Body size across the life course and prostate cancer in the Health Professionals Follow‐up Study
Current evidence of an association between body size and prostate cancer is conflicting, possibly due to differential effects of body size across the lifespan and the heterogeneity of the disease. We therefore examined childhood and adult body size in relation to total incident prostate cancer and p...
Gespeichert in:
| Veröffentlicht in: | International journal of cancer 2016-02, Vol.138 (4), p.853-865 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 865 |
|---|---|
| container_issue | 4 |
| container_start_page | 853 |
| container_title | International journal of cancer |
| container_volume | 138 |
| creator | Möller, Elisabeth Wilson, Kathryn M. Batista, Julie L. Mucci, Lorelei A. Bälter, Katarina Giovannucci, Edward |
| description | Current evidence of an association between body size and prostate cancer is conflicting, possibly due to differential effects of body size across the lifespan and the heterogeneity of the disease. We therefore examined childhood and adult body size in relation to total incident prostate cancer and prognostic subtypes in a prospective cohort of 47,491 US men in the Health Professionals Follow‐up Study. We assessed adult height, body mass index (BMI) in early and middle‐to‐late adulthood, adult waist circumference, and body shape at age 10. With follow‐up from 1986 to 2010, we estimated the relative risk (RR) of prostate cancer using Cox proportional hazards models. We identified 6,183 incident cases. Tallness was associated with increased risk of advanced‐stage tumors, particularly fatal disease (RR = 1.66, 95% CI 1.23–2.23, highest vs. lowest quintile, ptrend |
| doi_str_mv | 10.1002/ijc.29842 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_510809</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1760910521</sourcerecordid><originalsourceid>FETCH-LOGICAL-j5802-557c577688e5480eeb9aa848e97b73bbea596baef59e84db70fce642c5b095f03</originalsourceid><addsrcrecordid>eNp1ks9u1DAQxi1ERZfCgRdAlrj00LRjJ_6TC1LZUtqqEkj8uVp2Mul6ycZLnHS1nHgEnpEnwd1dKorEyaPv-3n0aWYIecHgmAHwEz-vjnmpC_6ITBiUKgPOxGMySR5kiuVynzyNcQ7AmIDiCdnnMhdCg5wQ9ybUaxr9d6S26kOMdJghbX2DtApjH5Pc1XSZnMEOSbNdhT313Qa7QNsOM_qhDw3G6ENn20jPQ9uG1a8fP8cl_TiM9foZ2WuSgc937wH5fP720_Qiu37_7nJ6ep3NUxSeCaEqoZTUGkWhAdGV1upCY6mcyp1DK0rpLDaiRF3UTkFToSx4JRyUooH8gGTbvnGFy9GZZe8Xtl-bYL3ZSV9ThUYw0FAm_ui__Jn_cmpCf2MW9cwUIKVO-OstntgF1hV2Q2_bB78eOp2fmZtwa9LIeV7I1OBw16AP30aMg1n4WGHb2g7DGA1TEkoGgrOEvvoHnadl3I03UUIJEEzniXr5d6L7KH-2m4CTLbDyLa7vfQbm7mxMOhuzORtzeTXdFPlvI4O3Wg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1757505183</pqid></control><display><type>article</type><title>Body size across the life course and prostate cancer in the Health Professionals Follow‐up Study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SWEPUB Freely available online</source><creator>Möller, Elisabeth ; Wilson, Kathryn M. ; Batista, Julie L. ; Mucci, Lorelei A. ; Bälter, Katarina ; Giovannucci, Edward</creator><creatorcontrib>Möller, Elisabeth ; Wilson, Kathryn M. ; Batista, Julie L. ; Mucci, Lorelei A. ; Bälter, Katarina ; Giovannucci, Edward</creatorcontrib><description>Current evidence of an association between body size and prostate cancer is conflicting, possibly due to differential effects of body size across the lifespan and the heterogeneity of the disease. We therefore examined childhood and adult body size in relation to total incident prostate cancer and prognostic subtypes in a prospective cohort of 47,491 US men in the Health Professionals Follow‐up Study. We assessed adult height, body mass index (BMI) in early and middle‐to‐late adulthood, adult waist circumference, and body shape at age 10. With follow‐up from 1986 to 2010, we estimated the relative risk (RR) of prostate cancer using Cox proportional hazards models. We identified 6,183 incident cases. Tallness was associated with increased risk of advanced‐stage tumors, particularly fatal disease (RR = 1.66, 95% CI 1.23–2.23, highest vs. lowest quintile, ptrend < 0.001). High BMI at age 21 was inversely associated with total prostate cancer (RR = 0.89, 95% CI 0.80–0.98, BMI ≥26 vs. 20–21.9, ptrend = 0.01) and with fatal and advanced disease. The association for late adult BMI differed by age (pinteraction < 0.001); high BMI was inversely associated with total prostate cancer (RR = 0.64, 95% CI 0.51–0.78, BMI ≥30 vs. 21–22.9, ptrend<0.001) and with non‐advanced and less aggressive tumors among men ≤65 years, whereas no association was seen among men >65 years. Adult waist circumference was weakly inversely associated with less aggressive disease. Childhood obesity was unclearly related to risk. Our study confirms tall men to be at increased risk of fatal and advanced prostate cancer. The influence of adiposity varies by prognostic disease subtype and by age. The relationship between body size and prostate cancer is complex. Body size changes progressively throughout life and consequent effects on prostate cancer risk may be associated with related changes in hormonal and metabolic pathways. This large prospective study examined potential associations between the risk of various prostate cancer subtypes and multiple anthropometric measures at different ages in men. Tallness was confirmed to be associated with an elevated risk of advanced prostate cancer, particularly fatal disease. The extent to which body weight influenced risk varied according to factors such as age and disease subtype.
