Mantle cell lymphoma—a spectrum from indolent to aggressive disease
Mantle cell lymphoma (MCL) is a distinctive lymphoma type generally characterized by the presence of CCND1 translocation and overexpression of cyclin D1. MCL usually presents with advanced stage and rapid clinical progression. The diagnosis is in most instances uncomplicated but cases with variant m...
Gespeichert in:
| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2016-03, Vol.468 (3), p.245-257 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 257 |
|---|---|
| container_issue | 3 |
| container_start_page | 245 |
| container_title | Virchows Archiv : an international journal of pathology |
| container_volume | 468 |
| creator | Sander, Birgitta Quintanilla-Martinez, Leticia Ott, German Xerri, Luc Kuzu, Isinsu Chan, John K. C. Swerdlow, Steven H. Campo, Elias |
| description | Mantle cell lymphoma (MCL) is a distinctive lymphoma type generally characterized by the presence of
CCND1
translocation and overexpression of cyclin D1. MCL usually presents with advanced stage and rapid clinical progression. The diagnosis is in most instances uncomplicated but cases with variant morphologies or immunophenotypes, especially cyclin D1-negative cases, may cause diagnostic difficulties. During the mantle cell lymphoma (MCL) session at the European Association of Haematopathology/Society for Hematopathology workshop 2014 held in Istanbul, Turkey, submitted cases illustrated interesting features such as unusual morphology or immunophenotypes. In several submitted cases of cyclin D1-positive MCL,
CCND1
rearrangement could not be detected by t(11;14)(q13;q32) dual-color dual-fusion FISH but was suggested by
CCND1
break-apart probes, and advantages and disadvantages of different FISH probes were highlighted. Three cyclin D1-negative MCL cases were submitted. These were identified by SOX11 immunohistochemistry and found to carry
CCND2
translocations and/or to express high levels of cyclin D2 mRNA. Features associated with aggressive clinical course were presented including high expression of p53 protein and
MYC
aberrations. The need to integrate histological, immunophenotypic, genetic, and clinical data to arrive at the correct diagnosis was emphasized. |
| doi_str_mv | 10.1007/s00428-015-1840-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_511204</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1777076015</sourcerecordid><originalsourceid>FETCH-LOGICAL-c530t-df22252c388e0daf106f3f08e7097c96a4768ff17c401c44af6ec569c56447e53</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhS1ERYfCA7BBkdiwMb3-j5eoKj9SUTewtlznekhJ4mAnoO54CJ6QJ8GjmRZUqQvLlv2dY_scQl4weMMAzGkBkLylwBRlrQSqH5ENk4JTLsA8JhuwUlEtmDkmT0u5BuCsZfoJOeaa21ZJsSHnn_y0DNgEHIZmuBnnr2n0f3799k2ZMSx5HZuY09j0U5cGnJZmSY3fbjOW0v_ApusL-oLPyFH0Q8Hnh_mEfHl3_vnsA724fP_x7O0FDUrAQrvIOVc8iLZF6HxkoKOI0KIBa4LVXhrdxshMkMCClD5qDErbOqQ0qMQJoXvf8hPn9crNuR99vnHJ9-6w9a2u0CnGOMjK2wf5Oafun-hWyITgLVhrq_b1XlvB7yuWxY192cXkJ0xrccwYA0bX8Cv66h56ndY81SR2VM1aS8UqxfZUyKmUjPHuOQzcrk-379NVS7fr0-mqeXlwXq9G7O4UtwVWgB9-WI-mLeb_rn7Q9S_OIKvM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1776296451</pqid></control><display><type>article</type><title>Mantle cell lymphoma—a spectrum from indolent to aggressive disease</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Sander, Birgitta ; Quintanilla-Martinez, Leticia ; Ott, German ; Xerri, Luc ; Kuzu, Isinsu ; Chan, John K. C. ; Swerdlow, Steven H. ; Campo, Elias</creator><creatorcontrib>Sander, Birgitta ; Quintanilla-Martinez, Leticia ; Ott, German ; Xerri, Luc ; Kuzu, Isinsu ; Chan, John K. C. ; Swerdlow, Steven H. ; Campo, Elias</creatorcontrib><description>Mantle cell lymphoma (MCL) is a distinctive lymphoma type generally characterized by the presence of
CCND1
translocation and overexpression of cyclin D1. MCL usually presents with advanced stage and rapid clinical progression. The diagnosis is in most instances uncomplicated but cases with variant morphologies or immunophenotypes, especially cyclin D1-negative cases, may cause diagnostic difficulties. During the mantle cell lymphoma (MCL) session at the European Association of Haematopathology/Society for Hematopathology workshop 2014 held in Istanbul, Turkey, submitted cases illustrated interesting features such as unusual morphology or immunophenotypes. In several submitted cases of cyclin D1-positive MCL,
CCND1
rearrangement could not be detected by t(11;14)(q13;q32) dual-color dual-fusion FISH but was suggested by
CCND1
break-apart probes, and advantages and disadvantages of different FISH probes were highlighted. Three cyclin D1-negative MCL cases were submitted. These were identified by SOX11 immunohistochemistry and found to carry
CCND2
translocations and/or to express high levels of cyclin D2 mRNA. Features associated with aggressive clinical course were presented including high expression of p53 protein and
