Non-Hodgkin Lymphoma, Body Mass Index, and Cytokine Polymorphisms: A Pooled Analysis from the InterLymph Consortium
Excess adiposity has been associated with lymphomagenesis, possibly mediated by increased cytokine production causing a chronic inflammatory state. The relationship between obesity, cytokine polymorphisms, and selected mature B-cell neoplasms is reported. Data on 4,979 cases and 4,752 controls from...
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| Veröffentlicht in: | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 2015-07, Vol.24 (7), p.1061-1070 |
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| creator | Kane, Eleanor Skibola, Christine F Bracci, Paige M Cerhan, James R Costas, Laura Smedby, Karin Ekström Holly, Elizabeth A Maynadié, Marc Novak, Anne J Lightfoot, Tracy J Ansell, Stephen M Smith, Alex G Liebow, Mark Melbye, Mads Morton, Lindsay de Sanjosé, Silvia Slager, Susan L Wang, Sophia S Zhang, Yawei Zheng, Tongzhang Roman, Eve |
| description | Excess adiposity has been associated with lymphomagenesis, possibly mediated by increased cytokine production causing a chronic inflammatory state. The relationship between obesity, cytokine polymorphisms, and selected mature B-cell neoplasms is reported.
Data on 4,979 cases and 4,752 controls from nine American/European studies from the InterLymph consortium (1988-2008) were pooled. For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression. BMI-polymorphism interaction effects were estimated using the relative excess risk due to interaction (RERI).
Obesity (BMI ≥ 30 kg/m(2)) was associated with DLBCL risk [OR = 1.33; 95% confidence interval (CI), 1.02-1.73], as was TNF-308GA+AA (OR = 1.24; 95% CI, 1.07-1.44). Together, being obese and TNF-308GA+AA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95% CI, 1.27-2.94), with a RERI of 0.41 (95% CI, -0.05-0.84; Pinteraction = 0.13). For FL and CLL/SLL, no associations with obesity or TNF-308GA+AA, either singly or jointly, were observed. No evidence of interactions between obesity and the other polymorphisms were detected.
Our results suggest that cytokine polymorphisms do not generally interact with BMI to increase lymphoma risk but obesity and TNF-308GA+AA may interact to increase DLBCL risk.
Studies using better measures of adiposity are needed to further investigate the interactions between obesity and TNF-308G>A in the pathogenesis of lymphoma. |
| doi_str_mv | 10.1158/1055-9965.EPI-14-1355 |
| format | Article |
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Data on 4,979 cases and 4,752 controls from nine American/European studies from the InterLymph consortium (1988-2008) were pooled. For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression. BMI-polymorphism interaction effects were estimated using the relative excess risk due to interaction (RERI).
Obesity (BMI ≥ 30 kg/m(2)) was associated with DLBCL risk [OR = 1.33; 95% confidence interval (CI), 1.02-1.73], as was TNF-308GA+AA (OR = 1.24; 95% CI, 1.07-1.44). Together, being obese and TNF-308GA+AA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95% CI, 1.27-2.94), with a RERI of 0.41 (95% CI, -0.05-0.84; Pinteraction = 0.13). For FL and CLL/SLL, no associations with obesity or TNF-308GA+AA, either singly or jointly, were observed. No evidence of interactions between obesity and the other polymorphisms were detected.
Our results suggest that cytokine polymorphisms do not generally interact with BMI to increase lymphoma risk but obesity and TNF-308GA+AA may interact to increase DLBCL risk.
