Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
Background: Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in...
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| Veröffentlicht in: | British journal of cancer 2014-08, Vol.111 (5), p.987-997 |
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| creator | Obón-Santacana, M Kaaks, R Slimani, N Lujan-Barroso, L Freisling, H Ferrari, P Dossus, L Chabbert-Buffet, N Baglietto, L Fortner, R T Boeing, H Tjønneland, A Olsen, A Overvad, K Menéndez, V Molina-Montes, E Larrañaga, N Chirlaque, M-D Ardanaz, E Khaw, K-T Wareham, N Travis, R C Lu, Y Merritt, M A Trichopoulou, A Benetou, V Trichopoulos, D Saieva, C Sieri, S Tumino, R Sacerdote, C Galasso, R Bueno-de-Mesquita, H B Wirfält, E Ericson, U Idahl, A Ohlson, N Skeie, G Gram, I T Weiderpass, E Onland-Moret, N C Riboli, E Duell, E J |
| description | Background:
Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.
Methods:
Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.
Results:
No associations were observed between acrylamide intake and overall EC (
n
=1382) or type-I EC risk (
n
=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HR
Q5vsQ1
: 1.97, 95% CI: 1.08–3.62; likelihood ratio test (LRT)
P
-value: 0.01,
n
=203).
Conclusions:
Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers. |
| doi_str_mv | 10.1038/bjc.2014.328 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_520869</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3414106991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c759t-79ab04fb888e061dec0e7a81832637bf1879759d59c25416a87fd130e8c81c033</originalsourceid><addsrcrecordid>eNp1Uk2P0zAQjRCILQs3zigS4kaKP5LYviCtugusVAEH4Go5zqR1m9pdJynaM3-cybZ0uxJ7GCX2vPdmxvOS5DUlU0q4_FCt7JQRmk85k0-SCS04y6hk4mkyIYSIjChGzpIXXbfCoyJSPE_OWK64KMtikvy5dNCbeJs635s1pKFJjY23rdm4GlLj6xR8HTbQR2fa1BpvIabRdWskpP0S0qshhi0Yn36PoduC7d0O0mu_g653C9O74EfpkM721FHx64BqdxkbliH2L5NnjWk7eHX4nic_P139mH3J5t8-X88u5pkVheozoUxF8qaSUgIpaQ2WgDCSSs5KLqqGSqEQWBfKsiKnpZGiqSknIK2klnB-nmR73e43bIdKb6Pb4Og6GKcPV2v8A10wIkuF-Pmj-HbYYlQYI0FxqIrCEM0l5zpXtdFYFLSRqqyM4JXKGcq9f1Tu0v260CEu9LAZtMppkSP84x6O2A3UFnwfTfuA9TDj3VIvwk4jm7ByrEf3ArYbrI6Az29Nf0c8HsZgRDDNS8X4-ERvDhzcce-89iEaTQnhQgsmBALeHrqK4WbAJetVGKLHtWlaFCWTrJAno1o0RRehObZNiR5dq9G1enStRtfeV90PdAT_sykC3h0AprOmbSKayXX3OCkEyyU92TCm_ALiSXf_K_wXCnEFVQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1556282582</pqid></control><display><type>article</type><title>Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort</title><source>MEDLINE</source><source>NORA - Norwegian Open Research Archives</source><source>Recercat</source><source>SpringerLink Journals</source><source>Nature Journals Online</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><creator>Obón-Santacana, M ; Kaaks, R ; Slimani, N ; Lujan-Barroso, L ; Freisling, H ; Ferrari, P ; Dossus, L ; Chabbert-Buffet, N ; Baglietto, L ; Fortner, R T ; Boeing, H ; Tjønneland, A ; Olsen, A ; Overvad, K ; Menéndez, V ; Molina-Montes, E ; Larrañaga, N ; Chirlaque, M-D ; Ardanaz, E ; Khaw, K-T ; Wareham, N ; Travis, R C ; Lu, Y ; Merritt, M A ; Trichopoulou, A ; Benetou, V ; Trichopoulos, D ; Saieva, C ; Sieri, S ; Tumino, R ; Sacerdote, C ; Galasso, R ; Bueno-de-Mesquita, H B ; Wirfält, E ; Ericson, U ; Idahl, A ; Ohlson, N ; Skeie, G ; Gram, I T ; Weiderpass, E ; Onland-Moret, N C ; Riboli, E ; Duell, E J</creator><creatorcontrib>Obón-Santacana, M ; Kaaks, R ; Slimani, N ; Lujan-Barroso, L ; Freisling, H ; Ferrari, P ; Dossus, L ; Chabbert-Buffet, N ; Baglietto, L ; Fortner, R T ; Boeing, H ; Tjønneland, A ; Olsen, A ; Overvad, K ; Menéndez, V ; Molina-Montes, E ; Larrañaga, N ; Chirlaque, M-D ; Ardanaz, E ; Khaw, K-T ; Wareham, N ; Travis, R C ; Lu, Y ; Merritt, M A ; Trichopoulou, A ; Benetou, V ; Trichopoulos, D ; Saieva, C ; Sieri, S ; Tumino, R ; Sacerdote, C ; Galasso, R ; Bueno-de-Mesquita, H B ; Wirfält, E ; Ericson, U ; Idahl, A ; Ohlson, N ; Skeie, G ; Gram, I T ; Weiderpass, E ; Onland-Moret, N C ; Riboli, E ; Duell, E J</creatorcontrib><description>Background:
Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.
