The influence of nevirapine and efavirenz-based anti-retroviral therapy on the pharmacokinetics of lumefantrine and anti-malarial dose recommendation in HIV-malaria co-treatment

HIV-malaria co-infected patients in most parts of sub-Saharan Africa are treated with both artemether-lumefantrine (AL) and efavirenz (EFV) or nevirapine (NVP)-based antiretroviral therapy (ART). EFV, NVP, artemether and lumefantrine are substrates, inhibitors or inducers of CYP3A4 and CYP2B6, creat...

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Veröffentlicht in:	MALARIA JOURNAL 2015-04, Vol.14 (1), p.179-179, Article 179
Hauptverfasser:	Maganda, Betty A, Ngaimisi, Eliford, Kamuhabwa, Appolinary A R, Aklillu, Eleni, Minzi, Omary M S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Anti-Retroviral Agents - pharmacokinetics Anti-Retroviral Agents - therapeutic use Antimalarials - pharmacokinetics Benzoxazines - pharmacokinetics Cytochrome P-450 Drug Interactions Ethanolamines - pharmacokinetics Female Fluorenes - pharmacokinetics Health aspects HIV Infections - drug therapy Humans Malaria - drug therapy Male Medicin och hälsovetenskap Middle Aged Nevirapine - pharmacokinetics Prospective Studies Reverse transcriptase inhibitors Tanzania Young Adult
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