Maternal folate status as a risk factor for autism spectrum disorders: a review of existing evidence
Emerging evidence from epidemiological studies supports the notion that maternal folate status regulated by dietary and genetic factors early in pregnancy may influence the risk of autism spectrum disorders (ASD). In this review, we provide an overview of what is known about the role of folate in th...
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| Veröffentlicht in: | British journal of nutrition 2015-09, Vol.114 (5), p.663-672 |
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| creator | DeVilbiss, Elizabeth A. Gardner, Renee M. Newschaffer, Craig J. Lee, Brian K. |
| description | Emerging evidence from epidemiological studies supports the notion that maternal folate status regulated by dietary and genetic factors early in pregnancy may influence the risk of autism spectrum disorders (ASD). In this review, we provide an overview of what is known about the role of folate in the aetiology of neurodevelopmental disorders; summarise relevant biological, genetic and epigenetic mechanisms; and synthesise the evidence from human observational studies and randomised controlled trials that have examined the relationship between maternal folate and ASD or related traits. Much of the existing literature on this topic is subject to limitations such as potential confounding by healthy behaviours and other dietary factors, and exposure assessed within limited exposure windows. As the existing evidence is inconclusive, further research remains to be conducted in order to verify this hypothesis. Complete assessment of maternal functional folate status through the pre- and peri-conceptional periods requires biological measurement of folate, vitamin B12 and homocysteine and genetic variants involved in one-carbon metabolism and epigenetic mechanisms. In addition to more complete assessment of maternal functional folate status, careful consideration of potential confounding is warranted. |
| doi_str_mv | 10.1017/S0007114515002470 |
| format | Article |
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In this review, we provide an overview of what is known about the role of folate in the aetiology of neurodevelopmental disorders; summarise relevant biological, genetic and epigenetic mechanisms; and synthesise the evidence from human observational studies and randomised controlled trials that have examined the relationship between maternal folate and ASD or related traits. Much of the existing literature on this topic is subject to limitations such as potential confounding by healthy behaviours and other dietary factors, and exposure assessed within limited exposure windows. As the existing evidence is inconclusive, further research remains to be conducted in order to verify this hypothesis. Complete assessment of maternal functional folate status through the pre- and peri-conceptional periods requires biological measurement of folate, vitamin B12 and homocysteine and genetic variants involved in one-carbon metabolism and epigenetic mechanisms. In addition to more complete assessment of maternal functional folate status, careful consideration of potential confounding is warranted.</description><identifier>ISSN: 0007-1145</identifier><identifier>ISSN: 1475-2662</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114515002470</identifier><identifier>PMID: 26243379</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Autism ; Child Development Disorders, Pervasive - blood ; Child Development Disorders, Pervasive - etiology ; DNA Methylation ; Epidemiology ; Epigenetics ; Female ; Folic Acid - blood ; Folic Acid Deficiency - blood ; Folic Acid Deficiency - complications ; Genetic factors ; Genetic variance ; Humans ; Maternal & child health ; Medicin och hälsovetenskap ; Neurological disorders ; Observational studies ; Pregnancy ; Pregnancy Complications - blood ; Review Article ; Risk Factors ; Vitamin B Complex - blood</subject><ispartof>British journal of nutrition, 2015-09, Vol.114 (5), p.663-672</ispartof><rights>Copyright © The Authors 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-daad88affa09c1bd69d9274671768d979ad5ab7164de2295cae5590f2cb15cd3</citedby><cites>FETCH-LOGICAL-c570t-daad88affa09c1bd69d9274671768d979ad5ab7164de2295cae5590f2cb15cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114515002470/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,780,784,885,27924,27925,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26243379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:131873582$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>DeVilbiss, Elizabeth A.</creatorcontrib><creatorcontrib>Gardner, Renee M.</creatorcontrib><creatorcontrib>Newschaffer, Craig J.</creatorcontrib><creatorcontrib>Lee, Brian K.</creatorcontrib><title>Maternal folate status as a risk factor for autism spectrum disorders: a review of existing evidence</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Emerging evidence from epidemiological studies supports the notion that maternal folate status regulated by dietary and genetic factors early in pregnancy may influence the risk of autism spectrum disorders (ASD). In this review, we provide an overview of what is known about the role of folate in the aetiology of neurodevelopmental disorders; summarise relevant biological, genetic and epigenetic mechanisms; and synthesise the evidence from human observational studies and randomised controlled trials that have examined the relationship between maternal folate and ASD or related traits. Much of the existing literature on this topic is subject to limitations such as potential confounding by healthy behaviours and other dietary factors, and exposure assessed within limited exposure windows. As the existing evidence is inconclusive, further research remains to be conducted in order to verify this hypothesis. Complete assessment of maternal functional folate status through the pre- and peri-conceptional periods requires biological measurement of folate, vitamin B12 and homocysteine and genetic variants involved in one-carbon metabolism and epigenetic mechanisms. In addition to more complete assessment of maternal functional folate status, careful consideration of potential confounding is warranted.</description><subject>Autism</subject><subject>Child Development Disorders, Pervasive - blood</subject><subject>Child Development Disorders, Pervasive - etiology</subject><subject>DNA Methylation</subject><subject>Epidemiology</subject><subject>Epigenetics</subject><subject>Female</subject><subject>Folic Acid - blood</subject><subject>Folic Acid Deficiency - blood</subject><subject>Folic Acid Deficiency - complications</subject><subject>Genetic factors</subject><subject>Genetic variance</subject><subject>Humans</subject><subject>Maternal & child health</subject><subject>Medicin och hälsovetenskap</subject><subject>Neurological disorders</subject><subject>Observational studies</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - blood</subject><subject>Review Article</subject><subject>Risk Factors</subject><subject>Vitamin B Complex - 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In this review, we provide an overview of what is known about the role of folate in the aetiology of neurodevelopmental disorders; summarise relevant biological, genetic and epigenetic mechanisms; and synthesise the evidence from human observational studies and randomised controlled trials that have examined the relationship between maternal folate and ASD or related traits. Much of the existing literature on this topic is subject to limitations such as potential confounding by healthy behaviours and other dietary factors, and exposure assessed within limited exposure windows. As the existing evidence is inconclusive, further research remains to be conducted in order to verify this hypothesis. Complete assessment of maternal functional folate status through the pre- and peri-conceptional periods requires biological measurement of folate, vitamin B12 and homocysteine and genetic variants involved in one-carbon metabolism and epigenetic mechanisms. In addition to more complete assessment of maternal functional folate status, careful consideration of potential confounding is warranted.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>26243379</pmid><doi>10.1017/S0007114515002470</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Autism Child Development Disorders, Pervasive - blood Child Development Disorders, Pervasive - etiology DNA Methylation Epidemiology Epigenetics Female Folic Acid - blood Folic Acid Deficiency - blood Folic Acid Deficiency - complications Genetic factors Genetic variance Humans Maternal & child health Medicin och hälsovetenskap Neurological disorders Observational studies Pregnancy Pregnancy Complications - blood Review Article Risk Factors Vitamin B Complex - blood |
| title | Maternal folate status as a risk factor for autism spectrum disorders: a review of existing evidence |
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