Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial
Dietary nitrate, which is in green leafy vegetables and beetroot, decreases blood pressure through the enterosalivary nitrate-nitrite-nitric oxide pathway in healthy individuals. Whether similar effects would occur in individuals with treated hypertension and, therefore, at increased risk of cardiov...
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| Veröffentlicht in: | The American journal of clinical nutrition 2015-08, Vol.102 (2), p.368-375 |
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| creator | Bondonno, Catherine P Liu, Alex H Croft, Kevin D Ward, Natalie C Shinde, Sujata Moodley, Yuben Lundberg, Jon O Puddey, Ian B Woodman, Richard J Hodgson, Jonathan M |
| description | Dietary nitrate, which is in green leafy vegetables and beetroot, decreases blood pressure through the enterosalivary nitrate-nitrite-nitric oxide pathway in healthy individuals. Whether similar effects would occur in individuals with treated hypertension and, therefore, at increased risk of cardiovascular disease is unclear.
We assessed whether increased dietary nitrate intake by using beetroot juice for 1 wk lowers blood pressure in treated hypertensive men and women.
Participants (n = 27) were recruited to a randomized, placebo-controlled, double-blind crossover trial. The effect of 1-wk intake of nitrate-rich beetroot juice was compared with 1-wk intake of nitrate-depleted beetroot juice (placebo). The primary outcome was blood pressure assessed by measuring home blood pressure during the intervention and 24-h ambulatory blood pressure on day 7 of the intervention. Other outcomes included nitrate metabolism assessed by measuring nitrate and nitrite in plasma, saliva, and urine.
Relative to the placebo, 1-wk intake of nitrate-rich beetroot juice resulted in a 3-fold increase in plasma nitrite and nitrate, a 7-fold increase in salivary nitrite, an 8-fold higher salivary nitrate, and a 4-fold increase in both urinary nitrite and nitrate (P < 0.001). However, no differences in home blood pressure and 24-h ambulatory blood pressure were observed with 1-wk intake of nitrate-rich beetroot juice in comparison with the placebo.
An increase in dietary nitrate intake may not be an effective short-term approach to further lower blood pressure in treated hypertensive subjects. |
| doi_str_mv | 10.3945/ajcn.114.101188 |
| format | Article |
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We assessed whether increased dietary nitrate intake by using beetroot juice for 1 wk lowers blood pressure in treated hypertensive men and women.
Participants (n = 27) were recruited to a randomized, placebo-controlled, double-blind crossover trial. The effect of 1-wk intake of nitrate-rich beetroot juice was compared with 1-wk intake of nitrate-depleted beetroot juice (placebo). The primary outcome was blood pressure assessed by measuring home blood pressure during the intervention and 24-h ambulatory blood pressure on day 7 of the intervention. Other outcomes included nitrate metabolism assessed by measuring nitrate and nitrite in plasma, saliva, and urine.
Relative to the placebo, 1-wk intake of nitrate-rich beetroot juice resulted in a 3-fold increase in plasma nitrite and nitrate, a 7-fold increase in salivary nitrite, an 8-fold higher salivary nitrate, and a 4-fold increase in both urinary nitrite and nitrate (P < 0.001). However, no differences in home blood pressure and 24-h ambulatory blood pressure were observed with 1-wk intake of nitrate-rich beetroot juice in comparison with the placebo.
An increase in dietary nitrate intake may not be an effective short-term approach to further lower blood pressure in treated hypertensive subjects.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.3945/ajcn.114.101188</identifier><identifier>PMID: 26135348</identifier><language>eng</language><publisher>United States: American Society for Clinical Nutrition, Inc</publisher><subject>Aged ; Antihypertensive Agents - therapeutic use ; Beta vulgaris - chemistry ; Beverages - analysis ; Blood pressure ; Cardiovascular disease ; Combined Modality Therapy ; Cross-Over Studies ; Diet ; Double-Blind Method ; Drug Resistance ; Drug Resistance, Multiple ; Drug Therapy, Combination ; Effects ; Female ; Fruit juices ; Humans ; Hypertension - diet therapy ; Hypertension - drug therapy ; Male ; Middle Aged ; Nitrates - analysis ; Nitrates - therapeutic use ; Nitrates - urine ; Nitrites - analysis ; Nitrites - blood ; Nitrites - urine ; Plant Roots - chemistry ; Saliva - chemistry ; Vegetables ; Western Australia</subject><ispartof>The American journal of clinical nutrition, 2015-08, Vol.102 (2), p.368-375</ispartof><rights>2015 American Society for Nutrition.</rights><rights>Copyright American Society for Clinical Nutrition, Inc. Aug 1, 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-57992675f94eefb0f1c6c404838f0bd2b9fc751500c7359c8f9343d3e28037143</citedby><cites>FETCH-LOGICAL-c404t-57992675f94eefb0f1c6c404838f0bd2b9fc751500c7359c8f9343d3e28037143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26135348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:131723970$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Bondonno, Catherine P</creatorcontrib><creatorcontrib>Liu, Alex H</creatorcontrib><creatorcontrib>Croft, Kevin D</creatorcontrib><creatorcontrib>Ward, Natalie C</creatorcontrib><creatorcontrib>Shinde, Sujata</creatorcontrib><creatorcontrib>Moodley, Yuben</creatorcontrib><creatorcontrib>Lundberg, Jon O</creatorcontrib><creatorcontrib>Puddey, Ian B</creatorcontrib><creatorcontrib>Woodman, Richard J</creatorcontrib><creatorcontrib>Hodgson, Jonathan M</creatorcontrib><title>Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Dietary nitrate, which is in green leafy vegetables and beetroot, decreases blood pressure through the enterosalivary nitrate-nitrite-nitric oxide pathway in healthy individuals. Whether similar effects would occur in individuals with treated hypertension and, therefore, at increased risk of cardiovascular disease is unclear.
