Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm
We investigated the risk of stroke related to long-term ambient air pollution exposure, in particular the role of various exposure time windows, using four cohorts from Stockholm County, Sweden. In total, 22,587 individuals were recruited from 1992 to 2004 and followed until 2011. Yearly air polluti...
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| Veröffentlicht in: | Journal of exposure science & environmental epidemiology 2015-09, Vol.25 (5), p.517-523 |
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| creator | Korek, Michal J Bellander, Tom D Lind, Tomas Bottai, Matteo Eneroth, Kristina M Caracciolo, Barbara de Faire, Ulf H Fratiglioni, Laura Hilding, Agneta Leander, Karin Magnusson, Patrik K E Pedersen, Nancy L Östenson, Claes-Göran Pershagen, Göran Penell, Johanna C |
| description | We investigated the risk of stroke related to long-term ambient air pollution exposure, in particular the role of various exposure time windows, using four cohorts from Stockholm County, Sweden. In total, 22,587 individuals were recruited from 1992 to 2004 and followed until 2011. Yearly air pollution levels resulting from local road traffic emissions were assessed at participant residences using dispersion models for particulate matter (PM
10
) and nitrogen oxides (NO
X
). Cohort-specific hazard ratios were estimated for time-weighted air pollution exposure during different time windows and the incidence of stroke, adjusted for common risk factors, and then meta-analysed. Overall, 868 subjects suffered a non-fatal or fatal stroke during 238,731 person-years of follow-up. An increment of 20
μ
g/m
3
in estimated annual mean of road-traffic related NO
X
exposure at recruitment was associated with a hazard ratio of 1.16 (95% CI 0.83–1.61), with evidence of heterogeneity between the cohorts. For PM
10
, an increment of 10
μ
g/m
3
corresponded to a hazard ratio of 1.14 (95% CI 0.68–1.90). Time-window analyses did not reveal any clear induction-latency pattern. In conclusion, we found suggestive evidence of an association between long-term exposure to NO
X
and PM
10
from local traffic and stroke at comparatively low levels of air pollution. |
| doi_str_mv | 10.1038/jes.2015.22 |
| format | Article |
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10
) and nitrogen oxides (NO
X
). Cohort-specific hazard ratios were estimated for time-weighted air pollution exposure during different time windows and the incidence of stroke, adjusted for common risk factors, and then meta-analysed. Overall, 868 subjects suffered a non-fatal or fatal stroke during 238,731 person-years of follow-up. An increment of 20
μ
g/m
3
in estimated annual mean of road-traffic related NO
X
exposure at recruitment was associated with a hazard ratio of 1.16 (95% CI 0.83–1.61), with evidence of heterogeneity between the cohorts. For PM
10
, an increment of 10
μ
g/m
3
corresponded to a hazard ratio of 1.14 (95% CI 0.68–1.90). Time-window analyses did not reveal any clear induction-latency pattern. In conclusion, we found suggestive evidence of an association between long-term exposure to NO
X
and PM
10
from local traffic and stroke at comparatively low levels of air pollution.</description><identifier>ISSN: 1559-0631</identifier><identifier>ISSN: 1559-064X</identifier><identifier>EISSN: 1559-064X</identifier><identifier>DOI: 10.1038/jes.2015.22</identifier><identifier>PMID: 25827311</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/699/75/593/1370/534 ; 692/700/478/174 ; 704/106/694/2739 ; Adult ; Aged ; Aged, 80 and over ; Air Pollutants - adverse effects ; Air pollution ; Air Pollution - adverse effects ; Cohort Studies ; Epidemiology ; Exposure ; exposure modeling ; Female ; Health aspects ; Health risks ; Heterogeneity ; Humans ; Incidence ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nitrogen Dioxide - adverse effects ; Nitrogen oxides ; Original ; original-article ; Particle Size ; Particulate matter ; Particulate Matter - adverse effects ; personal exposure ; Photochemicals ; Pollution levels ; Proportional Hazards Models ; Risk Factors ; Stroke (Disease) ; Stroke - epidemiology ; Stroke - etiology ; Sweden - epidemiology ; Twin Studies as Topic ; Vehicle Emissions</subject><ispartof>Journal of exposure science & environmental epidemiology, 2015-09, Vol.25 (5), p.517-523</ispartof><rights>The Author(s) 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2015</rights><rights>Copyright © 2015 Nature America, Inc. 2015 Nature America, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c718t-912edd66bc07a1498496efbad7ea4cf6905783de661dfe5278dcb1974cc5889f3</citedby><cites>FETCH-LOGICAL-c718t-912edd66bc07a1498496efbad7ea4cf6905783de661dfe5278dcb1974cc5889f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jes.2015.22$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jes.2015.22$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,551,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25827311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-121505$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:131885360$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Korek, Michal J</creatorcontrib><creatorcontrib>Bellander, Tom D</creatorcontrib><creatorcontrib>Lind, Tomas</creatorcontrib><creatorcontrib>Bottai, Matteo</creatorcontrib><creatorcontrib>Eneroth, Kristina M</creatorcontrib><creatorcontrib>Caracciolo, Barbara</creatorcontrib><creatorcontrib>de Faire, Ulf H</creatorcontrib><creatorcontrib>Fratiglioni, Laura</creatorcontrib><creatorcontrib>Hilding, Agneta</creatorcontrib><creatorcontrib>Leander, Karin</creatorcontrib><creatorcontrib>Magnusson, Patrik K E</creatorcontrib><creatorcontrib>Pedersen, Nancy L</creatorcontrib><creatorcontrib>Östenson, Claes-Göran</creatorcontrib><creatorcontrib>Pershagen, Göran</creatorcontrib><creatorcontrib>Penell, Johanna C</creatorcontrib><title>Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm</title><title>Journal of exposure science & environmental epidemiology</title><addtitle>J Expo Sci Environ Epidemiol</addtitle><addtitle>J Expo Sci Environ Epidemiol</addtitle><description>We investigated the risk of stroke related to long-term ambient air pollution exposure, in particular the role of various exposure time windows, using four cohorts from Stockholm County, Sweden. In total, 22,587 individuals were recruited from 1992 to 2004 and followed until 2011. Yearly air pollution levels resulting from local road traffic emissions were assessed at participant residences using dispersion models for particulate matter (PM
10
) and nitrogen oxides (NO
X
). Cohort-specific hazard ratios were estimated for time-weighted air pollution exposure during different time windows and the incidence of stroke, adjusted for common risk factors, and then meta-analysed. Overall, 868 subjects suffered a non-fatal or fatal stroke during 238,731 person-years of follow-up. An increment of 20
μ
g/m
3
in estimated annual mean of road-traffic related NO
X
exposure at recruitment was associated with a hazard ratio of 1.16 (95% CI 0.83–1.61), with evidence of heterogeneity between the cohorts. For PM
10
, an increment of 10
μ
g/m
3
corresponded to a hazard ratio of 1.14 (95% CI 0.68–1.90). Time-window analyses did not reveal any clear induction-latency pattern. In conclusion, we found suggestive evidence of an association between long-term exposure to NO
X
and PM
10
from local traffic and stroke at comparatively low levels of air pollution.</description><subject>692/699/75/593/1370/534</subject><subject>692/700/478/174</subject><subject>704/106/694/2739</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Air Pollutants - adverse effects</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Cohort Studies</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>exposure modeling</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nitrogen Dioxide - adverse effects</subject><subject>Nitrogen oxides</subject><subject>Original</subject><subject>original-article</subject><subject>Particle Size</subject><subject>Particulate matter</subject><subject>Particulate Matter - adverse effects</subject><subject>personal exposure</subject><subject>Photochemicals</subject><subject>Pollution levels</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><subject>Stroke (Disease)</subject><subject>Stroke - epidemiology</subject><subject>Stroke - etiology</subject><subject>Sweden - epidemiology</subject><subject>Twin Studies as Topic</subject><subject>Vehicle 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air pollution exposure and incidence of stroke in four cohorts from Stockholm</title><author>Korek, Michal J ; Bellander, Tom D ; Lind, Tomas ; Bottai, Matteo ; Eneroth, Kristina M ; Caracciolo, Barbara ; de Faire, Ulf H ; Fratiglioni, Laura ; Hilding, Agneta ; Leander, Karin ; Magnusson, Patrik K E ; Pedersen, Nancy L ; Östenson, Claes-Göran ; Pershagen, Göran ; Penell, Johanna