Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial

Summary Background Adjuvant endocrine therapy compromises bone health in patients with breast cancer, causing osteopenia, osteoporosis, and fractures. Antiresorptive treatments such as bisphosphonates prevent and counteract these side-effects. In this trial, we aimed to investigate the effects of th...

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Veröffentlicht in:	The Lancet (British edition) 2015-08, Vol.386 (9992), p.433-443
Hauptverfasser:	Gnant, Michael, Prof, Pfeiler, Georg, MD, Dubsky, Peter C, MD, Hubalek, Michael, MD, Greil, Richard, Prof, Jakesz, Raimund, Prof, Wette, Viktor, MD, Balic, Marija, MD, Haslbauer, Ferdinand, MD, Melbinger, Elisabeth, MD, Bjelic-Radisic, Vesna, MD, Artner-Matuschek, Silvia, MD, Fitzal, Florian, MD, Marth, Christian, Prof, Sevelda, Paul, MD, Mlineritsch, Brigitte, MD, Steger, Günther G, MD, Manfreda, Diether, MD, Exner, Ruth, MD, Egle, Daniel, MD, Bergh, Jonas, Prof, Kainberger, Franz, MD, Talbot, Susan, MSc, Warner, Douglas, MD, Fesl, Christian, PhD, Singer, Christian F, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Adult Aged Aged, 80 and over Antibodies, Monoclonal, Humanized - therapeutic use Aromatase Inhibitors - therapeutic use Austria Bisphosphonates Bone density Bone Density - physiology Bone mineral density Breast cancer Breast Neoplasms - complications Breast Neoplasms - drug therapy Cancer therapies Clinical medicine Clinical trials Denosumab Double-Blind Method Endocrine therapy Female Fractures Fractures, Bone - complications Fractures, Bone - prevention & control Humans Internal Medicine Ligands Metastasis Middle Aged Osteoporosis Postmenopause Prospective Studies Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Risk reduction Sensitivity analysis Side effects Studies Sweden Treatment Outcome Womens health
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