Infertility and incident endometrial cancer risk: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)
Background: Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes. Methods: We conducted a pooled analysis of 8153 case...
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| Veröffentlicht in: | British journal of cancer 2015-03, Vol.112 (5), p.925-933 |
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| creator | Yang, H P Cook, L S Weiderpass, E Adami, H-O Anderson, K E Cai, H Cerhan, J R Clendenen, T V Felix, A S Friedenreich, C M Garcia-Closas, M Goodman, M T Liang, X Lissowska, J Lu, L Magliocco, A M McCann, S E Moysich, K B Olson, S H Petruzella, S Pike, M C Polidoro, S Ricceri, F Risch, H A Sacerdote, C Setiawan, V W Shu, X O Spurdle, A B Trabert, B Webb, P M Wentzensen, N Xiang, Y-B Xu, Y Yu, H Zeleniuch-Jacquotte, A Brinton, L A |
| description | Background:
Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes.
Methods:
We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided self-reported infertility and its causes, except for one study that relied on data from national registries. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).
Results:
Nulliparous women had an elevated endometrial cancer risk compared with parous women, even after adjusting for infertility (OR=1.76; 95% CI: 1.59–1.94). Women who reported infertility had an increased risk compared with those without infertility concerns, even after adjusting for nulliparity (OR=1.22; 95% CI: 1.13–1.33). Among women who reported infertility, none of the individual infertility causes were substantially related to endometrial cancer.
Conclusions:
Based on mainly self-reported infertility data that used study-specific definitions of infertility, nulliparity and infertility appeared to independently contribute to endometrial cancer risk. Understanding residual endometrial cancer risk related to infertility, its causes and its treatments may benefit from large studies involving detailed data on various infertility parameters. |
| doi_str_mv | 10.1038/bjc.2015.24 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_515596</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3613102801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c677t-d1c1b21f5520669e6d34a04c34a2e321efd86ceb67c520a6690fb0f032f010463</originalsourceid><addsrcrecordid>eNqNkk1vEzEQhlcIRNPCiTtY4lIEG8b2ej84VEJRgUqVuMDZcryzqdNdO7U3oBz558wqadWiHrj4a555ZzwzWfaKw5yDrD8u13YugKu5KJ5kM66kyHktqqfZDACqHBoBR9lxSmu6NlBXz7Mjocq6rmQ9y_5c-A7j6Ho37pjxLXPeuhb9yNC3YcAxOtMza7zFyKJL15-YYZsQemwJN_0uucS6GAY2XiHDDfkOLvRhtWOhe0zDBp8CBdwO7PRcLMS7F9mzzvQJXx72k-znl_Mfi2_55fevF4vPl7ktq2rMW275UvBOKQFl2WDZysJAYWkVKAXHrq1Li8uyskQYQqBbQgdSdMChKOVJlu9102_cbJd6E91g4k4H4_Th6ZpOqBVXqpn4sz1PlgFbSzWJpn_g9tDi3ZVehV-6KJRsVEECb_YCluo2Oq99iEZzAFlpUTSFJOL0ECKGmy2mUQ8uWex74zFsk-ZlWQsFigT_A6VGK1FNqm__QddhG6lXe0pWNcAk-P42u5BSxO7uZxz0NFea5kpPc0XJEv36fjHu2NtBIuDDobpk8iuM94I-ovcXHaTXXQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1660378005</pqid></control><display><type>article</type><title>Infertility and incident endometrial cancer risk: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)</title><source>MEDLINE</source><source>NORA - Norwegian Open Research Archives</source><source>Nature Journals Online</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><source>SpringerLink Journals - AutoHoldings</source><creator>Yang, H P ; Cook, L S ; Weiderpass, E ; Adami, H-O ; Anderson, K E ; Cai, H ; Cerhan, J R ; Clendenen, T V ; Felix, A S ; Friedenreich, C M ; Garcia-Closas, M ; Goodman, M T ; Liang, X ; Lissowska, J ; Lu, L ; Magliocco, A M ; McCann, S E ; Moysich, K B ; Olson, S H ; Petruzella, S ; Pike, M C ; Polidoro, S ; Ricceri, F ; Risch, H A ; Sacerdote, C ; Setiawan, V W ; Shu, X O ; Spurdle, A B ; Trabert, B ; Webb, P M ; Wentzensen, N ; Xiang, Y-B ; Xu, Y ; Yu, H ; Zeleniuch-Jacquotte, A ; Brinton, L A</creator><creatorcontrib>Yang, H P ; Cook, L S ; Weiderpass, E ; Adami, H-O ; Anderson, K E ; Cai, H ; Cerhan, J R ; Clendenen, T V ; Felix, A S ; Friedenreich, C M ; Garcia-Closas, M ; Goodman, M T ; Liang, X ; Lissowska, J ; Lu, L ; Magliocco, A M ; McCann, S E ; Moysich, K B ; Olson, S H ; Petruzella, S ; Pike, M C ; Polidoro, S ; Ricceri, F ; Risch, H A ; Sacerdote, C ; Setiawan, V W ; Shu, X O ; Spurdle, A B ; Trabert, B ; Webb, P M ; Wentzensen, N ; Xiang, Y-B ; Xu, Y ; Yu, H ; Zeleniuch-Jacquotte, A ; Brinton, L A</creatorcontrib><description>Background:
Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes.