What's new?
The relationship between body size and prostate cancer is complex. In one of the largest prospective studies on men, we examined the association between multiple anthropometric measures at different ages and risk of various prostate cancer subtypes. Our study confirms tall men to be at increased risk of fatal and advanced prostate cancer. We also found that the influence of adiposity varies strongly by age and disease subtype, which is fundamental for future studies.</description><identifier>ISSN: 0020-7136</identifier><identifier>ISSN: 1097-0215</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.29842</identifier><identifier>PMID: 26355806</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Age ; Aged ; Anthropometry ; Body Mass Index ; Body Size - physiology ; Cancer ; childhood body size ; epidemiology ; Follow-Up Studies ; Health risk assessment ; height ; Humans ; Incidence ; Male ; Medical personnel ; Medical research ; Mens health ; Middle Aged ; Proportional Hazards Models ; Prostate cancer ; prostatic neoplasms ; Prostatic Neoplasms - epidemiology ; Risk Factors ; Tumors ; waist circumference ; Young Adult</subject><ispartof>International journal of cancer, 2016-02, Vol.138 (4), p.853-865</ispartof><rights>2015 UICC</rights><rights>2015 UICC.</rights><rights>2016 UICC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.29842$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.29842$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26355806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-40668$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:132859052$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Möller, Elisabeth</creatorcontrib><creatorcontrib>Wilson, Kathryn M.</creatorcontrib><creatorcontrib>Batista, Julie L.</creatorcontrib><creatorcontrib>Mucci, Lorelei A.</creatorcontrib><creatorcontrib>Bälter, Katarina</creatorcontrib><creatorcontrib>Giovannucci, Edward</creatorcontrib><title>Body size across the life course and prostate cancer in the Health Professionals Follow‐up Study</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Current evidence of an association between body size and prostate cancer is conflicting, possibly due to differential effects of body size across the lifespan and the heterogeneity of the disease. We therefore examined childhood and adult body size in relation to total incident prostate cancer and prognostic subtypes in a prospective cohort of 47,491 US men in the Health Professionals Follow‐up Study. We assessed adult height, body mass index (BMI) in early and middle‐to‐late adulthood, adult waist circumference, and body shape at age 10. With follow‐up from 1986 to 2010, we estimated the relative risk (RR) of prostate cancer using Cox proportional hazards models. We identified 6,183 incident cases. Tallness was associated with increased risk of advanced‐stage tumors, particularly fatal disease (RR = 1.66, 95% CI 1.23–2.23, highest vs. lowest quintile, ptrend < 0.001). High BMI at age 21 was inversely associated with total prostate cancer (RR = 0.89, 95% CI 0.80–0.98, BMI ≥26 vs. 20–21.9, ptrend = 0.01) and with fatal and advanced disease. The association for late adult BMI differed by age (pinteraction < 0.001); high BMI was inversely associated with total prostate cancer (RR = 0.64, 95% CI 0.51–0.78, BMI ≥30 vs. 21–22.9, ptrend<0.001) and with non‐advanced and less aggressive tumors among men ≤65 years, whereas no association was seen among men >65 years. Adult waist circumference was weakly inversely associated with less aggressive disease. Childhood obesity was unclearly related to risk. Our study confirms tall men to be at increased risk of fatal and advanced prostate cancer. The influence of adiposity varies by prognostic disease subtype and by age. The relationship between body size and prostate cancer is complex. Body size changes progressively throughout life and consequent effects on prostate cancer risk may be associated with related changes in hormonal and metabolic pathways. This large prospective study examined potential associations between the risk of various prostate cancer subtypes and multiple anthropometric measures at different ages in men. Tallness was confirmed to be associated with an elevated risk of advanced prostate cancer, particularly fatal disease. The extent to which body weight influenced risk varied according to factors such as age and disease subtype.
What's new?
