Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome
Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets.Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene...
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| Veröffentlicht in: | The American journal of clinical nutrition 2015, Vol.101 (1), p.228-239 |
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| creator | Kolehmainen, Marjukka Ulven, Stine M Paananen, Jussi de Mello, Vanessa Schwab, Ursula Carlberg, Carsten Myhrstad, Mari Pihlajamäki, Jussi Dungner, Elisabeth Sjölin, Eva Gunnarsdottir, Ingibjörg Cloetens, Lieselotte Landin-Olsson, Mona Akesson, Björn Rosqvist, Fredrik Hukkanen, Janne Herzig, Karl-Heinz Dragsted, Lars O Savolainen, Markku J Brader, Lea Hermansen, Kjeld Risérus, Ulf Thorsdottir, Inga Poutanen, Kaisa S Uusitupa, Matti Arner, Peter Dahlman, Ingrid |
| description | Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets.Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects.Design: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration |
| doi_str_mv | 10.3945/ajcn.114.092783 |
| format | Article |
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The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration <10 mg/L at the beginning and the end of the intervention, and baseline body mass index (in kg/m2) <38. SAT biopsy specimens were obtained before and after the intervention and subjected to global transcriptome analysis with Gene 1.1 ST Arrays (Affymetrix).Results: Altogether, 128 genes were differentially expressed in SAT between the ND and CD (nominal P < 0.01; false discovery rate, 25%). These genes were overrepresented in pathways related to immune response (adjusted P = 0.0076), resulting mainly from slightly decreased expression in the ND and increased expression in the CD. Immune-related pathways included leukocyte trafficking and macrophage recruitment (e.g., interferon regulatory factor 1, CD97), adaptive immune response (interleukin32, interleukin 6 receptor), and reactive oxygen species (neutrophil cytosolic factor 1). Interestingly, the regulatory region of the 128 genes was overrepresented for binding sites for the nuclear transcription factor κB.Conclusion: A healthy Nordic diet reduces inflammatory gene expression in SAT compared with a control diet independently of body weight change in individuals with features of the metabolic syndrome. The study was registered at clinicaltrials.gov as NCT00992641.</description><identifier>ISSN: 0002-9165</identifier><identifier>ISSN: 1938-3207</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.114.092783</identifier><identifier>PMID: 25527767</identifier><language>eng</language><publisher>United States: American Society for Clinical Nutrition</publisher><subject>Adaptive Immunity ; adipose tissue ; adults ; binding sites ; Biochemistry ; Biopsy ; Body Mass Index ; body weight ; C-reactive protein ; C-Reactive Protein - analysis ; clinical nutrition ; cohort studies ; Diet ; Diet - ethnology ; Down-Regulation ; Fatty acids ; Female ; Finland ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation ; genes ; Health Promotion ; Health Sciences ; Humans ; Hälsovetenskap ; immune response ; inflammation ; Inflammatory diseases ; interferon regulatory factors ; interleukin-6 ; Leukocytes ; macrophages ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - diet therapy ; Metabolic Syndrome - immunology ; Metabolic Syndrome - metabolism ; Middle Aged ; neutrophils ; Nutrition and Dietetics ; Nutrition Policy ; nutritional intervention ; Näringslära ; Obesity - complications ; Oligonucleotide Array Sequence Analysis ; reactive oxygen species ; Subcutaneous Fat, Abdominal - immunology ; Subcutaneous Fat, Abdominal - metabolism ; Subcutaneous Fat, Abdominal - pathology ; Sweden ; transcriptomics</subject><ispartof>The American journal of clinical nutrition, 2015, Vol.101 (1), p.228-239</ispartof><rights>2015 American Society for Nutrition.