Quantification of severe liver iron overload using MRI offset echoes

Quantification of severe liver iron overload using MRI offset echoes

Magnetic resonance imaging (MRI) has become the clinical standard to estimate liver iron overload. The most commonly used method is to measure the transversal relaxation time, T2*, from a multi gradient recalled echo sequence (MGRE). While this technique is reliable in low to moderate liver iron con...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:ACTA RADIOLOGICA OPEN 2015-05, Vol.4 (5), p.2047981614568910
Hauptverfasser: Rydén, Henric, Skorpil, Mikael
Format: Artikel
Sprache:eng
Schlagworte:
Case Report
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 5
container_start_page 2047981614568910
container_title ACTA RADIOLOGICA OPEN
container_volume 4
creator Rydén, Henric
Skorpil, Mikael
description Magnetic resonance imaging (MRI) has become the clinical standard to estimate liver iron overload. The most commonly used method is to measure the transversal relaxation time, T2*, from a multi gradient recalled echo sequence (MGRE). While this technique is reliable in low to moderate liver iron concentrations (LIC), it will be inaccurate when it is severe. We report a case with severe liver hemochromatosis and show the benefit of using an easily implemented MRI offset echo sequence to more accurately estimate LIC. After adjusting treatment, both Ferritin and LIC decreased. Using standard MGRE this reduction could not have been detected.
doi_str_mv 10.1177/2047981614568910
format Article
fullrecord <record><control><sourceid>sage_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_512885</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_2047981614568910</sage_id><sourcerecordid>10.1177_2047981614568910</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-b000df57899832b463086e1fba06a9b7f93de9f8914379f5c280a2f18c71dcd23</originalsourceid><addsrcrecordid>eNp1UctKAzEUDaLYUrt3JfMDo0kmz40g9VWoiKLrkMkkbep0UibTin9vSqu0gqt7uPecc18AnCN4iRDnVxgSLgViiFAmJIJHoI8hFTlhEB3v4R4YxjiHECZiwSg6BT3MIIOUsz64fVnppvPOG9350GTBZdGubWuz2qeQ-XaTTKgOuspW0TfT7Ol1nHgu2i6zZhZsPAMnTtfRDndxAN7v795Gj_nk-WE8upnkpmCyy8s0Q-UoF1KKApeEFVAwi1ypIdOy5E4WlZUu7UIKLh01WECNHRKGo8pUuBiAfOsbP-1yVapl6xe6_VJBe7VLfSRkFUVYCJr411t-qixsZWzTtbo-kB1WGj9T07BWhBCG8cYAbg1MG2JsrfvVIqg2T1B_n5AkF_s9fwU_J99bQk-tmodV26Sb_W_4DSMqj-w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Quantification of severe liver iron overload using MRI offset echoes</title><source>DOAJ Directory of Open Access Journals</source><source>Sage Journals GOLD Open Access 2024</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><source>PubMed Central Open Access</source><creator>Rydén, Henric ; Skorpil, Mikael</creator><creatorcontrib>Rydén, Henric ; Skorpil, Mikael</creatorcontrib><description>Magnetic resonance imaging (MRI) has become the clinical standard to estimate liver iron overload. The most commonly used method is to measure the transversal relaxation time, T2*, from a multi gradient recalled echo sequence (MGRE). While this technique is reliable in low to moderate liver iron concentrations (LIC), it will be inaccurate when it is severe. We report a case with severe liver hemochromatosis and show the benefit of using an easily implemented MRI offset echo sequence to more accurately estimate LIC. After adjusting treatment, both Ferritin and LIC decreased. Using standard MGRE this reduction could not have been detected.</description><identifier>ISSN: 2058-4601</identifier><identifier>EISSN: 2058-4601</identifier><identifier>DOI: 10.1177/2047981614568910</identifier><identifier>PMID: 26060576</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Case Report</subject><ispartof>ACTA RADIOLOGICA OPEN, 2015-05, Vol.4 (5), p.2047981614568910</ispartof><rights>The Foundation Acta Radiologica 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><rights>The Foundation Acta Radiologica 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav 2015 The Foundation Acta Radiologica</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-b000df57899832b463086e1fba06a9b7f93de9f8914379f5c280a2f18c71dcd23</citedby><cites>FETCH-LOGICAL-c369t-b000df57899832b463086e1fba06a9b7f93de9f8914379f5c280a2f18c71dcd23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446225/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446225/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,21945,27830,27901,27902,44921,45309,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26060576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:226060576$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Rydén, Henric</creatorcontrib><creatorcontrib>Skorpil, Mikael</creatorcontrib><title>Quantification