Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice

Helicobacter pylori , is an invariably commensal resident of the gut microbiome associated with gastric ulcer in adults. In addition, these patients also suffered from a low grade inflammation that activates the immune system and thus increased shunting of energy to host defense mechanisms. To asses...

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Veröffentlicht in:	Scientific reports 2015-03, Vol.5 (1), p.8731-8731, Article 8731
Hauptverfasser:	Khosravi, Yalda, Seow, Shih Wee, Amoyo, Arlaine Anne, Chiow, Kher Hsin, Tan, Tuan Lin, Wong, Whye Yen, Poh, Qian Hui, Sentosa, Ignatius Mario Doli, Bunte, Ralph M., Pettersson, Sven, Loke, Mun Fai, Vadivelu, Jamuna
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Sprache:	eng
Schlagworte:	13/1 13/106 13/21 631/326/2565/107 64/60 692/308/1426 Animals Body Mass Index Body weight Chemokine CCL11 - metabolism Defense mechanisms Energy Energy Metabolism Eotaxin Gastrointestinal tract Ghrelin Ghrelin - metabolism Growth curves Helicobacter Infections - metabolism Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - physiology Hormones Host-Pathogen Interactions Humanities and Social Sciences Humans Immune system Insulin Insulin - metabolism Intestinal microflora Intestine, Large - metabolism Intestine, Large - microbiology Leptin Leptin - metabolism Malnutrition Metabolism Mice, Inbred C57BL Microbiota - physiology Models, Biological multidisciplinary Pathogens Peptide Hormones - metabolism Peptide YY - metabolism Science Side effects Specific Pathogen-Free Organisms Weight Gain - physiology
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creator	Khosravi, Yalda Seow, Shih Wee Amoyo, Arlaine Anne Chiow, Kher Hsin Tan, Tuan Lin Wong, Whye Yen Poh, Qian Hui Sentosa, Ignatius Mario Doli Bunte, Ralph M. Pettersson, Sven Loke, Mun Fai Vadivelu, Jamuna
description	Helicobacter pylori , is an invariably commensal resident of the gut microbiome associated with gastric ulcer in adults. In addition, these patients also suffered from a low grade inflammation that activates the immune system and thus increased shunting of energy to host defense mechanisms. To assess whether a H. pylori infection could affect growth in early life, we determined the expression levels of selected metabolic gut hormones in germ free (GF) and specific pathogen-free (SPF) mice with and without the presence of H. pylori . Despite H. pylori -infected (SPFH) mice display alteration in host metabolism (elevated levels of leptin, insulin and peptide YY) compared to non-infected SPF mice, their growth curves remained the same. SPFH mice also displayed increased level of eotaxin-1. Interestingly, GF mice infected with H. pylori (GFH) also displayed increased levels of ghrelin and PYY. However, in contrast to SPFH mice, GFH showed reduced weight gain and malnutrition. These preliminary findings show that exposure to H. pylori alters host metabolism early in life; but the commensal microbiota in SPF mice can attenuate the growth retarding effect from H. pylori observed in GF mice. Further investigations of possible additional side effects of H. pylori are highly warranted.