We assessed whether increased dietary nitrate intake by using beetroot juice for 1 wk lowers blood pressure in treated hypertensive men and women.
Participants (n = 27) were recruited to a randomized, placebo-controlled, double-blind crossover trial. The effect of 1-wk intake of nitrate-rich beetroot juice was compared with 1-wk intake of nitrate-depleted beetroot juice (placebo). The primary outcome was blood pressure assessed by measuring home blood pressure during the intervention and 24-h ambulatory blood pressure on day 7 of the intervention. Other outcomes included nitrate metabolism assessed by measuring nitrate and nitrite in plasma, saliva, and urine.
Relative to the placebo, 1-wk intake of nitrate-rich beetroot juice resulted in a 3-fold increase in plasma nitrite and nitrate, a 7-fold increase in salivary nitrite, an 8-fold higher salivary nitrate, and a 4-fold increase in both urinary nitrite and nitrate (P < 0.001). However, no differences in home blood pressure and 24-h ambulatory blood pressure were observed with 1-wk intake of nitrate-rich beetroot juice in comparison with the placebo.
An increase in dietary nitrate intake may not be an effective short-term approach to further lower blood pressure in treated hypertensive subjects.</description><subject>Aged</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Beta vulgaris - chemistry</subject><subject>Beverages - analysis</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Combined Modality Therapy</subject><subject>Cross-Over Studies</subject><subject>Diet</subject><subject>Double-Blind Method</subject><subject>Drug Resistance</subject><subject>Drug Resistance, Multiple</subject><subject>Drug Therapy, Combination</subject><subject>Effects</subject><subject>Female</subject><subject>Fruit juices</subject><subject>Humans</subject><subject>Hypertension - diet therapy</subject><subject>Hypertension - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitrates - analysis</subject><subject>Nitrates - therapeutic use</subject><subject>Nitrates - urine</subject><subject>Nitrites - analysis</subject><subject>Nitrites - blood</subject><subject>Nitrites - urine</subject><subject>Plant Roots - chemistry</subject><subject>Saliva - chemistry</subject><subject>Vegetables</subject><subject>Western Australia</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNpdkU1v1DAQhi0EokvhzA1Z4sIlW38lsblVFV9SJS5wthxnzHqb2MF2isrv4AfjaJceOHk8fubVWA9CrynZcyXaK3O0YU-p2FNCqZRP0I4qLhvOSP8U7QghrFG0ay_Qi5yPhFAmZPccXbCO8pYLuUN_rocMwQKODpuAwTmwZbsc_I8DDr4kUwD7UMwdYJfijAeAkmIs-Lj6bS7gYYpxxEuCnNe0wbgkqGMjPjwskAqE7O-3_ujv_biaKb_HBicTxjj73xWzMdTIaaplSd5ML9EzVyl4dT4v0fePH77dfG5uv376cnN921hBRGnaXinW9a1TAsANxFHbbS-SS0eGkQ3K2b6lLSG2562y0iku-MiBScJ7Kvglak65-Rcs66CX5GeTHnQ0Xp9bd7UC3VLG2ca_O_FLij9XyEXPPluYJhMgrlnTnlBZtQha0bf_oce4plB_s1FM9qIjrFJXJ8qmmHMC97gCJXoTrDfBugrWJ8F14s05dx1mGB_5f0b5X4_co28</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Bondonno, Catherine P</creator><creator>Liu, Alex H</creator><creator>Croft, Kevin D</creator><creator>Ward, Natalie C</creator><creator>Shinde, Sujata</creator><creator>Moodley, Yuben</creator><creator>Lundberg, Jon O</creator><creator>Puddey, Ian B</creator><creator>Woodman, Richard J</creator><creator>Hodgson, Jonathan M</creator><general>American Society for Clinical Nutrition, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20150801</creationdate><title>Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial</title><author>Bondonno, Catherine P ; Liu, Alex H ; Croft, Kevin D ; Ward, Natalie C ; Shinde, Sujata ; Moodley, Yuben ; Lundberg, Jon O ; Puddey, Ian B ; Woodman, Richard J ; Hodgson, Jonathan M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-57992675f94eefb0f1c6c404838f0bd2b9fc751500c7359c8f9343d3e28037143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Beta vulgaris - chemistry</topic><topic>Beverages - analysis</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Combined Modality Therapy</topic><topic>Cross-Over Studies</topic><topic>Diet</topic><topic>Double-Blind Method</topic><topic>Drug