Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles

Background Children with problematic severe asthma have poor disease control despite high doses of inhaled corticosteroids and additional therapy, leading to personal suffering, early deterioration of lung function, and significant consumption of health care resources. If no exacerbating factors, su...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2015-09, Vol.136 (3), p.638-648
Hauptverfasser:	Persson, Helena, PhD, Kwon, Andrew T., PhD, Ramilowski, Jordan A., PhD, Silberberg, Gilad, PhD, Söderhäll, Cilla, PhD, Orsmark-Pietras, Christina, PhD, Nordlund, Björn, RN, PhD, Konradsen, Jon R., MD, PhD, de Hoon, Michiel J.L., PhD, Melén, Erik, MD, PhD, Hayashizaki, Yoshihide, MD, PhD, Hedlin, Gunilla, MD, PhD, Kere, Juha, MD, PhD, Daub, Carsten O., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Allergy and Immunology Asthma Asthma - drug therapy Asthma - genetics Asthma - pathology Case-Control Studies Child Child, Preschool childhood asthma Drug Resistance - genetics Female Gene expression Gene Expression Profiling Genome-Wide Association Study Glucocorticoids - therapeutic use Humans JNK Mitogen-Activated Protein Kinases - genetics long noncoding RNA Male Medicin och hälsovetenskap Nuclear Receptor Subfamily 1, Group F, Member 1 - genetics peripheral blood leukocytes Receptors, Glucocorticoid - genetics RNA polymerase RNA, Messenger - genetics Severity of Illness Index Therapy-resistant asthma Transcriptome
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