Enzymatic 'stripping' and degradation of PEGylated carbon nanotubes
Single-walled carbon nanotubes (SWCNTs) coated or functionalized with PEG chains of different molecular weight were assessed for their propensity to undergo biodegradation under in vitro conditions using recombinant myeloperoxidase (MPO) or ex vivo using freshly isolated primary human neutrophils. O...
Gespeichert in:
| Veröffentlicht in: | Nanoscale 2014-01, Vol.6 (24), p.14686-14690 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 14690 |
|---|---|
| container_issue | 24 |
| container_start_page | 14686 |
| container_title | Nanoscale |
| container_volume | 6 |
| creator | Bhattacharya, Kunal Sacchetti, Cristiano El-Sayed, Ramy Fornara, Andrea Kotchey, Gregg P Gaugler, James A Star, Alexander Bottini, Massimo Fadeel, Bengt |
| description | Single-walled carbon nanotubes (SWCNTs) coated or functionalized with PEG chains of different molecular weight were assessed for their propensity to undergo biodegradation under in vitro conditions using recombinant myeloperoxidase (MPO) or ex vivo using freshly isolated primary human neutrophils. Our findings suggest that under natural conditions, a combined process of 'stripping' (i.e., defunctionalization) and biodegradation of PEG-SWCNTs might occur and that PEG-SWCNTs are a promising--and degradable--nanomedicine vector. |
| doi_str_mv | 10.1039/c4nr03604b |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_517818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1651427897</sourcerecordid><originalsourceid>FETCH-LOGICAL-c500t-fd23e1d5b0e56cb88f657137f73c75151114a28d634e6407cb0512bee9145b73</originalsourceid><addsrcrecordid>eNp1kc1Kw0AYRQdRbK1ufADJriJEZzJ_ybLGWoWiIsXtMH8p0XQSZxKkPr3R1rpy9V3udzibC8ApgpcI4uxKE-chZpCoPTBMIIExxjzZ32VGBuAohFcIWYYZPgSDhGLOecaHIJ-6z_VKtqWOxqH1ZdOUbjmOpDORsUsvTf-qXVQX0dN0tq5ka02kpVd956Sr207ZcAwOClkFe7K9I7C4nS7yu3j-OLvPJ_NYUwjbuDAJtshQBS1lWqVpwShHmBcca04RRQgRmaSGYWIZgVwrSFGirM0QoYrjEYg32vBhm06Jxpcr6deilqXYVm99soIinqK05y_-5W_Kl4mo_VL4UjBOsh4-38CNr987G1qxKoO2VSWdrbsgEKOIJDzN-J9X-zoEb4udGUHxPYjIycPzzyDXPXy29XZqZc0O_V0AfwH9yYVw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1651427897</pqid></control><display><type>article</type><title>Enzymatic 'stripping' and degradation of PEGylated carbon nanotubes</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Bhattacharya, Kunal ; Sacchetti, Cristiano ; El-Sayed, Ramy ; Fornara, Andrea ; Kotchey, Gregg P ; Gaugler, James A ; Star, Alexander ; Bottini, Massimo ; Fadeel, Bengt</creator><creatorcontrib>Bhattacharya, Kunal ; Sacchetti, Cristiano ; El-Sayed, Ramy ; Fornara, Andrea ; Kotchey, Gregg P ; Gaugler, James A ; Star, Alexander ; Bottini, Massimo ; Fadeel, Bengt</creatorcontrib><description>Single-walled carbon nanotubes (SWCNTs) coated or functionalized with PEG chains of different molecular weight were assessed for their propensity to undergo biodegradation under in vitro conditions using recombinant myeloperoxidase (MPO) or ex vivo using freshly isolated primary human neutrophils. Our findings suggest that under natural conditions, a combined process of 'stripping' (i.e., defunctionalization) and biodegradation of PEG-SWCNTs might occur and that PEG-SWCNTs are a promising--and degradable--nanomedicine vector.</description><identifier>ISSN: 2040-3364</identifier><identifier>ISSN: 2040-3372</identifier><identifier>EISSN: 2040-3372</identifier><identifier>DOI: 10.1039/c4nr03604b</identifier><identifier>PMID: 25377797</identifier><language>eng</language><publisher>England</publisher><subject>Biodegradation ; Cells, Cultured ; Coated Materials, Biocompatible - chemical synthesis ; Degradation ; Drug Design ; Drug Implants - chemistry ; Humans ; Mathematical analysis ; Molecular Weight ; Nanocapsules - chemistry ; Nanocapsules - ultrastructure ; Nanostructure ; Nanotubes, Carbon - chemistry ; Nanotubes, Carbon - ultrastructure ; Neutrophils - enzymology ; Particle Size ; Peroxidase - chemistry ; Polyethylene Glycols - chemistry ; Recombinant ; Single wall carbon nanotubes ; Stripping ; Substrate Specificity ; Vectors (mathematics)</subject><ispartof>Nanoscale, 2014-01, Vol.6 (24), p.14686-14690</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-fd23e1d5b0e56cb88f657137f73c75151114a28d634e6407cb0512bee9145b73</citedby><cites>FETCH-LOGICAL-c500t-fd23e1d5b0e56cb88f657137f73c75151114a28d634e6407cb0512bee9145b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25377797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:ri:diva-6749$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:130212112$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhattacharya, Kunal</creatorcontrib><creatorcontrib>Sacchetti, Cristiano</creatorcontrib><creatorcontrib>El-Sayed, Ramy</creatorcontrib><creatorcontrib>Fornara, Andrea</creatorcontrib><creatorcontrib>Kotchey, Gregg P</creatorcontrib><creatorcontrib>Gaugler, James A</creatorcontrib><creatorcontrib>Star, Alexander</creatorcontrib><creatorcontrib>Bottini, Massimo</creatorcontrib><creatorcontrib>Fadeel, Bengt</creatorcontrib><title>Enzymatic 'stripping' and degradation of PEGylated carbon nanotubes</title><title>Nanoscale</title><addtitle>Nanoscale</addtitle><description>Single-walled carbon nanotubes (SWCNTs) coated or functionalized with PEG chains of different molecular weight were assessed for their propensity to undergo biodegradation under in vitro conditions using recombinant myeloperoxidase (MPO) or ex vivo using freshly isolated primary human neutrophils. Our findings suggest that under natural conditions, a combined process of 'stripping' (i.e., defunctionalization) and biodegradation of PEG-SWCNTs might occur and that PEG-SWCNTs are a promising--and degradable--nanomedicine vector.</description><subject>Biodegradation</subject><subject>Cells, Cultured</subject><subject>Coated Materials, Biocompatible - chemical synthesis</subject><subject>Degradation</subject><subject>Drug Design</subject><subject>Drug Implants - chemistry</subject><subject>Humans</subject><subject>Mathematical analysis</subject><subject>Molecular Weight</subject><subject>Nanocapsules - chemistry</subject><subject>Nanocapsules - ultrastructure</subject><subject>Nanostructure</subject><subject>Nanotubes, Carbon - chemistry</subject><subject>Nanotubes, Carbon - ultrastructure</subject><subject>Neutrophils - enzymology</subject><subject>Particle Size</subject><subject>Peroxidase - chemistry</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Recombinant</subject><subject>Single wall carbon nanotubes</subject><subject>Stripping</subject><subject>Substrate Specificity</subject><subject>Vectors (mathematics)</subject><issn>2040-3364</issn><issn>2040-3372</issn><issn>2040-3372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1Kw0AYRQdRbK1ufADJriJEZzJ_ybLGWoWiIsXtMH8p0XQSZxKkPr3R1rpy9V3udzibC8ApgpcI4uxKE-chZpCoPTBMIIExxjzZ32VGBuAohFcIWYYZPgSDhGLOecaHIJ-6z_VKtqWOxqH1ZdOUbjmOpDORsUsvTf-qXVQX0dN0tq5ka02kpVd956Sr207ZcAwOClkFe7K9I7C4nS7yu3j-OLvPJ_NYUwjbuDAJtshQBS1lWqVpwShHmBcca04RRQgRmaSGYWIZgVwrSFGirM0QoYrjEYg32vBhm06Jxpcr6deilqXYVm99soIinqK05y_-5W_Kl4mo_VL4UjBOsh4-38CNr987G1qxKoO2VSWdrbsgEKOIJDzN-J9X-zoEb4udGUHxPYjIycPzzyDXPXy29XZqZc0O_V0AfwH9yYVw</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Bhattacharya, Kunal</creator><creator>Sacchetti, Cristiano</creator><creator>El-Sayed, Ramy</creator><creator>Fornara, Andrea</creator><creator>Kotchey, Gregg P</creator><creator>Gaugler, James A</creator><creator>Star, Alexander</creator><creator>Bottini, Massimo</creator><creator>Fadeel, Bengt</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope><scope>L7M</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20140101</creationdate><title>Enzymatic 'stripping' and degradation of PEGylated carbon nanotubes</title><author>Bhattacharya, Kunal ; Sacchetti, Cristiano ; El-Sayed, Ramy ; Fornara, Andrea ; Kotchey, Gregg P ; Gaugler, James A ; Star, Alexander ; Bottini, Massimo ; Fadeel, Bengt</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-fd23e1d5b0e56cb88f657137f73c75151114a28d634e6407cb0512bee9145b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biodegradation</topic><topic>Cells, Cultured</topic><topic>Coated