Methods:
Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.
Results:
No associations were observed between acrylamide intake and overall EC (
n
=1382) or type-I EC risk (
n
=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HR
Q5vsQ1
: 1.97, 95% CI: 1.08–3.62; likelihood ratio test (LRT)
P
-value: 0.01,
n
=203).
Conclusions:
Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.</description><identifier>ISSN: 0007-0920</identifier><identifier>ISSN: 1532-1827</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2014.328</identifier><identifier>PMID: 24937665</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/67/1517/1931 ; 692/699/67/2324 ; acrylamide ; Acrylamide - adverse effects ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Cancer and Oncology ; Cancer och onkologi ; Cancer Research ; Clinical medical disciplines: 750 ; Clinical Medicine ; cohort ; Cohort Studies ; Càncer d'endometri ; Diet - methods ; Drug Resistance ; Eating - physiology ; Eating disorders ; Efectes secundaris ; Endometrial cancer ; Endometrial Neoplasms - etiology ; Epidemiology ; Ernæring: 811 ; Etiologia ; Etiology ; Female ; Female genital diseases ; Fisiologia ; Gynecology ; Gynecology. Andrology. Obstetrics ; Health sciences ; Health sciences: 800 ; Helsefag: 800 ; Humans ; Klinisk medicin ; Klinisk medisinske fag: 750 ; Medical and Health Sciences ; Medical disciplines: 700 ; Medical research ; Medical sciences ; Medicin och hälsovetenskap ; Medisinske Fag: 700 ; Middle Aged ; Molecular Medicine ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Nutrition ; Nutrition: 811 ; Nutritional Status - physiology ; Oncology ; Oncology: 762 ; Onkologi: 762 ; Physiology ; Prospective Studies ; Public health ; Research centers ; Risk ; Risk Factors ; Side effects ; Smoking - adverse effects ; Trastorns de la conducta alimentària ; Tumors ; type-I endometrial cancer ; VDP</subject><ispartof>British journal of cancer, 2014-08, Vol.111 (5), p.987-997</ispartof><rights>The Author(s) 2014</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Aug 26, 2014</rights><rights>info:eu-repo/semantics/openAccess</rights><rights>(c) Obón Santacana, Mireia et al., 2014 info:eu-repo/semantics/openAccess</rights><rights>Copyright © 2014 Cancer Research UK 2014 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c759t-79ab04fb888e061dec0e7a81832637bf1879759d59c25416a87fd130e8c81c033</citedby><cites>FETCH-LOGICAL-c759t-79ab04fb888e061dec0e7a81832637bf1879759d59c25416a87fd130e8c81c033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150262/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150262/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,881,26544,26951,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28772481$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24937665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-94154$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/4528309$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:129681846$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Obón-Santacana, M</creatorcontrib><creatorcontrib>Kaaks, R</creatorcontrib><creatorcontrib>Slimani, N</creatorcontrib><creatorcontrib>Lujan-Barroso, L</creatorcontrib><creatorcontrib>Freisling, H</creatorcontrib><creatorcontrib>Ferrari, P</creatorcontrib><creatorcontrib>Dossus, L</creatorcontrib><creatorcontrib>Chabbert-Buffet, N</creatorcontrib><creatorcontrib>Baglietto, L</creatorcontrib><creatorcontrib>Fortner, R