</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Jan 1, 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-9741813959c1e9d0935d73bfb57c4d2ace6f2038e5121b32acf87974a7d93303</citedby><cites>FETCH-LOGICAL-c567t-9741813959c1e9d0935d73bfb57c4d2ace6f2038e5121b32acf87974a7d93303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25527767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-240038$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/4905872$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:130374601$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolehmainen, Marjukka</creatorcontrib><creatorcontrib>Ulven, Stine M</creatorcontrib><creatorcontrib>Paananen, Jussi</creatorcontrib><creatorcontrib>de Mello, Vanessa</creatorcontrib><creatorcontrib>Schwab, Ursula</creatorcontrib><creatorcontrib>Carlberg, Carsten</creatorcontrib><creatorcontrib>Myhrstad, Mari</creatorcontrib><creatorcontrib>Pihlajamäki, Jussi</creatorcontrib><creatorcontrib>Dungner, Elisabeth</creatorcontrib><creatorcontrib>Sjölin, Eva</creatorcontrib><creatorcontrib>Gunnarsdottir, Ingibjörg</creatorcontrib><creatorcontrib>Cloetens, Lieselotte</creatorcontrib><creatorcontrib>Landin-Olsson, Mona</creatorcontrib><creatorcontrib>Akesson, Björn</creatorcontrib><creatorcontrib>Rosqvist, Fredrik</creatorcontrib><creatorcontrib>Hukkanen, Janne</creatorcontrib><creatorcontrib>Herzig, Karl-Heinz</creatorcontrib><creatorcontrib>Dragsted, Lars O</creatorcontrib><creatorcontrib>Savolainen, Markku J</creatorcontrib><creatorcontrib>Brader, Lea</creatorcontrib><creatorcontrib>Hermansen, Kjeld</creatorcontrib><creatorcontrib>Risérus, Ulf</creatorcontrib><creatorcontrib>Thorsdottir, Inga</creatorcontrib><creatorcontrib>Poutanen, Kaisa S</creatorcontrib><creatorcontrib>Uusitupa, Matti</creatorcontrib><creatorcontrib>Arner, Peter</creatorcontrib><creatorcontrib>Dahlman, Ingrid</creatorcontrib><title>Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets.Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects.Design: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration <10 mg/L at the beginning and the end of the intervention, and baseline body mass index (in kg/m2) <38. SAT biopsy specimens were obtained before and after the intervention and subjected to global transcriptome analysis with Gene 1.1 ST Arrays (Affymetrix).Results: Altogether, 128 genes were differentially expressed in SAT between the ND and CD (nominal P < 0.01; false discovery rate, 25%). These genes were overrepresented in pathways related to immune response (adjusted P = 0.0076), resulting mainly from slightly decreased expression in the ND and increased expression in the CD. Immune-related pathways included leukocyte trafficking and macrophage recruitment (e.g., interferon regulatory factor 1, CD97), adaptive immune response (interleukin32, interleukin 6 receptor), and reactive oxygen species (neutrophil cytosolic factor 1). Interestingly, the regulatory region of the 128 genes was overrepresented for binding sites for the nuclear transcription factor κB.Conclusion: A healthy Nordic diet reduces inflammatory gene expression in SAT compared with a control diet independently of body weight change in individuals with features of the metabolic syndrome. The study was registered at clinicaltrials.gov as NCT00992641.</description><subject>Adaptive Immunity</subject><subject>adipose tissue</subject><subject>adults</subject><subject>binding sites</subject><subject>Biochemistry</subject><subject>Biopsy</subject><subject>Body Mass Index</subject><subject>body weight</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>clinical nutrition</subject><subject>cohort studies</subject><subject>Diet</subject><subject>Diet - ethnology</subject><subject>Down-Regulation</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Finland</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation</subject><subject>genes</subject><subject>Health Promotion</subject><subject>Health Sciences</subject><subject>Humans</subject><subject>Hälsovetenskap</subject><subject>immune response</subject><subject>inflammation</subject><subject>Inflammatory diseases</subject><subject>interferon regulatory factors</subject><subject>interleukin-6</subject><subject>Leukocytes</subject><subject>macrophages</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - diet therapy</subject><subject>Metabolic Syndrome - immunology</subject><subject>Metabolic Syndrome - metabolism</subject><subject>Middle Aged</subject><subject>neutrophils</subject><subject>Nutrition and Dietetics</subject><subject>Nutrition Policy</subject><subject>nutritional intervention</subject><subject>Näringslära</subject><subject>Obesity - complications</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>reactive oxygen species</subject><subject>Subcutaneous Fat, Abdominal - immunology</subject><subject>Subcutaneous Fat, Abdominal - metabolism</subject><subject>Subcutaneous Fat, Abdominal - pathology</subject><subject>Sweden</subject><subject>transcriptomics</subject><issn>0002-9165</issn><issn>1938-3207</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqNkk1v1DAQhiMEokvhzA0iceHAtv6M42NVPoq0ggOFq-XEk10vSbyN4132H_EzmShLD0iVkDyyPXrm9dh-s-wlJRdcC3lpt3V_Qam4IJqpkj_KFlTzcskZUY-zBSGELTUt5Fn2LMYtIZSJsnianTEpmVKFWmS_b8C24-aYfwmD83XuPIy5C4d-gHVq7QgxHzeQw6_dADH60OehydfQY973-9DuweECR9ParrPjROA-pqpOo-0hpJhb53chQj76GBPMuPN775JtY37w4yZvwI4JT5jUp_M6GG0VWmwoHns3hA6eZ08axOHFaT7Pbj9-uL2-Wa6-fvp8fbVa1rJQ41IrQUvKtdQ1Be2I5tIpXjWVVLVwzNZQNIzwEiRltOKYaEqFRVY5zTnh59lylo0H2KXK7Abf2eFogvXmlPqJKzCSFopO_OpBvk07jApjKhDEKkmdNqQmpRGSFUZTZo1ztXPa4TcJiXLvHpR7739cmTCsTUqGCYKXQPztjO-GcJcgjqbzsYa2nV_e0EILXRLG_gdFQ2l0yIS--QfdhjT0-OpICSFKRjVF6nKm6iHEOEBz3ywlZjKnmcxp0JxmNidWvDrppqoDd8__dSMCr2egscHY9eCj-f6NESrRuZISJfkfdznsdQ</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Kolehmainen, Marjukka</creator><creator>Ulven, Stine M</creator><creator>Paananen, Jussi</creator><creator>de Mello, Vanessa</creator><creator>Schwab, Ursula</creator><creator>Carlberg, Carsten</creator><creator>Myhrstad, Mari</creator><creator>Pihlajamäki, Jussi</creator><creator>Dungner, Elisabeth</creator><creator>Sjölin, Eva</creator><creator>Gunnarsdottir, Ingibjörg</creator><creator>Cloetens, Lieselotte</creator><creator>Landin-Olsson, Mona</creator><creator>Akesson, Björn</creator><creator>Rosqvist, Fredrik</creator><creator>Hukkanen, Janne</creator><creator>Herzig, Karl-Heinz</creator><creator>Dragsted, Lars O</creator><creator>Savolainen, Markku J</creator><creator>Brader, Lea</creator><creator>Hermansen, Kjeld</creator><creator>Risérus, Ulf</creator><creator>Thorsdottir, Inga</creator><creator>Poutanen, Kaisa S</creator><creator>Uusitupa, Matti</creator><creator>Arner, Peter</creator><creator>Dahlman, Ingrid</creator><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>RC3</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope><scope>D95</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>2015</creationdate><title>Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome</title><author>Kolehmainen, Marjukka ; Ulven, Stine M ; Paananen, Jussi ; de Mello, Vanessa ; Schwab, Ursula ; Carlberg, Carsten ; Myhrstad, Mari ; Pihlajamäki, Jussi ; Dungner, Elisabeth ; Sjölin, Eva ; Gunnarsdottir, Ingibjörg ; Cloetens, Lieselotte ; Landin-Olsson, Mona ; Akesson, Björn ; Rosqvist, Fredrik ; Hukkanen, Janne ; Herzig, Karl-Heinz ; Dragsted, Lars O ; Savolainen, Markku J ; Brader, Lea ; Hermansen, Kjeld ; Risérus, Ulf ; Thorsdottir, Inga ; Poutanen, Kaisa S ; Uusitupa, Matti ; Arner, Peter ; Dahlman, Ingrid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-9741813959c1e9d0935d73bfb57c4d2ace6f2038e5121b32acf87974a7d93303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adaptive Immunity</topic><topic>adipose tissue</topic><topic>adults</topic><topic>binding sites</topic><topic>Biochemistry</topic><topic>Biopsy</topic><topic>Body Mass Index</topic><topic>body weight</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - 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complications</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>reactive oxygen species</topic><topic>Subcutaneous Fat, Abdominal - immunology</topic><topic>Subcutaneous Fat, Abdominal - metabolism</topic><topic>Subcutaneous Fat, Abdominal - pathology</topic><topic>Sweden</topic><topic>transcriptomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kolehmainen, Marjukka</creatorcontrib><creatorcontrib>Ulven, Stine M</creatorcontrib><creatorcontrib>Paananen, Jussi</creatorcontrib><creatorcontrib>de Mello, Vanessa</creatorcontrib><creatorcontrib>Schwab, Ursula</creatorcontrib><creatorcontrib>Carlberg, Carsten</creatorcontrib><creatorcontrib>Myhrstad, Mari</creatorcontrib><creatorcontrib>Pihlajamäki, Jussi</creatorcontrib><creatorcontrib>Dungner, Elisabeth</creatorcontrib><creatorcontrib>Sjölin, Eva</creatorcontrib><creatorcontrib>Gunnarsdottir, Ingibjörg</creatorcontrib><creatorcontrib>Cloetens, Lieselotte</creatorcontrib><creatorcontrib>Landin-Olsson, Mona</creatorcontrib><creatorcontrib>Akesson, Björn</creatorcontrib><creatorcontrib>Rosqvist, Fredrik</creatorcontrib><creatorcontrib>Hukkanen, Janne</creatorcontrib><creatorcontrib>Herzig, Karl-Heinz</creatorcontrib><creatorcontrib>Dragsted, Lars O</creatorcontrib><creatorcontrib>Savolainen, Markku J</creatorcontrib><creatorcontrib>Brader, Lea</creatorcontrib><creatorcontrib>Hermansen, Kjeld</creatorcontrib><creatorcontrib>Risérus, Ulf</creatorcontrib><creatorcontrib>Thorsdottir, Inga</creatorcontrib><creatorcontrib>Poutanen, Kaisa S</creatorcontrib><creatorcontrib>Uusitupa, Matti</creatorcontrib><creatorcontrib>Arner, Peter</creatorcontrib><creatorcontrib>Dahlman, Ingrid</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Genetics