated in this context. Delineating biochemical alterations in AD blood constituents may prove valuable in identifying accessible footprints that reflect degenerative processes within the Central Nervous System (CNS). In this review, we address the role of biomarkers in AD with a focus on the notion that PBMCs may serve as a peripheral laboratory to find molecular signatures that could aid in differential diagnosis with other forms of dementia and in monitoring of disease progression.
doi_str_mv 10.1155/2014/169203
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Since the diagnosis of dementia requires a number of established features that are present when the disease is fully developed, but not always in the early stages, the need for a biological marker has proven to be urgent, in terms of both diagnosis and monitoring of AD. AD has been shown to affect peripheral blood mononuclear cells (PBMCs) that are a critical component of the immune system which provide defence against infection. Although studies are continuously supplying additional data that emphasize the central role of inflammation in AD, PBMCs have not been sufficiently investigated in this context. Delineating biochemical alterations in AD blood constituents may prove valuable in identifying accessible footprints that reflect degenerative processes within the Central Nervous System (CNS). 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Since the diagnosis of dementia requires a number of established features that are present when the disease is fully developed, but not always in the early stages, the need for a biological marker has proven to be urgent, in terms of both diagnosis and monitoring of AD. AD has been shown to affect peripheral blood mononuclear cells (PBMCs) that are a critical component of the immune system which provide defence against infection. Although studies are continuously supplying additional data that emphasize the central role of inflammation in AD, PBMCs have not been sufficiently investigated in this context. Delineating biochemical alterations in AD blood constituents may prove valuable in identifying accessible footprints that reflect degenerative processes within the Central Nervous System (CNS). 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subjects Aged
Aged, 80 and over
Alzheimer Disease - blood
Alzheimer Disease - diagnosis
Alzheimer Disease - pathology
Alzheimer's disease
Biological markers
Biomarkers
Biomarkers - blood
Blood
Blood cells
Brain research
Central Nervous System - metabolism
Central Nervous System - pathology
Development and progression
Diagnosis
Diagnosis, Differential
Disease Progression
Health aspects
Humans
Identification and classification
Inflammation - blood
Inflammation - diagnosis
Inflammation - pathology
Leukocytes, Mononuclear - metabolism
Leukocytes, Mononuclear - pathology
Monitoring, Physiologic - methods
Pathogenesis
Psychological aspects
Review
Studies
title Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly
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