MYC
aberrations. The need to integrate histological, immunophenotypic, genetic, and clinical data to arrive at the correct diagnosis was emphasized.</description><identifier>ISSN: 0945-6317</identifier><identifier>ISSN: 1432-2307</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-015-1840-6</identifier><identifier>PMID: 26298543</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Animals ; Humans ; Immunohistochemistry - methods ; Immunophenotyping - methods ; In Situ Hybridization, Fluorescence ; Lymphoma ; Lymphoma, B-Cell - diagnosis ; Lymphoma, B-Cell - genetics ; Lymphoma, B-Cell - pathology ; Lymphoma, Mantle-Cell - pathology ; Medicin och hälsovetenskap ; Medicine ; Medicine & Public Health ; Pathology ; Probes ; Review and Perspectives ; Translocation ; Translocation, Genetic - genetics</subject><ispartof>Virchows Archiv : an international journal of pathology, 2016-03, Vol.468 (3), p.245-257</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-df22252c388e0daf106f3f08e7097c96a4768ff17c401c44af6ec569c56447e53</citedby><cites>FETCH-LOGICAL-c530t-df22252c388e0daf106f3f08e7097c96a4768ff17c401c44af6ec569c56447e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-015-1840-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-015-1840-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,313,314,780,784,792,885,27922,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26298543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:133280999$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Sander, Birgitta</creatorcontrib><creatorcontrib>Quintanilla-Martinez, Leticia</creatorcontrib><creatorcontrib>Ott, German</creatorcontrib><creatorcontrib>Xerri, Luc</creatorcontrib><creatorcontrib>Kuzu, Isinsu</creatorcontrib><creatorcontrib>Chan, John K. C.</creatorcontrib><creatorcontrib>Swerdlow, Steven H.</creatorcontrib><creatorcontrib>Campo, Elias</creatorcontrib><title>Mantle cell lymphoma—a spectrum from indolent to aggressive disease</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>Mantle cell lymphoma (MCL) is a distinctive lymphoma type generally characterized by the presence of
CCND1
translocation and overexpression of cyclin D1. MCL usually presents with advanced stage and rapid clinical progression. The diagnosis is in most instances uncomplicated but cases with variant morphologies or immunophenotypes, especially cyclin D1-negative cases, may cause diagnostic difficulties. During the mantle cell lymphoma (MCL) session at the European Association of Haematopathology/Society for Hematopathology workshop 2014 held in Istanbul, Turkey, submitted cases illustrated interesting features such as unusual morphology or immunophenotypes. In several submitted cases of cyclin D1-positive MCL,
CCND1
rearrangement could not be detected by t(11;14)(q13;q32) dual-color dual-fusion FISH but was suggested by
CCND1
break-apart probes, and advantages and disadvantages of different FISH probes were highlighted. Three cyclin D1-negative MCL cases were submitted. These were identified by SOX11 immunohistochemistry and found to carry
CCND2
translocations and/or to express high levels of cyclin D2 mRNA. Features associated with aggressive clinical course were presented including high expression of p53 protein and
MYC
aberrations. The need to integrate histological, immunophenotypic, genetic, and clinical data to arrive at the correct diagnosis was emphasized.</description><subject>Animals</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>Immunophenotyping - methods</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Lymphoma</subject><subject>Lymphoma, B-Cell - diagnosis</subject><subject>Lymphoma, B-Cell - genetics</subject><subject>Lymphoma, B-Cell - pathology</subject><subject>Lymphoma, Mantle-Cell - pathology</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pathology</subject><subject>Probes</subject><subject>Review and Perspectives</subject><subject>Translocation</subject><subject>Translocation, Genetic - genetics</subject><issn>0945-6317</issn><issn>1432-2307</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1u1DAUhS1ERYfCA7BBkdiwMb3-j5eoKj9SUTewtlznekhJ4mAnoO54CJ6QJ8GjmRZUqQvLlv2dY_scQl4weMMAzGkBkLylwBRlrQSqH5ENk4JTLsA8JhuwUlEtmDkmT0u5BuCsZfoJOeaa21ZJsSHnn_y0DNgEHIZmuBnnr2n0f3799k2ZMSx5HZuY09j0U5cGnJZmSY3fbjOW0v_ApusL-oLPyFH0Q8Hnh_mEfHl3_vnsA724fP_x7O0FDUrAQrvIOVc8iLZF6HxkoKOI0KIBa4LVXhrdxshMkMCClD5qDErbOqQ0qMQJoXvf8hPn9crNuR99vnHJ9-6w9a2u0CnGOMjK2wf5Oafun-hWyITgLVhrq_b1XlvB7yuWxY192cXkJ0xrccwYA0bX8Cv66h56ndY81SR2VM1aS8UqxfZUyKmUjPHuOQzcrk-379NVS7fr0-mqeXlwXq9G7O4UtwVWgB9-WI-mLeb_rn7Q9S_OIKvM</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Sander, Birgitta</creator><creator>Quintanilla-Martinez, Leticia</creator><creator>Ott, German</creator><creator>Xerri, Luc</creator><creator>Kuzu, Isinsu</creator><creator>Chan, John K. C.</creator><creator>Swerdlow, Steven H.