Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function

The mechanisms underlying human natural killer (NK) cell phenotypic and functional heterogeneity are unknown. Here, we describe the emergence of diverse subsets of human NK cells selectively lacking expression of signaling proteins after human cytomegalovirus (HCMV) infection. The absence of B and m...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2015-03, Vol.42 (3), p.443-456
Hauptverfasser:	Schlums, Heinrich, Cichocki, Frank, Tesi, Bianca, Theorell, Jakob, Beziat, Vivien, Holmes, Tim D., Han, Hongya, Chiang, Samuel C.C., Foley, Bree, Mattsson, Kristin, Larsson, Stella, Schaffer, Marie, Malmberg, Karl-Johan, Ljunggren, Hans-Gustaf, Miller, Jeffrey S., Bryceson, Yenan T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Antibodies - immunology Antigens Biomedical research Cancer Cell Proliferation Cytokines Cytomegalovirus Cytomegalovirus - immunology Cytomegalovirus Infections - genetics Cytomegalovirus Infections - immunology Cytomegalovirus Infections - pathology Cytomegalovirus Infections - virology Cytotoxicity Data analysis Diversification DNA Methylation Epigenesis, Genetic - immunology Epigenetics Experiments Flow cytometry Gene expression Gene Expression Profiling GPI-Linked Proteins - genetics GPI-Linked Proteins - immunology Human cytomegalovirus Humans Immune system Immunophenotyping Infections Intracellular Signaling Peptides and Proteins - deficiency Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - immunology Killer Cells, Natural - classification Killer Cells, Natural - immunology Killer Cells, Natural - pathology Killer Cells, Natural - virology Kinases Kruppel-Like Transcription Factors - deficiency Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - immunology Leukemia Lymphocytes Microarray Analysis NK Cell Lectin-Like Receptor Subfamily C - deficiency NK Cell Lectin-Like Receptor Subfamily C - genetics NK Cell Lectin-Like Receptor Subfamily C - immunology Promoter Regions, Genetic Promyelocytic Leukemia Zinc Finger Protein Protein-Tyrosine Kinases - deficiency Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - immunology Proteins Receptors, IgG - deficiency Receptors, IgG - genetics Receptors, IgG - immunology Scholarships & fellowships Signal Transduction Syk Kinase T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - pathology T-Lymphocytes, Cytotoxic - virology Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - immunology Transplants & implants Viral infections
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