C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c718t-912edd66bc07a1498496efbad7ea4cf6905783de661dfe5278dcb1974cc5889f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>692/699/75/593/1370/534</topic><topic>692/700/478/174</topic><topic>704/106/694/2739</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Air Pollutants - adverse effects</topic><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Cohort 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Korek, Michal J</au><au>Bellander, Tom D</au><au>Lind, Tomas</au><au>Bottai, Matteo</au><au>Eneroth, Kristina M</au><au>Caracciolo, Barbara</au><au>de Faire, Ulf H</au><au>Fratiglioni, Laura</au><au>Hilding, Agneta</au><au>Leander, Karin</au><au>Magnusson, Patrik K E</au><au>Pedersen, Nancy L</au><au>Östenson, Claes-Göran</au><au>Pershagen, Göran</au><au>Penell, Johanna C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm</atitle><jtitle>Journal of exposure science & environmental epidemiology</jtitle><stitle>J Expo Sci Environ Epidemiol</stitle><addtitle>J Expo Sci Environ Epidemiol</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>25</volume><issue>5</issue><spage>517</spage><epage>523</epage><pages>517-523</pages><issn>1559-0631</issn><issn>1559-064X</issn><eissn>1559-064X</eissn><abstract>We investigated the risk of stroke related to long-term ambient air pollution exposure, in particular the role of various exposure time windows, using four cohorts from Stockholm County, Sweden. In total, 22,587 individuals were recruited from 1992 to 2004 and followed until 2011. Yearly air pollution levels resulting from local road traffic emissions were assessed at participant residences using dispersion models for particulate matter (PM
10
) and nitrogen oxides (NO
X
). Cohort-specific hazard ratios were estimated for time-weighted air pollution exposure during different time windows and the incidence of stroke, adjusted for common risk factors, and then meta-analysed. Overall, 868 subjects suffered a non-fatal or fatal stroke during 238,731 person-years of follow-up. An increment of 20
μ
g/m
3
in estimated annual mean of road-traffic related NO
X
exposure at recruitment was associated with a hazard ratio of 1.16 (95% CI 0.83–1.61), with evidence of heterogeneity between the cohorts. For PM
10
, an increment of 10
μ
g/m
3
corresponded to a hazard ratio of 1.14 (95% CI 0.68–1.90). Time-window analyses did not reveal any clear induction-latency pattern. In conclusion, we found suggestive evidence of an association between long-term exposure to NO
X
and PM
10
from local traffic and stroke at comparatively low levels of air pollution.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>25827311</pmid><doi>10.1038/jes.2015.22</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1559-0631 |
| ispartof | Journal of exposure science & environmental epidemiology, 2015-09, Vol.25 (5), p.517-523 |
| issn | 1559-0631 1559-064X 1559-064X |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_514579 |
| source | MEDLINE; SWEPUB Freely available online; SpringerLink Journals - AutoHoldings |
| subjects | 692/699/75/593/1370/534 692/700/478/174 704/106/694/2739 Adult Aged Aged, 80 and over Air Pollutants - adverse effects Air pollution Air Pollution - adverse effects Cohort Studies Epidemiology Exposure exposure modeling Female Health aspects Health risks Heterogeneity Humans Incidence Male Medicine Medicine & Public Health Middle Aged Nitrogen Dioxide - adverse effects Nitrogen oxides Original original-article Particle Size Particulate matter Particulate Matter - adverse effects personal exposure Photochemicals Pollution levels Proportional Hazards Models Risk Factors Stroke (Disease) Stroke - epidemiology Stroke - etiology Sweden - epidemiology Twin Studies as Topic Vehicle Emissions |
| title | Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T04%3A34%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Traffic-related%20air%20pollution%20exposure%20and%20incidence%20of%20stroke%20in%20four%20cohorts%20from%20Stockholm&rft.jtitle=Journal%20of%20exposure%20science%20&%20environmental%20epidemiology&rft.au=Korek,%20Michal%20J&rft.date=2015-09-01&rft.volume=25&rft.issue=5&rft.spage=517&rft.epage=523&rft.pages=517-523&rft.issn=1559-0631&rft.eissn=1559-064X&rft_id=info:doi/10.1038/jes.2015.22&rft_dat=%3Cgale_swepu%3EA427666314%3C/gale_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1704962978&rft_id=info:pmid/25827311&rft_galeid=A427666314&rfr_iscdi=true |