Studies using better measures of adiposity are needed to further investigate the interactions between obesity and TNF-308G>A in the pathogenesis of lymphoma.</description><identifier>ISSN: 1055-9965</identifier><identifier>ISSN: 1538-7755</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-14-1355</identifier><identifier>PMID: 25962811</identifier><language>eng</language><publisher>United States</publisher><subject>Adiposity - genetics ; Adult ; Aged ; Body Mass Index ; Cytokines - genetics ; Cytokines - metabolism ; DNA, Neoplasm - genetics ; Female ; Genetic Predisposition to Disease ; Humans ; Lymphangiogenesis - genetics ; Lymphoma, Large B-Cell, Diffuse - genetics ; Lymphoma, Large B-Cell, Diffuse - immunology ; Lymphoma, Large B-Cell, Diffuse - metabolism ; Male ; Middle Aged ; Polymorphism, Genetic ; Retrospective Studies ; Risk Factors ; Young Adult</subject><ispartof>CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2015-07, Vol.24 (7), p.1061-1070</ispartof><rights>2015 American Association for Cancer Research.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-65d46d8b0d48b6531c6e08cf34a5a914e9cfb3bac03a012e33decd10150b677f3</citedby><cites>FETCH-LOGICAL-c449t-65d46d8b0d48b6531c6e08cf34a5a914e9cfb3bac03a012e33decd10150b677f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,3343,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25962811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:131579485$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kane, Eleanor</creatorcontrib><creatorcontrib>Skibola, Christine F</creatorcontrib><creatorcontrib>Bracci, Paige M</creatorcontrib><creatorcontrib>Cerhan, James R</creatorcontrib><creatorcontrib>Costas, Laura</creatorcontrib><creatorcontrib>Smedby, Karin Ekström</creatorcontrib><creatorcontrib>Holly, Elizabeth A</creatorcontrib><creatorcontrib>Maynadié, Marc</creatorcontrib><creatorcontrib>Novak, Anne J</creatorcontrib><creatorcontrib>Lightfoot, Tracy J</creatorcontrib><creatorcontrib>Ansell, Stephen M</creatorcontrib><creatorcontrib>Smith, Alex G</creatorcontrib><creatorcontrib>Liebow, Mark</creatorcontrib><creatorcontrib>Melbye, Mads</creatorcontrib><creatorcontrib>Morton, Lindsay</creatorcontrib><creatorcontrib>de Sanjosé, Silvia</creatorcontrib><creatorcontrib>Slager, Susan L</creatorcontrib><creatorcontrib>Wang, Sophia S</creatorcontrib><creatorcontrib>Zhang, Yawei</creatorcontrib><creatorcontrib>Zheng, Tongzhang</creatorcontrib><creatorcontrib>Roman, Eve</creatorcontrib><title>Non-Hodgkin Lymphoma, Body Mass Index, and Cytokine Polymorphisms: A Pooled Analysis from the InterLymph Consortium</title><title>CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Excess adiposity has been associated with lymphomagenesis, possibly mediated by increased cytokine production causing a chronic inflammatory state. The relationship between obesity, cytokine polymorphisms, and selected mature B-cell neoplasms is reported.
Data on 4,979 cases and 4,752 controls from nine American/European studies from the InterLymph consortium (1988-2008) were pooled. For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression. BMI-polymorphism interaction effects were estimated using the relative excess risk due to interaction (RERI).
Obesity (BMI ≥ 30 kg/m(2)) was associated with DLBCL risk [OR = 1.33; 95% confidence interval (CI), 1.02-1.73], as was TNF-308GA+AA (OR = 1.24; 95% CI, 1.07-1.44). Together, being obese and TNF-308GA+AA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95% CI, 1.27-2.94), with a RERI of 0.41 (95% CI, -0.05-0.84; Pinteraction = 0.13). For FL and CLL/SLL, no associations with obesity or TNF-308GA+AA, either singly or jointly, were observed. No evidence of interactions between obesity and the other polymorphisms were detected.
Our results suggest that cytokine polymorphisms do not generally interact with BMI to increase lymphoma risk but obesity and TNF-308GA+AA may interact to increase DLBCL risk.
