Human Mucosa-Associated Invariant T Cells Accumulate in Colon Adenocarcinomas but Produce Reduced Amounts of IFN-γ

Mucosa-associated invariant T (MAIT) cells are innate-like T cells with a conserved TCR α-chain recognizing bacterial metabolites presented on the invariant MHC-related 1 molecule. MAIT cells are present in intestinal tissues and liver, and they rapidly secrete IFN-γ and IL-17 in response to bacteri...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-10, Vol.195 (7), p.3472-3481
Hauptverfasser:	Sundström, Patrik, Ahlmanner, Filip, Akéus, Paulina, Sundquist, Malin, Alsén, Samuel, Yrlid, Ulf, Börjesson, Lars, Sjöling, Åsa, Gustavsson, Bengt, Wong, S B Justin, Quiding-Järbrink, Marianne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Adult Aged Aged, 80 and over Clinical Laboratory Medicine Colonic Neoplasms - pathology Female Granzymes - biosynthesis Humans Inflammation - immunology Interferon-gamma - biosynthesis Interferon-gamma - immunology Interleukin-17 - biosynthesis Interleukin-17 - immunology Interleukin-2 Intestinal Mucosa - cytology Intestinal Mucosa - immunology Kirurgi Klinisk laboratoriemedicin Liver - cytology Liver - immunology Lymphocyte Activation - immunology Male Middle Aged Receptors, CCR - biosynthesis Receptors, CCR6 - biosynthesis Surgery T-Lymphocyte Subsets - immunology T-Lymphocytes - immunology Tumor Necrosis Factor-alpha - biosynthesis
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