Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells

Common variable immunodeficiency disorder (CVID) is the most common symptomatic primary immunodeficiency in adults, characterized by B-cell abnormalities and inadequate antibody response. CVID patients have considerable autoimmune comorbidity and we therefore hypothesized that genetic susceptibility...

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Veröffentlicht in:	Nature communications 2015-04, Vol.6 (1), p.6804-6804, Article 6804
Hauptverfasser:	Li, Jin, Jørgensen, Silje F., Maggadottir, S Melkorka, Bakay, Marina, Warnatz, Klaus, Glessner, Joseph, Pandey, Rahul, Salzer, Ulrich, Schmidt, Reinhold E., Perez, Elena, Resnick, Elena, Goldacker, Sigune, Buchta, Mary, Witte, Torsten, Padyukov, Leonid, Videm, Vibeke, Folseraas, Trine, Atschekzei, Faranaz, Elder, James T., Nair, Rajan P., Winkelmann, Juliane, Gieger, Christian, Nöthen, Markus M., Büning, Carsten, Brand, Stephan, Sullivan, Kathleen E., Orange, Jordan S., Fevang, Børre, Schreiber, Stefan, Lieb, Wolfgang, Aukrust, Pål, Chapel, Helen, Cunningham-Rundles, Charlotte, Franke, Andre, Karlsen, Tom H., Grimbacher, Bodo, Hakonarson, Hakon, Hammarström, Lennart, Ellinghaus, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205 631/208/2489/144 631/250/1619/40 692/699/249/2512 Animals B-Lymphocytes - metabolism Case-Control Studies Cells, Cultured Common Variable Immunodeficiency - epidemiology Common Variable Immunodeficiency - genetics Europe - epidemiology Gene Expression Regulation - physiology Genetic Predisposition to Disease Genome-Wide Association Study Humanities and Social Sciences Humans Lectins, C-Type - genetics Lectins, C-Type - metabolism Logistic Models Mice Monosaccharide Transport Proteins - genetics Monosaccharide Transport Proteins - metabolism multidisciplinary Odds Ratio Polymorphism, Single Nucleotide Science Science (multidisciplinary) Spleen - cytology United States - epidemiology
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