Effects of childhood abuse on adult obesity: a systematic review and meta‐analysis
Controversy exists surrounding the role of childhood abuse in obesity development. This is a meta‐analysis of observational studies on the role of childhood abuse in adult obesity. Systematic searches of PubMed, PsycInfo, Medline and CINAHL resulted in 23 cohort studies (4 prospective, 19 retrospect...
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| Veröffentlicht in: | Obesity reviews 2014-11, Vol.15 (11), p.882-893 |
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| description | Controversy exists surrounding the role of childhood abuse in obesity development. This is a meta‐analysis of observational studies on the role of childhood abuse in adult obesity. Systematic searches of PubMed, PsycInfo, Medline and CINAHL resulted in 23 cohort studies (4 prospective, 19 retrospective) with n = 112,708 participants, containing four abuse types (physical, emotional, sexual, general). Four studies reported dose–response effects. A random effects model was used to quantify effect sizes, meta‐regression/subgroup analysis for identifying potential moderating variables and Egger's test for publication bias. Adults who reported childhood abuse were significantly more likely to be obese (odds ratio [OR]: 1.34, 95% confidence interval [CI]: 1.24–1.45, P |
| doi_str_mv | 10.1111/obr.12216 |
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This is a meta‐analysis of observational studies on the role of childhood abuse in adult obesity. Systematic searches of PubMed, PsycInfo, Medline and CINAHL resulted in 23 cohort studies (4 prospective, 19 retrospective) with n = 112,708 participants, containing four abuse types (physical, emotional, sexual, general). Four studies reported dose–response effects. A random effects model was used to quantify effect sizes, meta‐regression/subgroup analysis for identifying potential moderating variables and Egger's test for publication bias. Adults who reported childhood abuse were significantly more likely to be obese (odds ratio [OR]: 1.34, 95% confidence interval [CI]: 1.24–1.45, P < 0.001). All four types of abuse were significantly associated with adult obesity: physical (OR: 1.28, 95% CI: 1.13–1.46), emotional (OR: 1.36, 95% CI: 1.08–1.71), sexual (OR: 1.31, 95% CI: 1.13–1.53) and general abuse (OR: 1.45, 95% CI: 1.25–1.69). Severe abuse (OR: 1.50, 95% CI: 1.27–1.77) was significantly more associated with adult obesity (P = 0.043) compared with light/moderate abuse (OR: 1.13, 95% CI: 0.91–1.41). We found no significant effects of study design (prospective vs. retrospective, P = 0.07), age (P = 0.96) or gender (P = 0.92). Publication bias was evident (Egger's test P = 0.007), but effect sizes remained statistically significant in sensitivity analyses. Childhood abuse was clearly associated with being obese as an adult, including a positive dose–response association. This suggests that adverse life experiences during childhood plays a major role in obesity development, potentially by inducing mental and emotional perturbations, maladaptive coping responses, stress, inflammation and metabolic disturbances.</description><identifier>ISSN: 1467-7881</identifier><identifier>ISSN: 1467-789X</identifier><identifier>EISSN: 1467-789X</identifier><identifier>DOI: 10.1111/obr.12216</identifier><identifier>PMID: 25123205</identifier><language>eng</language><publisher>England: Blackwell Pub</publisher><subject>Adaptation, Psychological ; Adult ; adults ; Age of Onset ; Child ; Child Abuse - psychology ; Child, Preschool ; childhood ; Childhood abuse ; cohort studies ; confidence interval ; experimental design ; gender ; Humans ; inflammation ; life events ; Mental Health ; meta-analysis ; obesity ; Obesity - etiology ; Obesity - psychology ; observational studies ; Observational Studies as Topic ; Odds Ratio ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Substance-Related Disorders - etiology ; Substance-Related Disorders - psychology ; systematic review ; Time Factors ; Weight Gain</subject><ispartof>Obesity reviews, 2014-11, Vol.15 (11), p.882-893</ispartof><rights>2014 World Obesity</rights><rights>2014 World Obesity.