The receptor tyrosine kinase ROR1 – An oncofetal antigen for targeted cancer therapy

Abstract Targeted cancer therapies have emerged as new treatment options for various cancer types. Among targets, receptor tyrosine kinases (RTKs) are among the most promising. ROR1 is a transmembrane RTK of importance during the normal embryogenesis for the central nervous system, heart, lung and s...

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Veröffentlicht in:	Seminars in cancer biology 2014-12, Vol.29, p.21-31
Hauptverfasser:	Hojjat-Farsangi, Mohammad, Moshfegh, Ali, Daneshmanesh, Amir Hossein, Khan, Abdul Salam, Mikaelsson, Eva, Österborg, Anders, Mellstedt, Håkan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism Cancer therapy Embryonic Development Hematology, Oncology and Palliative Medicine Humans Immunotherapy, Active Medicin och hälsovetenskap Molecular Targeted Therapy Monoclonal antibodies Neoplasms - drug therapy Neoplasms - pathology Protein Isoforms - genetics Protein Kinase Inhibitors - therapeutic use Receptor Tyrosine Kinase-like Orphan Receptors - antagonists & inhibitors Receptor Tyrosine Kinase-like Orphan Receptors - biosynthesis Receptor Tyrosine Kinase-like Orphan Receptors - metabolism ROR1 Tyrosine kinase inhibitors
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