The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells

The Rho GTPase Cdc42 coordinates regulation of the actin and the microtubule cytoskeleton by binding and activating the Wiskott-Aldrich syndrome protein. We sought to define the role of intrinsic expression of Cdc42 by mature B cells in their activation and function. Mice with inducible deletion of...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-05, Vol.194 (10), p.4750-4758
Hauptverfasser:	Gerasimcik, Natalija, Dahlberg, Carin I M, Baptista, Marisa A P, Massaad, Michel J, Geha, Raif S, Westerberg, Lisa S, Severinson, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - immunology Blotting, Western cdc42 GTP-Binding Protein - immunology Cell Differentiation - immunology Cell Movement - immunology Flow Cytometry Immune Regulation Immunohistochemistry Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mice, Mutant Strains
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