Methods:
We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided self-reported infertility and its causes, except for one study that relied on data from national registries. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).
Results:
Nulliparous women had an elevated endometrial cancer risk compared with parous women, even after adjusting for infertility (OR=1.76; 95% CI: 1.59–1.94). Women who reported infertility had an increased risk compared with those without infertility concerns, even after adjusting for nulliparity (OR=1.22; 95% CI: 1.13–1.33). Among women who reported infertility, none of the individual infertility causes were substantially related to endometrial cancer.
Conclusions:
Based on mainly self-reported infertility data that used study-specific definitions of infertility, nulliparity and infertility appeared to independently contribute to endometrial cancer risk. Understanding residual endometrial cancer risk related to infertility, its causes and its treatments may benefit from large studies involving detailed data on various infertility parameters.</description><identifier>ISSN: 0007-0920</identifier><identifier>ISSN: 1532-1827</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2015.24</identifier><identifier>PMID: 25688738</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/2732/1577 ; 692/699/67/1517/1931 ; 692/699/67/2324 ; Adult ; Aged ; Aged, 80 and over ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cohort Studies ; Drug Resistance ; Endometrial Neoplasms - epidemiology ; Endometrial Neoplasms - etiology ; Epidemiology ; Female ; Humans ; Infertility, Female - epidemiology ; Logistic Models ; Middle Aged ; Molecular Medicine ; Oncology ; Parity ; Risk Factors ; Self Report</subject><ispartof>British journal of cancer, 2015-03, Vol.112 (5), p.925-933</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Mar 3, 2015</rights><rights>info:eu-repo/semantics/openAccess</rights><rights>Copyright © 2015 Cancer Research UK 2015 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c677t-d1c1b21f5520669e6d34a04c34a2e321efd86ceb67c520a6690fb0f032f010463</citedby><cites>FETCH-LOGICAL-c677t-d1c1b21f5520669e6d34a04c34a2e321efd86ceb67c520a6690fb0f032f010463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453954/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453954/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,881,26544,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25688738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:130898409$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, H P</creatorcontrib><creatorcontrib>Cook, L S</creatorcontrib><creatorcontrib>Weiderpass, E</creatorcontrib><creatorcontrib>Adami, H-O</creatorcontrib><creatorcontrib>Anderson, K E</creatorcontrib><creatorcontrib>Cai, H</creatorcontrib><creatorcontrib>Cerhan, J R</creatorcontrib><creatorcontrib>Clendenen, T V</creatorcontrib><creatorcontrib>Felix, A S</creatorcontrib><creatorcontrib>Friedenreich, C M</creatorcontrib><creatorcontrib>Garcia-Closas, M</creatorcontrib><creatorcontrib>Goodman, M T</creatorcontrib><creatorcontrib>Liang, X</creatorcontrib><creatorcontrib>Lissowska, J</creatorcontrib><creatorcontrib>Lu, L</creatorcontrib><creatorcontrib>Magliocco, A M</creatorcontrib><creatorcontrib>McCann, S E</creatorcontrib><creatorcontrib>Moysich, K B</creatorcontrib><creatorcontrib>Olson, S H</creatorcontrib><creatorcontrib>Petruzella, S</creatorcontrib><creatorcontrib>Pike, M C</creatorcontrib><creatorcontrib>Polidoro, S</creatorcontrib><creatorcontrib>Ricceri, F</creatorcontrib><creatorcontrib>Risch, H A</creatorcontrib><creatorcontrib>Sacerdote, C</creatorcontrib><creatorcontrib>Setiawan, V W</creatorcontrib><creatorcontrib>Shu, X O</creatorcontrib><creatorcontrib>Spurdle, A B</creatorcontrib><creatorcontrib>Trabert, B</creatorcontrib><creatorcontrib>Webb, P M</creatorcontrib><creatorcontrib>Wentzensen, N</creatorcontrib><creatorcontrib>Xiang, Y-B</creatorcontrib><creatorcontrib>Xu, Y</creatorcontrib><creatorcontrib>Yu, H</creatorcontrib><creatorcontrib>Zeleniuch-Jacquotte, A</creatorcontrib><creatorcontrib>Brinton, L A</creatorcontrib><title>Infertility and incident endometrial cancer risk: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes.