doi_str_mv	10.1038/srep08731
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In addition, these patients also suffered from a low grade inflammation that activates the immune system and thus increased shunting of energy to host defense mechanisms. To assess whether a H. pylori infection could affect growth in early life, we determined the expression levels of selected metabolic gut hormones in germ free (GF) and specific pathogen-free (SPF) mice with and without the presence of H. pylori . Despite H. pylori -infected (SPFH) mice display alteration in host metabolism (elevated levels of leptin, insulin and peptide YY) compared to non-infected SPF mice, their growth curves remained the same. SPFH mice also displayed increased level of eotaxin-1. Interestingly, GF mice infected with H. pylori (GFH) also displayed increased levels of ghrelin and PYY. However, in contrast to SPFH mice, GFH showed reduced weight gain and malnutrition. These preliminary findings show that exposure to H. pylori alters host metabolism early in life; but the commensal microbiota in SPF mice can attenuate the growth retarding effect from H. pylori observed in GF mice. Further investigations of possible additional side effects of H. pylori are highly warranted.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep08731</identifier><identifier>PMID: 25736205</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/1 ; 13/106 ; 13/21 ; 631/326/2565/107 ; 64/60 ; 692/308/1426 ; Animals ; Body Mass Index ; Body weight ; Chemokine CCL11 - metabolism ; Defense mechanisms ; Energy ; Energy Metabolism ; Eotaxin ; Gastrointestinal tract ; Ghrelin ; Ghrelin - metabolism ; Growth curves ; Helicobacter Infections - metabolism ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Helicobacter pylori - physiology ; Hormones ; Host-Pathogen Interactions ; Humanities and Social Sciences ; Humans ; Immune system ; Insulin ; Insulin - metabolism ; Intestinal microflora ; Intestine, Large - metabolism ; Intestine, Large - microbiology ; Leptin ; Leptin - metabolism ; Malnutrition ; Metabolism ; Mice, Inbred C57BL ; Microbiota - physiology ; Models, Biological ; multidisciplinary ; Pathogens ; Peptide Hormones - metabolism ; Peptide YY - metabolism ; Science ; Side effects ; Specific Pathogen-Free Organisms ; Weight Gain - physiology</subject><ispartof>Scientific reports, 2015-03, Vol.5 (1), p.8731-8731, Article 8731</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Mar 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited. All rights reserved 2015 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-83b9dc308d207dc9420a690866467f50d1ddaa8043350c36db5c64a90e42ffe43</citedby><cites>FETCH-LOGICAL-c542t-83b9dc308d207dc9420a690866467f50d1ddaa8043350c36db5c64a90e42ffe43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348668/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348668/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25736205$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:130826693$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Khosravi, Yalda</creatorcontrib><creatorcontrib>Seow, Shih Wee</creatorcontrib><creatorcontrib>Amoyo, Arlaine Anne</creatorcontrib><creatorcontrib>Chiow, Kher Hsin</creatorcontrib><creatorcontrib>Tan, Tuan Lin</creatorcontrib><creatorcontrib>Wong, Whye Yen</creatorcontrib><creatorcontrib>Poh, Qian Hui</creatorcontrib><creatorcontrib>Sentosa, Ignatius Mario Doli</creatorcontrib><creatorcontrib>Bunte, Ralph M.</creatorcontrib><creatorcontrib>Pettersson, Sven</creatorcontrib><creatorcontrib>Loke, Mun Fai</creatorcontrib><creatorcontrib>Vadivelu, Jamuna</creatorcontrib><title>Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Helicobacter pylori , is an invariably commensal resident of the gut microbiome associated with gastric ulcer in adults. In addition, these patients also suffered from a low grade inflammation that activates the immune system and thus increased shunting of energy to host defense mechanisms. To assess whether a H. pylori infection could affect growth in early life, we determined the expression levels of selected metabolic gut hormones in germ free (GF) and specific pathogen-free (SPF) mice with and without the presence of H. pylori . Despite H. pylori -infected (SPFH) mice display alteration in host metabolism (elevated levels of leptin, insulin and peptide YY) compared to non-infected SPF mice, their growth curves remained the same. SPFH mice also displayed increased level of eotaxin-1. Interestingly, GF mice infected with H. pylori (GFH) also displayed increased levels of ghrelin and PYY. However, in contrast to SPFH mice, GFH showed reduced weight gain and malnutrition. These preliminary findings show that exposure to H. pylori alters host metabolism early in life; but the commensal microbiota in SPF mice can attenuate the growth retarding effect from H. pylori observed in GF mice. Further investigations of possible additional side effects of H. pylori are highly warranted.