T</creatorcontrib><creatorcontrib>Boeing, H</creatorcontrib><creatorcontrib>Tjønneland, A</creatorcontrib><creatorcontrib>Olsen, A</creatorcontrib><creatorcontrib>Overvad, K</creatorcontrib><creatorcontrib>Menéndez, V</creatorcontrib><creatorcontrib>Molina-Montes, E</creatorcontrib><creatorcontrib>Larrañaga, N</creatorcontrib><creatorcontrib>Chirlaque, M-D</creatorcontrib><creatorcontrib>Ardanaz, E</creatorcontrib><creatorcontrib>Khaw, K-T</creatorcontrib><creatorcontrib>Wareham, N</creatorcontrib><creatorcontrib>Travis, R C</creatorcontrib><creatorcontrib>Lu, Y</creatorcontrib><creatorcontrib>Merritt, M A</creatorcontrib><creatorcontrib>Trichopoulou, A</creatorcontrib><creatorcontrib>Benetou, V</creatorcontrib><creatorcontrib>Trichopoulos, D</creatorcontrib><creatorcontrib>Saieva, C</creatorcontrib><creatorcontrib>Sieri, S</creatorcontrib><creatorcontrib>Tumino, R</creatorcontrib><creatorcontrib>Sacerdote, C</creatorcontrib><creatorcontrib>Galasso, R</creatorcontrib><creatorcontrib>Bueno-de-Mesquita, H B</creatorcontrib><creatorcontrib>Wirfält, E</creatorcontrib><creatorcontrib>Ericson, U</creatorcontrib><creatorcontrib>Idahl, A</creatorcontrib><creatorcontrib>Ohlson, N</creatorcontrib><creatorcontrib>Skeie, G</creatorcontrib><creatorcontrib>Gram, I T</creatorcontrib><creatorcontrib>Weiderpass, E</creatorcontrib><creatorcontrib>Onland-Moret, N C</creatorcontrib><creatorcontrib>Riboli, E</creatorcontrib><creatorcontrib>Duell, E J</creatorcontrib><title>Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.
Methods:
Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.
Results:
No associations were observed between acrylamide intake and overall EC (
n
=1382) or type-I EC risk (
n
=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HR
Q5vsQ1
: 1.97, 95% CI: 1.08–3.62; likelihood ratio test (LRT)
P
-value: 0.01,
n
=203).
Conclusions:
Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.</description><subject>692/499</subject><subject>692/699/67/1517/1931</subject><subject>692/699/67/2324</subject><subject>acrylamide</subject><subject>Acrylamide - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer and Oncology</subject><subject>Cancer och onkologi</subject><subject>Cancer Research</subject><subject>Clinical medical disciplines: 750</subject><subject>Clinical Medicine</subject><subject>cohort</subject><subject>Cohort Studies</subject><subject>Càncer d'endometri</subject><subject>Diet - methods</subject><subject>Drug Resistance</subject><subject>Eating - physiology</subject><subject>Eating disorders</subject><subject>Efectes secundaris</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - etiology</subject><subject>Epidemiology</subject><subject>Ernæring: 811</subject><subject>Etiologia</subject><subject>Etiology</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Fisiologia</subject><subject>Gynecology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health sciences</subject><subject>Health sciences: 800</subject><subject>Helsefag: 800</subject><subject>Humans</subject><subject>Klinisk medicin</subject><subject>Klinisk medisinske fag: 750</subject><subject>Medical and Health Sciences</subject><subject>Medical disciplines: 700</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Medisinske Fag: 700</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Nutrition</subject><subject>Nutrition: 811</subject><subject>Nutritional Status - physiology</subject><subject>Oncology</subject><subject>Oncology: 762</subject><subject>Onkologi: 762</subject><subject>Physiology</subject><subject>Prospective Studies</subject><subject>Public health</subject><subject>Research centers</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Side effects</subject><subject>Smoking - adverse effects</subject><subject>Trastorns