Protracted brain development in a rodent model of extreme longevity

Extreme longevity requires the continuous and large-scale adaptation of organ systems to delay senescence. Naked mole rats are the longest-living rodents, whose nervous system likely undergoes life-long adaptive reorganization. Nevertheless, neither the cellular organization of their cerebral cortex...

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Veröffentlicht in:	Scientific reports 2015-06, Vol.5 (1), p.11592-11592, Article 11592
Hauptverfasser:	Penz, Orsolya K., Fuzik, Janos, Kurek, Aleksandra B., Romanov, Roman, Larson, John, Park, Thomas J., Harkany, Tibor, Keimpema, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 631/136/368/2431 631/378/2571/1696 631/378/368/2431 9/74 Animals Animals, Newborn Apoptosis Biophysical Phenomena Brain Brain - growth & development CA1 Region, Hippocampal - physiology Cell migration Cell Proliferation Cerebral cortex Dendrites - physiology Dentate Gyrus - physiology Excitability Hippocampus Humanities and Social Sciences Hypoxia Life span Longevity Longevity - physiology Male Mice, Inbred C57BL Models, Biological Mole Rats Morphogenesis multidisciplinary Nervous system Neurogenesis Neuronal Plasticity Neurons - cytology Neuroplasticity Piriform Cortex - physiology Rodents Science Senescence Synapses Synapses - physiology
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