</description><subject>13/1</subject><subject>13/106</subject><subject>13/21</subject><subject>631/326/2565/107</subject><subject>64/60</subject><subject>692/308/1426</subject><subject>Animals</subject><subject>Body Mass Index</subject><subject>Body weight</subject><subject>Chemokine CCL11 - metabolism</subject><subject>Defense mechanisms</subject><subject>Energy</subject><subject>Energy Metabolism</subject><subject>Eotaxin</subject><subject>Gastrointestinal tract</subject><subject>Ghrelin</subject><subject>Ghrelin - metabolism</subject><subject>Growth curves</subject><subject>Helicobacter Infections - metabolism</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - physiology</subject><subject>Hormones</subject><subject>Host-Pathogen Interactions</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immune system</subject><subject>Insulin</subject><subject>Insulin - 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metabolism</topic><topic>Defense mechanisms</topic><topic>Energy</topic><topic>Energy Metabolism</topic><topic>Eotaxin</topic><topic>Gastrointestinal tract</topic><topic>Ghrelin</topic><topic>Ghrelin - metabolism</topic><topic>Growth curves</topic><topic>Helicobacter Infections - metabolism</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - physiology</topic><topic>Hormones</topic><topic>Host-Pathogen Interactions</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immune system</topic><topic>Insulin</topic><topic>Insulin - metabolism</topic><topic>Intestinal microflora</topic><topic>Intestine, Large - metabolism</topic><topic>Intestine, Large - microbiology</topic><topic>Leptin</topic><topic>Leptin - metabolism</topic><topic>Malnutrition</topic><topic>Metabolism</topic><topic>Mice, Inbred C57BL</topic><topic>Microbiota - physiology</topic><topic>Models, Biological</topic><topic>multidisciplinary</topic><topic>Pathogens</topic><topic>Peptide Hormones - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khosravi, Yalda</au><au>Seow, Shih Wee</au><au>Amoyo, Arlaine Anne</au><au>Chiow, Kher Hsin</au><au>Tan, Tuan Lin</au><au>Wong, Whye Yen</au><au>Poh, Qian Hui</au><au>Sentosa, Ignatius Mario Doli</au><au>Bunte, Ralph M.</au><au>Pettersson, Sven</au><au>Loke, Mun Fai</au><au>Vadivelu, Jamuna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-03-04</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>8731</spage><epage>8731</epage><pages>8731-8731</pages><artnum>8731</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Helicobacter pylori , is an invariably commensal resident of the gut microbiome associated with gastric ulcer in adults. In addition, these patients also suffered from a low grade inflammation that activates the immune system and thus increased shunting of energy to host defense mechanisms. To assess whether a H. pylori infection could affect growth in early life, we determined the expression levels of selected metabolic gut hormones in germ free (GF) and specific pathogen-free (SPF) mice with and without the presence of H. pylori . Despite H. pylori -infected (SPFH) mice display alteration in host metabolism (elevated levels of leptin, insulin and peptide YY) compared to non-infected SPF mice, their growth curves remained the same. SPFH mice also displayed increased level of eotaxin-1. Interestingly, GF mice infected with H. pylori (GFH) also displayed increased levels of ghrelin and PYY. However, in contrast to SPFH mice, GFH showed reduced weight gain and malnutrition. These preliminary findings show that exposure to H. pylori alters host metabolism early in life; but the commensal microbiota in SPF mice can attenuate the growth retarding effect from H. pylori observed in GF mice. Further investigations of possible additional side effects of H. pylori are highly warranted.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25736205</pmid><doi>10.1038/srep08731</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects	13/1 13/106 13/21 631/326/2565/107 64/60 692/308/1426 Animals Body Mass Index Body weight Chemokine CCL11 - metabolism Defense mechanisms Energy Energy Metabolism Eotaxin Gastrointestinal tract Ghrelin Ghrelin - metabolism Growth curves Helicobacter Infections - metabolism Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - physiology Hormones Host-Pathogen Interactions Humanities and Social Sciences Humans Immune system Insulin Insulin - metabolism Intestinal microflora Intestine, Large - metabolism Intestine, Large - microbiology Leptin Leptin - metabolism Malnutrition Metabolism Mice, Inbred C57BL Microbiota - physiology Models, Biological multidisciplinary Pathogens Peptide Hormones - metabolism Peptide YY - metabolism Science Side effects Specific Pathogen-Free Organisms Weight Gain - physiology
title	Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice
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