de la conducta alimentària</subject><subject>Tumors</subject><subject>type-I endometrial cancer</subject><subject>VDP</subject><issn>0007-0920</issn><issn>1532-1827</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>3HK</sourceid><sourceid>XX2</sourceid><sourceid>D8T</sourceid><recordid>eNp1Uk2P0zAQjRCILQs3zigS4kaKP5LYviCtugusVAEH4Go5zqR1m9pdJynaM3-cybZ0uxJ7GCX2vPdmxvOS5DUlU0q4_FCt7JQRmk85k0-SCS04y6hk4mkyIYSIjChGzpIXXbfCoyJSPE_OWK64KMtikvy5dNCbeJs635s1pKFJjY23rdm4GlLj6xR8HTbQR2fa1BpvIabRdWskpP0S0qshhi0Yn36PoduC7d0O0mu_g653C9O74EfpkM721FHx64BqdxkbliH2L5NnjWk7eHX4nic_P139mH3J5t8-X88u5pkVheozoUxF8qaSUgIpaQ2WgDCSSs5KLqqGSqEQWBfKsiKnpZGiqSknIK2klnB-nmR73e43bIdKb6Pb4Og6GKcPV2v8A10wIkuF-Pmj-HbYYlQYI0FxqIrCEM0l5zpXtdFYFLSRqqyM4JXKGcq9f1Tu0v260CEu9LAZtMppkSP84x6O2A3UFnwfTfuA9TDj3VIvwk4jm7ByrEf3ArYbrI6Az29Nf0c8HsZgRDDNS8X4-ERvDhzcce-89iEaTQnhQgsmBALeHrqK4WbAJetVGKLHtWlaFCWTrJAno1o0RRehObZNiR5dq9G1enStRtfeV90PdAT_sykC3h0AprOmbSKayXX3OCkEyyU92TCm_ALiSXf_K_wXCnEFVQ</recordid><startdate>20140826</startdate><enddate>20140826</enddate><creator>Obón-Santacana, M</creator><creator>Kaaks, R</creator><creator>Slimani, N</creator><creator>Lujan-Barroso, L</creator><creator>Freisling, H</creator><creator>Ferrari, P</creator><creator>Dossus, L</creator><creator>Chabbert-Buffet, N</creator><creator>Baglietto, L</creator><creator>Fortner, R T</creator><creator>Boeing, H</creator><creator>Tjønneland, A</creator><creator>Olsen, A</creator><creator>Overvad, K</creator><creator>Menéndez, V</creator><creator>Molina-Montes, E</creator><creator>Larrañaga, N</creator><creator>Chirlaque, M-D</creator><creator>Ardanaz, E</creator><creator>Khaw, K-T</creator><creator>Wareham, N</creator><creator>Travis, R C</creator><creator>Lu, Y</creator><creator>Merritt, M A</creator><creator>Trichopoulou, A</creator><creator>Benetou, V</creator><creator>Trichopoulos, D</creator><creator>Saieva, C</creator><creator>Sieri, S</creator><creator>Tumino, R</creator><creator>Sacerdote, C</creator><creator>Galasso, R</creator><creator>Bueno-de-Mesquita, H B</creator><creator>Wirfält, E</creator><creator>Ericson, U</creator><creator>Idahl, A</creator><creator>Ohlson, N</creator><creator>Skeie, G</creator><creator>Gram, I T</creator><creator>Weiderpass, E</creator><creator>Onland-Moret, N C</creator><creator>Riboli, E</creator><creator>Duell, E J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Cancer Research UK</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>3HK</scope><scope>XX2</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D93</scope><scope>AGCHP</scope><scope>D8T</scope><scope>D95</scope><scope>ZZAVC</scope></search><sort><creationdate>20140826</creationdate><title>Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort</title><author>Obón-Santacana, M ; Kaaks, R ; Slimani, N ; Lujan-Barroso, L ; Freisling, H ; Ferrari, P ; Dossus, L ; Chabbert-Buffet, N ; Baglietto, L ; Fortner, R T ; Boeing, H ; Tjønneland, A ; Olsen, A ; Overvad, K ; Menéndez, V ; Molina-Montes, E ; Larrañaga, N ; Chirlaque, M-D ; Ardanaz, E ; Khaw, K-T ; Wareham, N ; Travis, R C ; Lu, Y ; Merritt, M A ; Trichopoulou, A ; Benetou, V ; Trichopoulos, D ; Saieva, C ; Sieri, S ; Tumino, R ; Sacerdote, C ; Galasso, R ; Bueno-de-Mesquita, H B ; Wirfält, E ; Ericson, U ; Idahl, A ; Ohlson, N ; Skeie, G ; Gram, I T ; Weiderpass, E ; Onland-Moret, N C ; Riboli, E ; Duell, E J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c759t-79ab04fb888e061dec0e7a81832637bf1879759d59c25416a87fd130e8c81c033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>692/499</topic><topic>692/699/67/1517/1931</topic><topic>692/699/67/2324</topic><topic>acrylamide</topic><topic>Acrylamide - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer and Oncology</topic><topic>Cancer och onkologi</topic><topic>Cancer Research</topic><topic>Clinical medical disciplines: 750</topic><topic>Clinical Medicine</topic><topic>cohort</topic><topic>Cohort Studies</topic><topic>Càncer d'endometri</topic><topic>Diet - methods</topic><topic>Drug Resistance</topic><topic>Eating - physiology</topic><topic>Eating disorders</topic><topic>Efectes secundaris</topic><topic>Endometrial cancer</topic><topic>Endometrial Neoplasms - etiology</topic><topic>Epidemiology</topic><topic>Ernæring: 811</topic><topic>Etiologia</topic><topic>Etiology</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Fisiologia</topic><topic>Gynecology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Health sciences</topic><topic>Health sciences: 800</topic><topic>Helsefag: 800</topic><topic>Humans</topic><topic>Klinisk medicin</topic><topic>Klinisk medisinske fag: 750</topic><topic>Medical and Health Sciences</topic><topic>Medical disciplines: 700</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Medisinske Fag: 700</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Nutrition</topic><topic>Nutrition: 811</topic><topic>Nutritional Status - physiology</topic><topic>Oncology</topic><topic>Oncology: 762</topic><topic>Onkologi: 762</topic><topic>Physiology</topic><topic>Prospective Studies</topic><topic>Public health</topic><topic>Research centers</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Side effects</topic><topic>Smoking - adverse effects</topic><topic>Trastorns de la conducta alimentària</topic><topic>Tumors</topic><topic>type-I endometrial cancer</topic><topic>VDP</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obón-Santacana, M</creatorcontrib><creatorcontrib>Kaaks, R</creatorcontrib><creatorcontrib>Slimani, N</creatorcontrib><creatorcontrib>Lujan-Barroso, L</creatorcontrib><creatorcontrib>Freisling, H</creatorcontrib><creatorcontrib>Ferrari, P</creatorcontrib><creatorcontrib>Dossus, L</creatorcontrib><creatorcontrib>Chabbert-Buffet, N</creatorcontrib><creatorcontrib>Baglietto, L</creatorcontrib><creatorcontrib>Fortner, R T</creatorcontrib><creatorcontrib>Boeing, H</creatorcontrib><creatorcontrib>Tjønneland, A</creatorcontrib><creatorcontrib>Olsen, A</creatorcontrib><creatorcontrib>Overvad, K</creatorcontrib><creatorcontrib>Menéndez, V</creatorcontrib><creatorcontrib>Molina-Montes, E</creatorcontrib><creatorcontrib>Larrañaga, N</creatorcontrib><creatorcontrib>Chirlaque, M-D</creatorcontrib><creatorcontrib>Ardanaz, E</creatorcontrib><creatorcontrib>Khaw, K-T</creatorcontrib><creatorcontrib>Wareham, N</creatorcontrib><creatorcontrib>Travis, R C</creatorcontrib><creatorcontrib>Lu, Y</creatorcontrib><creatorcontrib>Merritt, M A</creatorcontrib><creatorcontrib>Trichopoulou, A</creatorcontrib><creatorcontrib>Benetou, V</creatorcontrib><creatorcontrib>Trichopoulos, D</creatorcontrib><creatorcontrib>Saieva, C</creatorcontrib><creatorcontrib>Sieri, S</creatorcontrib><creatorcontrib>Tumino, R</creatorcontrib><creatorcontrib>Sacerdote, C</creatorcontrib><creatorcontrib>Galasso, R</creatorcontrib><creatorcontrib>Bueno-de-Mesquita, H B</creatorcontrib><creatorcontrib>Wirfält, E</creatorcontrib><creatorcontrib>Ericson, U</creatorcontrib><creatorcontrib>Idahl, A</creatorcontrib><creatorcontrib>Ohlson, N</creatorcontrib><creatorcontrib>Skeie, G</creatorcontrib><creatorcontrib>Gram, I T</creatorcontrib><creatorcontrib>Weiderpass, E</creatorcontrib><creatorcontrib>Onland-Moret, N