The impact of low-frequency and rare variants on lipid levels

Samuli Ripatti and colleagues report the results of a genome-wide association study for circulating lipid levels based on 1000 Genomes Project imputation. Their results implicate several new loci, refine the association signals at many established loci and highlight the impact of low-frequency varia...

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Veröffentlicht in:	Nature genetics 2015-06, Vol.47 (6), p.589-597
Hauptverfasser:	Surakka, Ida, Horikoshi, Momoko, Mägi, Reedik, Sarin, Antti-Pekka, Mahajan, Anubha, Lagou, Vasiliki, Marullo, Letizia, Ferreira, Teresa, Miraglio, Benjamin, Timonen, Sanna, Kettunen, Johannes, Pirinen, Matti, Karjalainen, Juha, Thorleifsson, Gudmar, Hägg, Sara, Hottenga, Jouke-Jan, Isaacs, Aaron, Ladenvall, Claes, Beekman, Marian, Esko, Tõnu, Ried, Janina S, Nelson, Christopher P, Willenborg, Christina, Gustafsson, Stefan, Westra, Harm-Jan, Blades, Matthew, de Craen, Anton J M, de Geus, Eco J, Deelen, Joris, Grallert, Harald, Hamsten, Anders, Havulinna, Aki S, Hengstenberg, Christian, Houwing-Duistermaat, Jeanine J, Hyppönen, Elina, Karssen, Lennart C, Lehtimäki, Terho, Lyssenko, Valeriya, Magnusson, Patrik K E, Mihailov, Evelin, Müller-Nurasyid, Martina, Mpindi, John-Patrick, Pedersen, Nancy L, Penninx, Brenda W J H, Perola, Markus, Pers, Tune H, Peters, Annette, Rung, Johan, Smit, Johannes H, Steinthorsdottir, Valgerdur, Tobin, Martin D, Tsernikova, Natalia, van Leeuwen, Elisabeth M, Viikari, Jorma S, Willems, Sara M, Willemsen, Gonneke, Schunkert, Heribert, Erdmann, Jeanette, Samani, Nilesh J, Kaprio, Jaakko, Lind, Lars, Gieger, Christian, Metspalu, Andres, Slagboom, P Eline, Groop, Leif, van Duijn, Cornelia M, Eriksson, Johan G, Jula, Antti, Salomaa, Veikko, Boomsma, Dorret I, Power, Christine, Raitakari, Olli T, Ingelsson, Erik, Järvelin, Marjo-Riitta, Thorsteinsdottir, Unnur, Franke, Lude, Ikonen, Elina, Kallioniemi, Olli, Pietiäinen, Vilja, Lindgren, Cecilia M, Stefansson, Kari, Palotie, Aarno, McCarthy, Mark I, Morris, Andrew P, Prokopenko, Inga, Ripatti, Samuli
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/43 631/208/205/2138 Agreements Agriculture Animal Genetics and Genomics Biomedicine Cancer Research Cholesterol Clinical Medicine Design Dyslipidemias - genetics Endocrinology and Diabetes Endokrinologi och diabetes Gene Frequency Gene Function Genetic aspects Genetic Loci Genetic variance Genetics Genome-Wide Association Study Health aspects Human Genetics Humans Identification and classification Klinisk medicin Linkage Disequilibrium Lipid metabolism Lipid Metabolism - genetics Lipids Medical and Health Sciences Medicin och hälsovetenskap Mutation, Missense Polymorphism, Single Nucleotide Sequence Analysis, DNA Single nucleotide polymorphisms Studies
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