Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations

An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset #2 (IGHV3-21/IGLV3-21), in particular, determines outcome for IGHV3-21-utilizing cases. We reappraised this issue in 8...

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Veröffentlicht in:	Blood 2015-01, Vol.125 (5), p.856-859
Hauptverfasser:	Baliakas, Panagiotis, Agathangelidis, Andreas, Hadzidimitriou, Anastasia, Sutton, Lesley-Ann, Minga, Eva, Tsanousa, Athina, Scarfò, Lydia, Davis, Zadie, Yan, Xiao-Jie, Shanafelt, Tait, Plevova, Karla, Sandberg, Yorick, Vojdeman, Fie Juhl, Boudjogra, Myriam, Tzenou, Tatiana, Chatzouli, Maria, Chu, Charles C., Veronese, Silvio, Gardiner, Anne, Mansouri, Larry, Smedby, Karin E., Pedersen, Lone Bredo, Moreno, Denis, Van Lom, Kirsten, Giudicelli, Véronique, Francova, Hana Skuhrova, Nguyen-Khac, Florence, Panagiotidis, Panagiotis, Juliusson, Gunnar, Angelis, Lefteris, Anagnostopoulos, Achilles, Lefranc, Marie-Paule, Facco, Monica, Trentin, Livio, Catherwood, Mark, Montillo, Marco, Geisler, Christian H., Langerak, Anton W., Pospisilova, Sarka, Chiorazzi, Nicholas, Oscier, David, Jelinek, Diane F., Darzentas, Nikos, Belessi, Chrysoula, Davi, Frederic, Ghia, Paolo, Rosenquist, Richard, Stamatopoulos, Kostas
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents Antineoplastic Agents - therapeutic use B-Lymphocytes B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - pathology Brief Report Clinical Medicine Female Gene Expression Regulation, Leukemic Gene Rearrangement, B-Lymphocyte, Heavy Chain Gene Rearrangement, B-Lymphocyte, Heavy Chain - immunology Genetic Heterogeneity Genetics Hematologi Hematology Humans Immunoglobulin Heavy Chains Immunoglobulin Heavy Chains - genetics Klinisk medicin Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - mortality Life Sciences Lymphoid Neoplasia Male Medical and Health Sciences Medicin och hälsovetenskap Middle Aged Prognosis Somatic Hypermutation, Immunoglobulin Survival Analysis Time-to-Treatment Treatment Outcome
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