Studies using better measures of adiposity are needed to further investigate the interactions between obesity and TNF-308G>A in the pathogenesis of lymphoma.</description><subject>Adiposity - genetics</subject><subject>Adult</subject><subject>Aged</subject><subject>Body Mass Index</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>DNA, Neoplasm - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Lymphangiogenesis - genetics</subject><subject>Lymphoma, Large B-Cell, Diffuse - genetics</subject><subject>Lymphoma, Large B-Cell, Diffuse - immunology</subject><subject>Lymphoma, Large B-Cell, Diffuse - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Young Adult</subject><issn>1055-9965</issn><issn>1538-7755</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNpVkUFv1DAQhSMEoqXwE0A-cmhazzrjxByQllWhK21LD3C2HNvphsb21s4C-fd4u9uKnmY0896bkb6ieA_0DACbc6CIpRAczy5uliVUJTDEF8UxIGvKukZ8mftHzVHxJqVflNJaIL4ujmYo-KwBOC7SdfDlZTC3d70nq8lt1sGpU_IlmIlcqZTI0hv795Qob8hiGkOWWXIThsmFuFn3yaVPZJ4HYbCGzL0aptQn0sXgyLi22T3a-BBLFsGnEMd-694Wrzo1JPvuUE-Kn18vfiwuy9X3b8vFfFXqqhJjydFU3DQtNVXTcmSguaWN7lilUAmorNBdy1qlKVMUZpYxY7UBCkhbXtcdOynKfW76YzfbVm5i71ScZFC9PIzucmclAuMUs_7zXp83zhpt_RjV8Mz2fOP7tbwNv2V-lwqkOeDjISCG-61No3R90nYYlLdhmyRwwWqgTDRZinupjiGlaLunM0DlDrDcwZM7eDIDllDJHeDs-_D_j0-uR6LsHxGgpHk</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Kane, Eleanor</creator><creator>Skibola, Christine F</creator><creator>Bracci, Paige M</creator><creator>Cerhan, James R</creator><creator>Costas, Laura</creator><creator>Smedby, Karin Ekström</creator><creator>Holly, Elizabeth A</creator><creator>Maynadié, Marc</creator><creator>Novak, Anne J</creator><creator>Lightfoot, Tracy J</creator><creator>Ansell, Stephen M</creator><creator>Smith, Alex G</creator><creator>Liebow, Mark</creator><creator>Melbye, Mads</creator><creator>Morton, Lindsay</creator><creator>de Sanjosé, Silvia</creator><creator>Slager, Susan L</creator><creator>Wang, Sophia S</creator><creator>Zhang, Yawei</creator><creator>Zheng, Tongzhang</creator><creator>Roman, Eve</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20150701</creationdate><title>Non-Hodgkin Lymphoma, Body Mass Index, and Cytokine Polymorphisms: A Pooled Analysis from the InterLymph Consortium</title><author>Kane, Eleanor ; Skibola, Christine F ; Bracci, Paige M ; Cerhan, James R ; Costas, Laura ; Smedby, Karin Ekström ; Holly, Elizabeth A ; Maynadié, Marc ; Novak, Anne J ; Lightfoot, Tracy J ; Ansell, Stephen M ; Smith, Alex G ; Liebow, Mark ; Melbye, Mads ; Morton, Lindsay ; de Sanjosé, Silvia ; Slager, Susan L ; Wang, Sophia S ; Zhang, Yawei ; Zheng, Tongzhang ; Roman, Eve</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-65d46d8b0d48b6531c6e08cf34a5a914e9cfb3bac03a012e33decd10150b677f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adiposity - genetics</topic><topic>Adult</topic><topic>Aged</topic><topic>Body Mass Index</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>DNA, Neoplasm - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Lymphangiogenesis - genetics</topic><topic>Lymphoma, Large B-Cell, Diffuse - genetics</topic><topic>Lymphoma, Large B-Cell, Diffuse - immunology</topic><topic>Lymphoma, Large B-Cell, Diffuse - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kane, Eleanor</creatorcontrib><creatorcontrib>Skibola, Christine F</creatorcontrib><creatorcontrib>Bracci, Paige M</creatorcontrib><creatorcontrib>Cerhan, James R</creatorcontrib><creatorcontrib>Costas, Laura</creatorcontrib><creatorcontrib>Smedby, Karin Ekström</creatorcontrib><creatorcontrib>Holly, Elizabeth A</creatorcontrib><creatorcontrib>Maynadié, Marc</creatorcontrib><creatorcontrib>Novak, Anne J</creatorcontrib><creatorcontrib>Lightfoot, Tracy J</creatorcontrib><creatorcontrib>Ansell, Stephen M</creatorcontrib><creatorcontrib>Smith, Alex