Abstracts</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Lunds universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kolehmainen, Marjukka</au><au>Ulven, Stine M</au><au>Paananen, Jussi</au><au>de Mello, Vanessa</au><au>Schwab, Ursula</au><au>Carlberg, Carsten</au><au>Myhrstad, Mari</au><au>Pihlajamäki, Jussi</au><au>Dungner, Elisabeth</au><au>Sjölin, Eva</au><au>Gunnarsdottir, Ingibjörg</au><au>Cloetens, Lieselotte</au><au>Landin-Olsson, Mona</au><au>Akesson, Björn</au><au>Rosqvist, Fredrik</au><au>Hukkanen, Janne</au><au>Herzig, Karl-Heinz</au><au>Dragsted, Lars O</au><au>Savolainen, Markku J</au><au>Brader, Lea</au><au>Hermansen, Kjeld</au><au>Risérus, Ulf</au><au>Thorsdottir, Inga</au><au>Poutanen, Kaisa S</au><au>Uusitupa, Matti</au><au>Arner, Peter</au><au>Dahlman, Ingrid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2015</date><risdate>2015</risdate><volume>101</volume><issue>1</issue><spage>228</spage><epage>239</epage><pages>228-239</pages><issn>0002-9165</issn><issn>1938-3207</issn><eissn>1938-3207</eissn><abstract>Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets.Objective: The objective was to explore whether the ND has an impact on gene expression in abdominal subcutaneous adipose tissue (SAT) and whether changes in gene expression are associated with clinical and biochemical effects.Design: Obese adults with features of the metabolic syndrome underwent an 18- to 24-wk randomized intervention study comparing the ND with the control diet (CD) (the SYSDIET study, carried out within Nordic Centre of Excellence of the Systems Biology in Controlled Dietary Interventions and Cohort Studies). The present study included participants from 3 Nordic SYSDIET centers [Kuopio (n = 20), Lund (n = 18), and Oulu (n = 18)] with a maximum weight change of ±4 kg, highly sensitive C-reactive protein concentration <10 mg/L at the beginning and the end of the intervention, and baseline body mass index (in kg/m2) <38. SAT biopsy specimens were obtained before and after the intervention and subjected to global transcriptome analysis with Gene 1.1 ST Arrays (Affymetrix).Results: Altogether, 128 genes were differentially expressed in SAT between the ND and CD (nominal P < 0.01; false discovery rate, 25%). These genes were overrepresented in pathways related to immune response (adjusted P = 0.0076), resulting mainly from slightly decreased expression in the ND and increased expression in the CD. Immune-related pathways included leukocyte trafficking and macrophage recruitment (e.g., interferon regulatory factor 1, CD97), adaptive immune response (interleukin32, interleukin 6 receptor), and reactive oxygen species (neutrophil cytosolic factor 1). Interestingly, the regulatory region of the 128 genes was overrepresented for binding sites for the nuclear transcription factor κB.Conclusion: A healthy Nordic diet reduces inflammatory gene expression in SAT compared with a control diet independently of body weight change in individuals with features of the metabolic syndrome. The study was registered at clinicaltrials.gov as NCT00992641.</abstract><cop>United States</cop><pub>American Society for Clinical Nutrition</pub><pmid>25527767</pmid><doi>10.3945/ajcn.114.092783</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 2015, Vol.101 (1), p.228-239 |
| issn | 0002-9165 1938-3207 1938-3207 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_516710 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Adaptive Immunity adipose tissue adults binding sites Biochemistry Biopsy Body Mass Index body weight C-reactive protein C-Reactive Protein - analysis clinical nutrition cohort studies Diet Diet - ethnology Down-Regulation Fatty acids Female Finland Gene expression Gene Expression Profiling Gene Expression Regulation genes Health Promotion Health Sciences Humans Hälsovetenskap immune response inflammation Inflammatory diseases interferon regulatory factors interleukin-6 Leukocytes macrophages Male Medical and Health Sciences Medicin och hälsovetenskap Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - diet therapy Metabolic Syndrome - immunology Metabolic Syndrome - metabolism Middle Aged neutrophils Nutrition and Dietetics Nutrition Policy nutritional intervention Näringslära Obesity - complications Oligonucleotide Array Sequence Analysis reactive oxygen species Subcutaneous Fat, Abdominal - immunology Subcutaneous Fat, Abdominal - metabolism Subcutaneous Fat, Abdominal - pathology Sweden transcriptomics |
| title | Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome |
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