Neuroinflammation in Alzheimer's disease

Summary Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astrogl...

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Veröffentlicht in:	Lancet neurology 2015-04, Vol.14 (4), p.388-405
Hauptverfasser:	Heneka, Michael T, Prof, Carson, Monica J, Prof, Khoury, Joseph El, Prof, Landreth, Gary E, Prof, Brosseron, Frederic, PhD, Feinstein, Douglas L, Prof, Jacobs, Andreas H, Prof, Wyss-Coray, Tony, Prof, Vitorica, Javier, Prof, Ransohoff, Richard M, Prof, Herrup, Karl, Prof, Frautschy, Sally A, Prof, Finsen, Bente, Prof, Brown, Guy C, Prof, Verkhratsky, Alexei, Prof, Yamanaka, Koji, Prof, Koistinaho, Jari, Prof, Latz, Eicke, Prof, Halle, Annett, MD, Petzold, Gabor C, Prof, Town, Terrence, Prof, Morgan, Dave, Prof, Shinohara, Mari L, Prof, Perry, V Hugh, Prof, Holmes, Clive, Prof, Bazan, Nicolas G, Prof, Brooks, David J, Prof, Hunot, Stéphane, PhD, Joseph, Bertrand, Prof, Deigendesch, Nikolaus, MD, Garaschuk, Olga, Prof, Boddeke, Erik, Prof, Dinarello, Charles A, Prof, Breitner, John C, Prof, Cole, Greg M, Prof, Golenbock, Douglas T, Prof, Kummer, Markus P, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - immunology Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - prevention & control Alzheimer's disease Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Astrocytes - immunology Astrocytes - pathology Biomarkers - blood Biomarkers - cerebrospinal fluid Brain Injuries - complications Brain Injuries - metabolism Brain research Clinical Trials as Topic Cognitive ability Disease Models, Animal Disease Progression Gene expression Genotype & phenotype Humans Immune system Immunity, Innate Immunization Inflammation - diagnosis Inflammation - immunology Inflammation - metabolism Inflammation Mediators - immunology Inflammation Mediators - metabolism Life Sciences Ligands Locus Coeruleus - pathology Microglia - immunology Microglia - pathology Mutation Neurology Neurosciences Nootropic Agents - administration & dosage Obesity - complications Obesity - metabolism Pathogenesis Phagocytosis Physiology Protein Folding Risk Factors Severity of Illness Index
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