</creator><creator>Campo, Elias</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20160301</creationdate><title>Mantle cell lymphoma—a spectrum from indolent to aggressive disease</title><author>Sander, Birgitta ; Quintanilla-Martinez, Leticia ; Ott, German ; Xerri, Luc ; Kuzu, Isinsu ; Chan, John K. C. ; Swerdlow, Steven H. ; Campo, Elias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-df22252c388e0daf106f3f08e7097c96a4768ff17c401c44af6ec569c56447e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>Immunophenotyping - methods</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Lymphoma</topic><topic>Lymphoma, B-Cell - diagnosis</topic><topic>Lymphoma, B-Cell - genetics</topic><topic>Lymphoma, B-Cell - pathology</topic><topic>Lymphoma, Mantle-Cell - pathology</topic><topic>Medicin och hälsovetenskap</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pathology</topic><topic>Probes</topic><topic>Review and Perspectives</topic><topic>Translocation</topic><topic>Translocation, Genetic - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sander, Birgitta</creatorcontrib><creatorcontrib>Quintanilla-Martinez, Leticia</creatorcontrib><creatorcontrib>Ott, German</creatorcontrib><creatorcontrib>Xerri, Luc</creatorcontrib><creatorcontrib>Kuzu, Isinsu</creatorcontrib><creatorcontrib>Chan, John K. C.</creatorcontrib><creatorcontrib>Swerdlow, Steven H.</creatorcontrib><creatorcontrib>Campo, Elias</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sander, Birgitta</au><au>Quintanilla-Martinez, Leticia</au><au>Ott, German</au><au>Xerri, Luc</au><au>Kuzu, Isinsu</au><au>Chan, John K. C.</au><au>Swerdlow, Steven H.</au><au>Campo, Elias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mantle cell lymphoma—a spectrum from indolent to aggressive disease</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>468</volume><issue>3</issue><spage>245</spage><epage>257</epage><pages>245-257</pages><issn>0945-6317</issn><issn>1432-2307</issn><eissn>1432-2307</eissn><abstract>Mantle cell lymphoma (MCL) is a distinctive lymphoma type generally characterized by the presence of
CCND1
translocation and overexpression of cyclin D1. MCL usually presents with advanced stage and rapid clinical progression. The diagnosis is in most instances uncomplicated but cases with variant morphologies or immunophenotypes, especially cyclin D1-negative cases, may cause diagnostic difficulties. During the mantle cell lymphoma (MCL) session at the European Association of Haematopathology/Society for Hematopathology workshop 2014 held in Istanbul, Turkey, submitted cases illustrated interesting features such as unusual morphology or immunophenotypes. In several submitted cases of cyclin D1-positive MCL,
CCND1
rearrangement could not be detected by t(11;14)(q13;q32) dual-color dual-fusion FISH but was suggested by
CCND1
break-apart probes, and advantages and disadvantages of different FISH probes were highlighted. Three cyclin D1-negative MCL cases were submitted. These were identified by SOX11 immunohistochemistry and found to carry
CCND2
translocations and/or to express high levels of cyclin D2 mRNA. Features associated with aggressive clinical course were presented including high expression of p53 protein and
MYC
aberrations. The need to integrate histological, immunophenotypic, genetic, and clinical data to arrive at the correct diagnosis was emphasized.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26298543</pmid><doi>10.1007/s00428-015-1840-6</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0945-6317 |
| ispartof | Virchows Archiv : an international journal of pathology, 2016-03, Vol.468 (3), p.245-257 |
| issn | 0945-6317 1432-2307 1432-2307 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_511204 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Humans Immunohistochemistry - methods Immunophenotyping - methods In Situ Hybridization, Fluorescence Lymphoma Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - genetics Lymphoma, B-Cell - pathology Lymphoma, Mantle-Cell - pathology Medicin och hälsovetenskap Medicine Medicine & Public Health Pathology Probes Review and Perspectives Translocation Translocation, Genetic - genetics |
| title | Mantle cell lymphoma—a spectrum from indolent to aggressive disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A08%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mantle%20cell%20lymphoma%E2%80%94a%20spectrum%20from%20indolent%20to%20aggressive%20disease&rft.jtitle=Virchows%20Archiv%20:%20an%20international%20journal%20of%20pathology&rft.au=Sander,%20Birgitta&rft.date=2016-03-01&rft.volume=468&rft.issue=3&rft.spage=245&rft.epage=257&rft.pages=245-257&rft.issn=0945-6317&rft.eissn=1432-2307&rft_id=info:doi/10.1007/s00428-015-1840-6&rft_dat=%3Cproquest_swepu%3E1777076015%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1776296451&rft_id=info:pmid/26298543&rfr_iscdi=true |