Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA

ObjectivesSystemic lupus erythematosus (SLE; OMIM 152700) is characterised by the production of antibodies to nuclear antigens. We previously identified variants in complement receptor 2 (CR2/CD21) that were associated with decreased risk of SLE. This study aimed to identify the causal variant for t...

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Veröffentlicht in:	Annals of the rheumatic diseases 2016-01, Vol.75 (1), p.242-252
Hauptverfasser:	Zhao, Jian, Giles, Brendan M, Taylor, Rhonda L, Yette, Gabriel A, Lough, Kara M, Ng, Han Leng, Abraham, Lawrence J, Wu, Hui, Kelly, Jennifer A, Glenn, Stuart B, Adler, Adam J, Williams, Adrienne H, Comeau, Mary E, Ziegler, Julie T, Marion, Miranda, Alarcón-Riquelme, Marta E, Alarcón, Graciela S, Anaya, Juan-Manuel, Bae, Sang-Cheol, Kim, Dam, Lee, Hye-Soon, Criswell, Lindsey A, Freedman, Barry I, Gilkeson, Gary S, Guthridge, Joel M, Jacob, Chaim O, James, Judith A, Kamen, Diane L, Merrill, Joan T, Sivils, Kathy Moser, Niewold, Timothy B, Petri, Michelle A, Ramsey-Goldman, Rosalind, Reveille, John D, Scofield, R Hal, Stevens, Anne M, Vilá, Luis M, Vyse, Timothy J, Kaufman, Kenneth M, Harley, John B, Langefeld, Carl D, Gaffney, Patrick M, Brown, Elizabeth E, Edberg, Jeffrey C, Kimberly, Robert P, Ulgiati, Daniela, Tsao, Betty P, Boackle, Susan A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies, Antinuclear - blood Antigens Autoimmune diseases B-Lymphocyte Subsets - immunology Basic and Translational Research Case-Control Studies Cloning DNA - immunology Flow cytometry Genealogy Genetic Predisposition to Disease Genetic Variation Genotype Genotype & phenotype Haplotypes Humans Laboratories Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Middle Aged Phenotype Polymorphism, Single Nucleotide Receptors, Complement 3b - biosynthesis Receptors, Complement 3d - genetics Risk Assessment - methods Transcription Factors - metabolism Young Adult
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