Materials, Biocompatible - chemical synthesis</topic><topic>Degradation</topic><topic>Drug Design</topic><topic>Drug Implants - chemistry</topic><topic>Humans</topic><topic>Mathematical analysis</topic><topic>Molecular Weight</topic><topic>Nanocapsules - chemistry</topic><topic>Nanocapsules - ultrastructure</topic><topic>Nanostructure</topic><topic>Nanotubes, Carbon - chemistry</topic><topic>Nanotubes, Carbon - ultrastructure</topic><topic>Neutrophils - enzymology</topic><topic>Particle Size</topic><topic>Peroxidase - chemistry</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Recombinant</topic><topic>Single wall carbon nanotubes</topic><topic>Stripping</topic><topic>Substrate Specificity</topic><topic>Vectors (mathematics)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhattacharya, Kunal</creatorcontrib><creatorcontrib>Sacchetti, Cristiano</creatorcontrib><creatorcontrib>El-Sayed, Ramy</creatorcontrib><creatorcontrib>Fornara, Andrea</creatorcontrib><creatorcontrib>Kotchey, Gregg P</creatorcontrib><creatorcontrib>Gaugler, James A</creatorcontrib><creatorcontrib>Star, Alexander</creatorcontrib><creatorcontrib>Bottini, Massimo</creatorcontrib><creatorcontrib>Fadeel, Bengt</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Nanoscale</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhattacharya, Kunal</au><au>Sacchetti, Cristiano</au><au>El-Sayed, Ramy</au><au>Fornara, Andrea</au><au>Kotchey, Gregg P</au><au>Gaugler, James A</au><au>Star, Alexander</au><au>Bottini, Massimo</au><au>Fadeel, Bengt</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enzymatic 'stripping' and degradation of PEGylated carbon nanotubes</atitle><jtitle>Nanoscale</jtitle><addtitle>Nanoscale</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>6</volume><issue>24</issue><spage>14686</spage><epage>14690</epage><pages>14686-14690</pages><issn>2040-3364</issn><issn>2040-3372</issn><eissn>2040-3372</eissn><abstract>Single-walled carbon nanotubes (SWCNTs) coated or functionalized with PEG chains of different molecular weight were assessed for their propensity to undergo biodegradation under in vitro conditions using recombinant myeloperoxidase (MPO) or ex vivo using freshly isolated primary human neutrophils. Our findings suggest that under natural conditions, a combined process of 'stripping' (i.e., defunctionalization) and biodegradation of PEG-SWCNTs might occur and that PEG-SWCNTs are a promising--and degradable--nanomedicine vector.</abstract><cop>England</cop><pmid>25377797</pmid><doi>10.1039/c4nr03604b</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2040-3364 |
| ispartof | Nanoscale, 2014-01, Vol.6 (24), p.14686-14690 |
| issn | 2040-3364 2040-3372 2040-3372 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_517818 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Biodegradation Cells, Cultured Coated Materials, Biocompatible - chemical synthesis Degradation Drug Design Drug Implants - chemistry Humans Mathematical analysis Molecular Weight Nanocapsules - chemistry Nanocapsules - ultrastructure Nanostructure Nanotubes, Carbon - chemistry Nanotubes, Carbon - ultrastructure Neutrophils - enzymology Particle Size Peroxidase - chemistry Polyethylene Glycols - chemistry Recombinant Single wall carbon nanotubes Stripping Substrate Specificity Vectors (mathematics) |
| title | Enzymatic 'stripping' and degradation of PEGylated carbon nanotubes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T17%3A45%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Enzymatic%20'stripping'%20and%20degradation%20of%20PEGylated%20carbon%20nanotubes&rft.jtitle=Nanoscale&rft.au=Bhattacharya,%20Kunal&rft.date=2014-01-01&rft.volume=6&rft.issue=24&rft.spage=14686&rft.epage=14690&rft.pages=14686-14690&rft.issn=2040-3364&rft.eissn=2040-3372&rft_id=info:doi/10.1039/c4nr03604b&rft_dat=%3Cproquest_swepu%3E1651427897%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1651427897&rft_id=info:pmid/25377797&rfr_iscdi=true |