C</creatorcontrib><creatorcontrib>Riboli, E</creatorcontrib><creatorcontrib>Duell, E J</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>Recercat</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Umeå universitet</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Lunds universitet</collection><collection>SwePub Articles full text</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obón-Santacana, M</au><au>Kaaks, R</au><au>Slimani, N</au><au>Lujan-Barroso, L</au><au>Freisling, H</au><au>Ferrari, P</au><au>Dossus, L</au><au>Chabbert-Buffet, N</au><au>Baglietto, L</au><au>Fortner, R T</au><au>Boeing, H</au><au>Tjønneland, A</au><au>Olsen, A</au><au>Overvad, K</au><au>Menéndez, V</au><au>Molina-Montes, E</au><au>Larrañaga, N</au><au>Chirlaque, M-D</au><au>Ardanaz, E</au><au>Khaw, K-T</au><au>Wareham, N</au><au>Travis, R C</au><au>Lu, Y</au><au>Merritt, M A</au><au>Trichopoulou, A</au><au>Benetou, V</au><au>Trichopoulos, D</au><au>Saieva, C</au><au>Sieri, S</au><au>Tumino, R</au><au>Sacerdote, C</au><au>Galasso, R</au><au>Bueno-de-Mesquita, H B</au><au>Wirfält, E</au><au>Ericson, U</au><au>Idahl, A</au><au>Ohlson, N</au><au>Skeie, G</au><au>Gram, I T</au><au>Weiderpass, E</au><au>Onland-Moret, N C</au><au>Riboli, E</au><au>Duell, E J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2014-08-26</date><risdate>2014</risdate><volume>111</volume><issue>5</issue><spage>987</spage><epage>997</epage><pages>987-997</pages><issn>0007-0920</issn><issn>1532-1827</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.
Methods:
Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.
Results:
No associations were observed between acrylamide intake and overall EC (
n
=1382) or type-I EC risk (
n
=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HR
Q5vsQ1
: 1.97, 95% CI: 1.08–3.62; likelihood ratio test (LRT)
P
-value: 0.01,
n
=203).
Conclusions:
Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24937665</pmid><doi>10.1038/bjc.2014.328</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2014-08, Vol.111 (5), p.987-997 |
| issn | 0007-0920 1532-1827 1532-1827 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_520869 |
| source | MEDLINE; NORA - Norwegian Open Research Archives; Recercat; SpringerLink Journals; Nature Journals Online; EZB-FREE-00999 freely available EZB journals; PubMed Central; SWEPUB Freely available online |
| subjects | 692/499 692/699/67/1517/1931 692/699/67/2324 acrylamide Acrylamide - adverse effects Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer and Oncology Cancer och onkologi Cancer Research Clinical medical disciplines: 750 Clinical Medicine cohort Cohort Studies Càncer d'endometri Diet - methods Drug Resistance Eating - physiology Eating disorders Efectes secundaris Endometrial cancer Endometrial Neoplasms - etiology Epidemiology Ernæring: 811 Etiologia Etiology Female Female genital diseases Fisiologia Gynecology Gynecology. Andrology. Obstetrics Health sciences Health sciences: 800 Helsefag: 800 Humans Klinisk medicin Klinisk medisinske fag: 750 Medical and Health Sciences Medical disciplines: 700 Medical research Medical sciences Medicin och hälsovetenskap Medisinske Fag: 700 Middle Aged Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nutrition Nutrition: 811 Nutritional Status - physiology Oncology Oncology: 762 Onkologi: 762 Physiology Prospective Studies Public health Research centers Risk Risk Factors Side effects Smoking - adverse effects Trastorns de la conducta alimentària Tumors type-I endometrial cancer VDP |
| title | Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort |
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