</rights><rights>Obesity Reviews © 2014 International Association for the Study of Obesity</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6256-588ad2b14be0f71cef5b71099964a1538c06a85a30a7552a6bc16c2c9d2a3c833</citedby><cites>FETCH-LOGICAL-c6256-588ad2b14be0f71cef5b71099964a1538c06a85a30a7552a6bc16c2c9d2a3c833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fobr.12216$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fobr.12216$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25123205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-4738$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:130055583$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Hemmingsson, E</creatorcontrib><creatorcontrib>Johansson, K</creatorcontrib><creatorcontrib>Reynisdottir, S</creatorcontrib><title>Effects of childhood abuse on adult obesity: a systematic review and meta‐analysis</title><title>Obesity reviews</title><addtitle>Obes Rev</addtitle><description>Controversy exists surrounding the role of childhood abuse in obesity development. This is a meta‐analysis of observational studies on the role of childhood abuse in adult obesity. Systematic searches of PubMed, PsycInfo, Medline and CINAHL resulted in 23 cohort studies (4 prospective, 19 retrospective) with n = 112,708 participants, containing four abuse types (physical, emotional, sexual, general). Four studies reported dose–response effects. A random effects model was used to quantify effect sizes, meta‐regression/subgroup analysis for identifying potential moderating variables and Egger's test for publication bias. Adults who reported childhood abuse were significantly more likely to be obese (odds ratio [OR]: 1.34, 95% confidence interval [CI]: 1.24–1.45, P < 0.001). All four types of abuse were significantly associated with adult obesity: physical (OR: 1.28, 95% CI: 1.13–1.46), emotional (OR: 1.36, 95% CI: 1.08–1.71), sexual (OR: 1.31, 95% CI: 1.13–1.53) and general abuse (OR: 1.45, 95% CI: 1.25–1.69). Severe abuse (OR: 1.50, 95% CI: 1.27–1.77) was significantly more associated with adult obesity (P = 0.043) compared with light/moderate abuse (OR: 1.13, 95% CI: 0.91–1.41). We found no significant effects of study design (prospective vs. retrospective, P = 0.07), age (P = 0.96) or gender (P = 0.92). Publication bias was evident (Egger's test P = 0.007), but effect sizes remained statistically significant in sensitivity analyses. Childhood abuse was clearly associated with being obese as an adult, including a positive dose–response association. This suggests that adverse life experiences during childhood plays a major role in obesity development, potentially by inducing mental and emotional perturbations, maladaptive coping responses, stress, inflammation and metabolic disturbances.</description><subject>Adaptation, Psychological</subject><subject>Adult</subject><subject>adults</subject><subject>Age of Onset</subject><subject>Child</subject><subject>Child Abuse - psychology</subject><subject>Child, Preschool</subject><subject>childhood</subject><subject>Childhood abuse</subject><subject>cohort studies</subject><subject>confidence interval</subject><subject>experimental design</subject><subject>gender</subject><subject>Humans</subject><subject>inflammation</subject><subject>life events</subject><subject>Mental Health</subject><subject>meta-analysis</subject><subject>obesity</subject><subject>Obesity - etiology</subject><subject>Obesity - psychology</subject><subject>observational studies</subject><subject>Observational Studies as Topic</subject><subject>Odds Ratio</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Substance-Related Disorders - etiology</subject><subject>Substance-Related Disorders - psychology</subject><subject>systematic review</subject><subject>Time Factors</subject><subject>Weight Gain</subject><issn>1467-7881</issn><issn>1467-789X</issn><issn>1467-789X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c1u1DAUBeAIgWgpLHgBsMQGhNL62rGTdFdKGRBVK-gPiI114zgzbjPjwU4YsuMReEaeBNNMZ4FUb2xZn4-se5LkKdBdiGvPVX4XGAN5L9mGTOZpXpRf72_OBWwlj0K4ohTyksPDZIsJYJxRsZ2cHzWN0V0griF6Ztt65lxNsOqDIW5BsO7bjrjKBNsN-wRJGEJn5thZTbz5Yc2K4KImc9Phn1-_cYHtEGx4nDxosA3myXrfSS7eHZ0fvk-PTycfDg-OUy2ZkKkoCqxZBVllaJODNo2ocqBlWcoMQfBCU4mFQE4xF4KhrDRIzXRZM-S64HwnScfcsDLLvlJLb-foB-XQqvXVdTwZJaAUpYz-9Z3-rb08UM5P1dTOVJbzIuqXo1569703oVNzG7RpW1wY1wcFEgSTlGUi0hf_0SvX-ziNG8VLiCqL6tWotHcheNNsPgBU_StSxSLVTZHRPlsn9tXc1Bt521wEeyNY2dYMdyep0zefbyPX07Kxwp-bF-ivlcx5LtSXk4n6dnKZfRRnn9Qk-uejb9ApnHob1MUZoyAopQUFLvhfj8fAJg</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Hemmingsson, E</creator><creator>Johansson, K</creator><creator>Reynisdottir, S</creator><general>Blackwell Pub</general><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TS</scope><scope>C1K</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF1</scope></search><sort><creationdate>201411</creationdate><title>Effects of childhood abuse on adult obesity: a systematic review and meta‐analysis</title><author>Hemmingsson, E ; Johansson, K ; Reynisdottir, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6256-588ad2b14be0f71cef5b71099964a1538c06a85a30a7552a6bc16c2c9d2a3c833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adaptation, Psychological</topic><topic>Adult</topic><topic>adults</topic><topic>Age of Onset</topic><topic>Child</topic><topic>Child Abuse - psychology</topic><topic>Child, Preschool</topic><topic>childhood</topic><topic>Childhood abuse</topic><topic>cohort studies</topic><topic>confidence interval</topic><topic>experimental design</topic><topic>gender</topic><topic>Humans</topic><topic>inflammation</topic><topic>life events</topic><topic>Mental Health</topic><topic>meta-analysis</topic><topic>obesity</topic><topic>Obesity - etiology</topic><topic>Obesity - psychology</topic><topic>observational studies</topic><topic>Observational Studies as Topic</topic><topic>Odds Ratio</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Substance-Related Disorders - etiology</topic><topic>Substance-Related Disorders - psychology</topic><topic>systematic review</topic><topic>Time Factors</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hemmingsson, E</creatorcontrib><creatorcontrib>Johansson, K</creatorcontrib><creatorcontrib>Reynisdottir, S</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Physical Education Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Gymnastik- och idrottshögskolan</collection><jtitle>Obesity reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hemmingsson, E</au><au>Johansson, K</au><au>Reynisdottir, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of childhood abuse on adult obesity: a systematic review and meta‐analysis</atitle><jtitle>Obesity reviews</jtitle><addtitle>Obes Rev</addtitle><date>2014-11</date><risdate>2014</risdate><volume>15</volume><issue>11</issue><spage>882</spage><epage>893</epage><pages>882-893</pages><issn>1467-7881</issn><issn>1467-789X</issn><eissn>1467-789X</eissn><abstract>Controversy exists surrounding the role of childhood abuse in obesity development. This is a meta‐analysis of observational studies on the role of childhood abuse in adult obesity. Systematic searches of PubMed, PsycInfo, Medline and CINAHL resulted in 23 cohort studies (4 prospective, 19 retrospective) with n = 112,708 participants, containing four abuse types (physical, emotional, sexual, general). Four studies reported dose–response effects. A random effects model was used to quantify effect sizes, meta‐regression/subgroup analysis for identifying potential moderating variables and Egger's test for publication bias. Adults who reported childhood abuse were significantly more likely to be obese (odds ratio [OR]: 1.34, 95% confidence interval [CI]: 1.24–1.45, P < 0.001). All four types of abuse were significantly associated with adult obesity: physical (OR: 1.28, 95% CI: 1.13–1.46), emotional (OR: 1.36, 95% CI: 1.08–1.71), sexual (OR: 1.31, 95% CI: 1.13–1.53) and general abuse (OR: 1.45, 95% CI: 1.25–1.69). Severe abuse (OR: 1.50, 95% CI: 1.27–1.77) was significantly more associated with adult obesity (P = 0.043) compared with light/moderate abuse (OR: 1.13, 95% CI: 0.91–1.41). We found no significant effects of study design (prospective vs. retrospective, P = 0.07), age (P = 0.96) or gender (P = 0.92). Publication bias was evident (Egger's test P = 0.007), but effect sizes remained statistically significant in sensitivity analyses. Childhood abuse was clearly associated with being obese as an adult, including a positive dose–response association. This suggests that adverse life experiences during childhood plays a major role in obesity development, potentially by inducing mental and emotional perturbations, maladaptive coping responses, stress, inflammation and metabolic disturbances.</abstract><cop>England</cop><pub>Blackwell Pub</pub><pmid>25123205</pmid><doi>10.1111/obr.12216</doi><tpages>12</tpages></addata></record> |
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| subjects | Adaptation, Psychological Adult adults Age of Onset Child Child Abuse - psychology Child, Preschool childhood Childhood abuse cohort studies confidence interval experimental design gender Humans inflammation life events Mental Health meta-analysis obesity Obesity - etiology Obesity - psychology observational studies Observational Studies as Topic Odds Ratio Prospective Studies Retrospective Studies Risk Factors Substance-Related Disorders - etiology Substance-Related Disorders - psychology systematic review Time Factors Weight Gain |
| title | Effects of childhood abuse on adult obesity: a systematic review and meta‐analysis |
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