Resistance</topic><topic>Drug Resistance, Multiple</topic><topic>Drug Therapy, Combination</topic><topic>Effects</topic><topic>Female</topic><topic>Fruit juices</topic><topic>Humans</topic><topic>Hypertension - diet therapy</topic><topic>Hypertension - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitrates - analysis</topic><topic>Nitrates - therapeutic use</topic><topic>Nitrates - urine</topic><topic>Nitrites - analysis</topic><topic>Nitrites - blood</topic><topic>Nitrites - urine</topic><topic>Plant Roots - chemistry</topic><topic>Saliva - chemistry</topic><topic>Vegetables</topic><topic>Western Australia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bondonno, Catherine P</creatorcontrib><creatorcontrib>Liu, Alex H</creatorcontrib><creatorcontrib>Croft, Kevin D</creatorcontrib><creatorcontrib>Ward, Natalie C</creatorcontrib><creatorcontrib>Shinde, Sujata</creatorcontrib><creatorcontrib>Moodley, Yuben</creatorcontrib><creatorcontrib>Lundberg, Jon O</creatorcontrib><creatorcontrib>Puddey, Ian B</creatorcontrib><creatorcontrib>Woodman, Richard J</creatorcontrib><creatorcontrib>Hodgson, Jonathan M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bondonno, Catherine P</au><au>Liu, Alex H</au><au>Croft, Kevin D</au><au>Ward, Natalie C</au><au>Shinde, Sujata</au><au>Moodley, Yuben</au><au>Lundberg, Jon O</au><au>Puddey, Ian B</au><au>Woodman, Richard J</au><au>Hodgson, Jonathan M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>102</volume><issue>2</issue><spage>368</spage><epage>375</epage><pages>368-375</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>Dietary nitrate, which is in green leafy vegetables and beetroot, decreases blood pressure through the enterosalivary nitrate-nitrite-nitric oxide pathway in healthy individuals. Whether similar effects would occur in individuals with treated hypertension and, therefore, at increased risk of cardiovascular disease is unclear.
We assessed whether increased dietary nitrate intake by using beetroot juice for 1 wk lowers blood pressure in treated hypertensive men and women.
Participants (n = 27) were recruited to a randomized, placebo-controlled, double-blind crossover trial. The effect of 1-wk intake of nitrate-rich beetroot juice was compared with 1-wk intake of nitrate-depleted beetroot juice (placebo). The primary outcome was blood pressure assessed by measuring home blood pressure during the intervention and 24-h ambulatory blood pressure on day 7 of the intervention. Other outcomes included nitrate metabolism assessed by measuring nitrate and nitrite in plasma, saliva, and urine.
Relative to the placebo, 1-wk intake of nitrate-rich beetroot juice resulted in a 3-fold increase in plasma nitrite and nitrate, a 7-fold increase in salivary nitrite, an 8-fold higher salivary nitrate, and a 4-fold increase in both urinary nitrite and nitrate (P < 0.001). However, no differences in home blood pressure and 24-h ambulatory blood pressure were observed with 1-wk intake of nitrate-rich beetroot juice in comparison with the placebo.
An increase in dietary nitrate intake may not be an effective short-term approach to further lower blood pressure in treated hypertensive subjects.</abstract><cop>United States</cop><pub>American Society for Clinical Nutrition, Inc</pub><pmid>26135348</pmid><doi>10.3945/ajcn.114.101188</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Antihypertensive Agents - therapeutic use Beta vulgaris - chemistry Beverages - analysis Blood pressure Cardiovascular disease Combined Modality Therapy Cross-Over Studies Diet Double-Blind Method Drug Resistance Drug Resistance, Multiple Drug Therapy, Combination Effects Female Fruit juices Humans Hypertension - diet therapy Hypertension - drug therapy Male Middle Aged Nitrates - analysis Nitrates - therapeutic use Nitrates - urine Nitrites - analysis Nitrites - blood Nitrites - urine Plant Roots - chemistry Saliva - chemistry Vegetables Western Australia |
| title | Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial |
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