Methods:
We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided self-reported infertility and its causes, except for one study that relied on data from national registries. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).
Results:
Nulliparous women had an elevated endometrial cancer risk compared with parous women, even after adjusting for infertility (OR=1.76; 95% CI: 1.59–1.94). Women who reported infertility had an increased risk compared with those without infertility concerns, even after adjusting for nulliparity (OR=1.22; 95% CI: 1.13–1.33). Among women who reported infertility, none of the individual infertility causes were substantially related to endometrial cancer.
Conclusions:
Based on mainly self-reported infertility data that used study-specific definitions of infertility, nulliparity and infertility appeared to independently contribute to endometrial cancer risk. Understanding residual endometrial cancer risk related to infertility, its causes and its treatments may benefit from large studies involving detailed data on various infertility parameters.</description><subject>692/699/2732/1577</subject><subject>692/699/67/1517/1931</subject><subject>692/699/67/2324</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Cohort Studies</subject><subject>Drug Resistance</subject><subject>Endometrial Neoplasms - epidemiology</subject><subject>Endometrial Neoplasms - etiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Infertility, Female - epidemiology</subject><subject>Logistic Models</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Parity</subject><subject>Risk Factors</subject><subject>Self Report</subject><issn>0007-0920</issn><issn>1532-1827</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>3HK</sourceid><sourceid>D8T</sourceid><recordid>eNqNkk1vEzEQhlcIRNPCiTtY4lIEG8b2ej84VEJRgUqVuMDZcryzqdNdO7U3oBz558wqadWiHrj4a555ZzwzWfaKw5yDrD8u13YugKu5KJ5kM66kyHktqqfZDACqHBoBR9lxSmu6NlBXz7Mjocq6rmQ9y_5c-A7j6Ho37pjxLXPeuhb9yNC3YcAxOtMza7zFyKJL15-YYZsQemwJN_0uucS6GAY2XiHDDfkOLvRhtWOhe0zDBp8CBdwO7PRcLMS7F9mzzvQJXx72k-znl_Mfi2_55fevF4vPl7ktq2rMW275UvBOKQFl2WDZysJAYWkVKAXHrq1Li8uyskQYQqBbQgdSdMChKOVJlu9102_cbJd6E91g4k4H4_Th6ZpOqBVXqpn4sz1PlgFbSzWJpn_g9tDi3ZVehV-6KJRsVEECb_YCluo2Oq99iEZzAFlpUTSFJOL0ECKGmy2mUQ8uWex74zFsk-ZlWQsFigT_A6VGK1FNqm__QddhG6lXe0pWNcAk-P42u5BSxO7uZxz0NFea5kpPc0XJEv36fjHu2NtBIuDDobpk8iuM94I-ovcXHaTXXQ</recordid><startdate>20150303</startdate><enddate>20150303</enddate><creator>Yang, H 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and incident endometrial cancer risk: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)</title><author>Yang, H P ; Cook, L S ; Weiderpass, E ; Adami, H-O ; Anderson, K E ; Cai, H ; Cerhan, J R ; Clendenen, T V ; Felix, A S ; Friedenreich, C M ; Garcia-Closas, M ; Goodman, M T ; Liang, X ; Lissowska, J ; Lu, L ; Magliocco, A M ; McCann, S E ; Moysich, K B ; Olson, S H ; Petruzella, S ; Pike, M C ; Polidoro, S ; Ricceri, F ; Risch, H A ; Sacerdote, C ; Setiawan, V W ; Shu, X O ; Spurdle, A B ; Trabert, B ; Webb, P M ; Wentzensen, N ; Xiang, Y-B ; Xu, Y ; Yu, H ; Zeleniuch-Jacquotte, A ; Brinton, L 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E</au><au>Adami, H-O</au><au>Anderson, K E</au><au>Cai, H</au><au>Cerhan, J R</au><au>Clendenen, T V</au><au>Felix, A S</au><au>Friedenreich, C M</au><au>Garcia-Closas, M</au><au>Goodman, M T</au><au>Liang, X</au><au>Lissowska, J</au><au>Lu, L</au><au>Magliocco, A M</au><au>McCann, S E</au><au>Moysich, K