Chlorambucil plus ofatumumab versus chlorambucil alone in previously untreated patients with chronic lymphocytic leukaemia (COMPLEMENT 1): a randomised, multicentre, open-label phase 3 trial

Summary Background Treatment for patients with chronic lymphocytic leukaemia who are elderly or who have comorbidities is challenging because fludarabine-based chemoimmunotherapies are mostly not suitable. Chlorambucil remains the standard of care in many countries. We aimed to investigate whether t...

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Veröffentlicht in:	The Lancet (British edition) 2015-05, Vol.385 (9980), p.1873-1883
Hauptverfasser:	Hillmen, Peter, Prof, Robak, Tadeusz, MD, Janssens, Ann, MD, Babu, K Govind, MD, Kloczko, Janusz, MD, Grosicki, Sebastian, MD, Doubek, Michael, MD, Panagiotidis, Panagiotis, MD, Kimby, Eva, MD, Schuh, Anna, MD, Pettitt, Andrew R, MRCPath, Boyd, Thomas, MD, Montillo, Marco, MD, Gupta, Ira V, MD, Wright, Oliver, BSc, Dixon, Iestyn, BSc, Carey, Jodi L, RN BSN, Chang, Chai-Ni, MS, Lisby, Steen, MD, McKeown, Astrid, PhD, Offner, Fritz, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Age Distribution Aged Aged, 80 and over Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Agents, Alkylating - adverse effects Antineoplastic Agents, Alkylating - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Binding sites Bone marrow Chlorambucil - administration & dosage Chlorambucil - adverse effects Chlorambucil - therapeutic use Cytotoxicity Drug Administration Schedule Drug dosages Female Flow cytometry Geriatrics Humans Immunoglobulins Infections Internal Medicine Kaplan-Meier Estimate Laboratories Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Male Medical imaging Medical research Middle Aged Neutropenia Ovarian cancer Prospective Studies Sex Distribution Treatment Outcome
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