of severe liver iron overload using MRI offset echoes</title><title>ACTA RADIOLOGICA OPEN</title><addtitle>Acta Radiol Open</addtitle><description>Magnetic resonance imaging (MRI) has become the clinical standard to estimate liver iron overload. The most commonly used method is to measure the transversal relaxation time, T2*, from a multi gradient recalled echo sequence (MGRE). While this technique is reliable in low to moderate liver iron concentrations (LIC), it will be inaccurate when it is severe. We report a case with severe liver hemochromatosis and show the benefit of using an easily implemented MRI offset echo sequence to more accurately estimate LIC. After adjusting treatment, both Ferritin and LIC decreased. Using standard MGRE this reduction could not have been detected.</description><subject>Case Report</subject><issn>2058-4601</issn><issn>2058-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>D8T</sourceid><recordid>eNp1UctKAzEUDaLYUrt3JfMDo0kmz40g9VWoiKLrkMkkbep0UibTin9vSqu0gqt7uPecc18AnCN4iRDnVxgSLgViiFAmJIJHoI8hFTlhEB3v4R4YxjiHECZiwSg6BT3MIIOUsz64fVnppvPOG9350GTBZdGubWuz2qeQ-XaTTKgOuspW0TfT7Ol1nHgu2i6zZhZsPAMnTtfRDndxAN7v795Gj_nk-WE8upnkpmCyy8s0Q-UoF1KKApeEFVAwi1ypIdOy5E4WlZUu7UIKLh01WECNHRKGo8pUuBiAfOsbP-1yVapl6xe6_VJBe7VLfSRkFUVYCJr411t-qixsZWzTtbo-kB1WGj9T07BWhBCG8cYAbg1MG2JsrfvVIqg2T1B_n5AkF_s9fwU_J99bQk-tmodV26Sb_W_4DSMqj-w</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Rydén, Henric</creator><creator>Skorpil, Mikael</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>ADTPV</scope><scope>BZJLE</scope><scope>D8T</scope><scope>STUKM</scope></search><sort><creationdate>20150501</creationdate><title>Quantification of severe liver iron overload using MRI offset echoes</title><author>Rydén, Henric ; Skorpil, Mikael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-b000df57899832b463086e1fba06a9b7f93de9f8914379f5c280a2f18c71dcd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Case Report</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rydén, Henric</creatorcontrib><creatorcontrib>Skorpil, Mikael</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Other</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Other full text</collection><jtitle>ACTA RADIOLOGICA OPEN</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rydén, Henric</au><au>Skorpil, Mikael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of severe liver iron overload using MRI offset echoes</atitle><jtitle>ACTA RADIOLOGICA OPEN</jtitle><addtitle>Acta Radiol Open</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>4</volume><issue>5</issue><spage>2047981614568910</spage><pages>2047981614568910-</pages><issn>2058-4601</issn><eissn>2058-4601</eissn><abstract>Magnetic resonance imaging (MRI) has become the clinical standard to estimate liver iron overload. The most commonly used method is to measure the transversal relaxation time, T2*, from a multi gradient recalled echo sequence (MGRE). While this technique is reliable in low to moderate liver iron concentrations (LIC), it will be inaccurate when it is severe. We report a case with severe liver hemochromatosis and show the benefit of using an easily implemented MRI offset echo sequence to more accurately estimate LIC. After adjusting treatment, both Ferritin and LIC decreased. Using standard MGRE this reduction could not have been detected.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>26060576</pmid><doi>10.1177/2047981614568910</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2058-4601
ispartof ACTA RADIOLOGICA OPEN, 2015-05, Vol.4 (5), p.2047981614568910
issn 2058-4601
2058-4601
language eng
recordid cdi_swepub_primary_oai_swepub_ki_se_512885
source DOAJ Directory of Open Access Journals; Sage Journals GOLD Open Access 2024; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; PubMed Central Open Access
subjects Case Report
title Quantification of severe liver iron overload using MRI offset echoes
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T06%3A47%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-sage_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Quantification%20of%20severe%20liver%20iron%20overload%20using%20MRI%20offset%20echoes&rft.jtitle=ACTA%20RADIOLOGICA%20OPEN&rft.au=Ryd%C3%A9n,%20Henric&rft.date=2015-05-01&rft.volume=4&rft.issue=5&rft.spage=2047981614568910&rft.pages=2047981614568910-&rft.issn=2058-4601&rft.eissn=2058-4601&rft_id=info:doi/10.1177/2047981614568910&rft_dat=%3Csage_swepu%3E10.1177_2047981614568910%3C/sage_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/26060576&rft_sage_id=10.1177_2047981614568910&rfr_iscdi=true