Purinergic signaling in Parkinson's disease. Relevance for treatment

Purinergic signaling modulates dopaminergic neurotransmission in health and disease. Classically adenosine A1 and A2A receptors have been considered key for the fine tune control of dopamine actions in the striatum, the main CNS motor control center. The main adenosine signaling mechanism is via the...

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Veröffentlicht in:	Neuropharmacology 2016-05, Vol.104, p.161-168
Hauptverfasser:	Navarro, Gemma, Borroto-Escuela, Dasiel O., Fuxe, Kjell, Franco, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - metabolism Adenosine A2 Receptor Antagonists - metabolism Adenosine receptor antagonist Adenosine receptors Animals ATP receptors Basal Ganglia - metabolism Corpus Striatum - metabolism GPCR heteromer Humans Medicin och hälsovetenskap Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson's disease Purine Nucleotides - metabolism Purines - therapeutic use Pyrimidines - therapeutic use Receptor, Adenosine A2A - metabolism Receptors, Dopamine D2 - metabolism Signal Transduction Triazoles - therapeutic use
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