B</au><au>Olson, S H</au><au>Petruzella, S</au><au>Pike, M C</au><au>Polidoro, S</au><au>Ricceri, F</au><au>Risch, H A</au><au>Sacerdote, C</au><au>Setiawan, V W</au><au>Shu, X O</au><au>Spurdle, A B</au><au>Trabert, B</au><au>Webb, P M</au><au>Wentzensen, N</au><au>Xiang, Y-B</au><au>Xu, Y</au><au>Yu, H</au><au>Zeleniuch-Jacquotte, A</au><au>Brinton, L A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infertility and incident endometrial cancer risk: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2015-03-03</date><risdate>2015</risdate><volume>112</volume><issue>5</issue><spage>925</spage><epage>933</epage><pages>925-933</pages><issn>0007-0920</issn><issn>1532-1827</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes.
Methods:
We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided self-reported infertility and its causes, except for one study that relied on data from national registries. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI).
Results:
Nulliparous women had an elevated endometrial cancer risk compared with parous women, even after adjusting for infertility (OR=1.76; 95% CI: 1.59–1.94). Women who reported infertility had an increased risk compared with those without infertility concerns, even after adjusting for nulliparity (OR=1.22; 95% CI: 1.13–1.33). Among women who reported infertility, none of the individual infertility causes were substantially related to endometrial cancer.
Conclusions:
Based on mainly self-reported infertility data that used study-specific definitions of infertility, nulliparity and infertility appeared to independently contribute to endometrial cancer risk. Understanding residual endometrial cancer risk related to infertility, its causes and its treatments may benefit from large studies involving detailed data on various infertility parameters.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25688738</pmid><doi>10.1038/bjc.2015.24</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2015-03, Vol.112 (5), p.925-933 |
| issn | 0007-0920 1532-1827 1532-1827 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_515596 |
| source | MEDLINE; NORA - Norwegian Open Research Archives; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; SpringerLink Journals - AutoHoldings |
| subjects | 692/699/2732/1577 692/699/67/1517/1931 692/699/67/2324 Adult Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Research Cohort Studies Drug Resistance Endometrial Neoplasms - epidemiology Endometrial Neoplasms - etiology Epidemiology Female Humans Infertility, Female - epidemiology Logistic Models Middle Aged Molecular Medicine Oncology Parity Risk Factors Self Report |
| title | Infertility and incident endometrial cancer risk: a pooled analysis from the epidemiology of endometrial cancer consortium (E2C2) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T16%3A23%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Infertility%20and%20incident%20endometrial%20cancer%20risk:%20a%20pooled%20analysis%20from%20the%20epidemiology%20of%20endometrial%20cancer%20consortium%20(E2C2)&rft.jtitle=British%20journal%20of%20cancer&rft.au=Yang,%20H%20P&rft.date=2015-03-03&rft.volume=112&rft.issue=5&rft.spage=925&rft.epage=933&rft.pages=925-933&rft.issn=0007-0920&rft.eissn=1532-1827&rft.coden=BJCAAI&rft_id=info:doi/10.1038/bjc.2015.24&rft_dat=%3Cproquest_swepu%3E3613102801%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1660378005&rft_id=info:pmid/25688738&rfr_iscdi=true |