G</creatorcontrib><creatorcontrib>Liebow, Mark</creatorcontrib><creatorcontrib>Melbye, Mads</creatorcontrib><creatorcontrib>Morton, Lindsay</creatorcontrib><creatorcontrib>de Sanjosé, Silvia</creatorcontrib><creatorcontrib>Slager, Susan L</creatorcontrib><creatorcontrib>Wang, Sophia S</creatorcontrib><creatorcontrib>Zhang, Yawei</creatorcontrib><creatorcontrib>Zheng, Tongzhang</creatorcontrib><creatorcontrib>Roman, Eve</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kane, Eleanor</au><au>Skibola, Christine F</au><au>Bracci, Paige M</au><au>Cerhan, James R</au><au>Costas, Laura</au><au>Smedby, Karin Ekström</au><au>Holly, Elizabeth A</au><au>Maynadié, Marc</au><au>Novak, Anne J</au><au>Lightfoot, Tracy J</au><au>Ansell, Stephen M</au><au>Smith, Alex G</au><au>Liebow, Mark</au><au>Melbye, Mads</au><au>Morton, Lindsay</au><au>de Sanjosé, Silvia</au><au>Slager, Susan L</au><au>Wang, Sophia S</au><au>Zhang, Yawei</au><au>Zheng, Tongzhang</au><au>Roman, Eve</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-Hodgkin Lymphoma, Body Mass Index, and Cytokine Polymorphisms: A Pooled Analysis from the InterLymph Consortium</atitle><jtitle>CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>24</volume><issue>7</issue><spage>1061</spage><epage>1070</epage><pages>1061-1070</pages><issn>1055-9965</issn><issn>1538-7755</issn><eissn>1538-7755</eissn><abstract>Excess adiposity has been associated with lymphomagenesis, possibly mediated by increased cytokine production causing a chronic inflammatory state. The relationship between obesity, cytokine polymorphisms, and selected mature B-cell neoplasms is reported.
Data on 4,979 cases and 4,752 controls from nine American/European studies from the InterLymph consortium (1988-2008) were pooled. For diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), joint associations of body mass index (from self-reported height and weight) and 12 polymorphisms in cytokines IL1A (rs1800587), IL1B (rs16944, rs1143627), IL1RN (rs454078), IL2 (rs2069762), IL6 (rs1800795, rs1800797), IL10 (rs1800890, rs1800896), TNF (rs1800629), LTA (rs909253), and CARD15 (rs2066847) were investigated using unconditional logistic regression. BMI-polymorphism interaction effects were estimated using the relative excess risk due to interaction (RERI).
Obesity (BMI ≥ 30 kg/m(2)) was associated with DLBCL risk [OR = 1.33; 95% confidence interval (CI), 1.02-1.73], as was TNF-308GA+AA (OR = 1.24; 95% CI, 1.07-1.44). Together, being obese and TNF-308GA+AA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95% CI, 1.27-2.94), with a RERI of 0.41 (95% CI, -0.05-0.84; Pinteraction = 0.13). For FL and CLL/SLL, no associations with obesity or TNF-308GA+AA, either singly or jointly, were observed. No evidence of interactions between obesity and the other polymorphisms were detected.
Our results suggest that cytokine polymorphisms do not generally interact with BMI to increase lymphoma risk but obesity and TNF-308GA+AA may interact to increase DLBCL risk.
Studies using better measures of adiposity are needed to further investigate the interactions between obesity and TNF-308G>A in the pathogenesis of lymphoma.</abstract><cop>United States</cop><pmid>25962811</pmid><doi>10.1158/1055-9965.EPI-14-1355</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online |
| subjects | Adiposity - genetics Adult Aged Body Mass Index Cytokines - genetics Cytokines - metabolism DNA, Neoplasm - genetics Female Genetic Predisposition to Disease Humans Lymphangiogenesis - genetics Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - immunology Lymphoma, Large B-Cell, Diffuse - metabolism Male Middle Aged Polymorphism, Genetic Retrospective Studies Risk Factors Young Adult |
| title | Non-Hodgkin Lymphoma, Body Mass Index, and Cytokine Polymorphisms: A Pooled Analysis from the InterLymph Consortium |
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