The relationship between body size and prostate cancer is complex. In one of the largest prospective studies on men, we examined the association between multiple anthropometric measures at different ages and risk of various prostate cancer subtypes. Our study confirms tall men to be at increased risk of fatal and advanced prostate cancer. We also found that the influence of adiposity varies strongly by age and disease subtype, which is fundamental for future studies.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Anthropometry</subject><subject>Body Mass Index</subject><subject>Body Size - physiology</subject><subject>Cancer</subject><subject>childhood body size</subject><subject>epidemiology</subject><subject>Follow-Up Studies</subject><subject>Health risk assessment</subject><subject>height</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical personnel</subject><subject>Medical research</subject><subject>Mens health</subject><subject>Middle Aged</subject><subject>Proportional Hazards Models</subject><subject>Prostate cancer</subject><subject>prostatic neoplasms</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Risk Factors</subject><subject>Tumors</subject><subject>waist circumference</subject><subject>Young Adult</subject><issn>0020-7136</issn><issn>1097-0215</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1ks9u1DAQxi1ERZfCgRdAlrj00LRjJ_6TC1LZUtqqEkj8uVp2Mul6ycZLnHS1nHgEnpEnwd1dKorEyaPv-3n0aWYIecHgmAHwEz-vjnmpC_6ITBiUKgPOxGMySR5kiuVynzyNcQ7AmIDiCdnnMhdCg5wQ9ybUaxr9d6S26kOMdJghbX2DtApjH5Pc1XSZnMEOSbNdhT313Qa7QNsOM_qhDw3G6ENn20jPQ9uG1a8fP8cl_TiM9foZ2WuSgc937wH5fP720_Qiu37_7nJ6ep3NUxSeCaEqoZTUGkWhAdGV1upCY6mcyp1DK0rpLDaiRF3UTkFToSx4JRyUooH8gGTbvnGFy9GZZe8Xtl-bYL3ZSV9ThUYw0FAm_ui__Jn_cmpCf2MW9cwUIKVO-OstntgF1hV2Q2_bB78eOp2fmZtwa9LIeV7I1OBw16AP30aMg1n4WGHb2g7DGA1TEkoGgrOEvvoHnadl3I03UUIJEEzniXr5d6L7KH-2m4CTLbDyLa7vfQbm7mxMOhuzORtzeTXdFPlvI4O3Wg</recordid><startdate>20160215</startdate><enddate>20160215</enddate><creator>Möller, Elisabeth</creator><creator>Wilson, Kathryn M.</creator><creator>Batista, Julie L.</creator><creator>Mucci, Lorelei A.</creator><creator>Bälter, Katarina</creator><creator>Giovannucci, Edward</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF7</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20160215</creationdate><title>Body size across the life course and prostate cancer in the Health Professionals Follow‐up Study</title><author>Möller, Elisabeth ; Wilson, Kathryn M. ; Batista, Julie L. ; Mucci, Lorelei A. ; Bälter, Katarina ; Giovannucci, Edward</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j5802-557c577688e5480eeb9aa848e97b73bbea596baef59e84db70fce642c5b095f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Anthropometry</topic><topic>Body Mass Index</topic><topic>Body Size - physiology</topic><topic>Cancer</topic><topic>childhood body size</topic><topic>epidemiology</topic><topic>Follow-Up Studies</topic><topic>Health risk assessment</topic><topic>height</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical personnel</topic><topic>Medical research</topic><topic>Mens health</topic><topic>Middle Aged</topic><topic>Proportional Hazards Models</topic><topic>Prostate cancer</topic><topic>prostatic neoplasms</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Risk Factors</topic><topic>Tumors</topic><topic>waist circumference</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Möller, Elisabeth</creatorcontrib><creatorcontrib>Wilson, Kathryn M.</creatorcontrib><creatorcontrib>Batista, Julie L.</creatorcontrib><creatorcontrib>Mucci, Lorelei A.</creatorcontrib><creatorcontrib>Bälter, Katarina</creatorcontrib><creatorcontrib>Giovannucci, Edward</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Mälardalens högskola</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Möller, Elisabeth</au><au>Wilson, Kathryn M.</au><au>Batista, Julie L.</au><au>Mucci, Lorelei A.</au><au>Bälter, Katarina</au><au>Giovannucci, Edward</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body size across the life course and prostate cancer in the Health Professionals Follow‐up Study</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2016-02-15</date><risdate>2016</risdate><volume>138</volume><issue>4</issue><spage>853</spage><epage>865</epage><pages>853-865</pages><issn>0020-7136</issn><issn>1097-0215</issn><eissn>1097-0215</eissn><abstract>Current evidence of an association between body size and prostate cancer is conflicting, possibly due to differential effects of body size across the lifespan and the heterogeneity of the disease. We therefore examined childhood and adult body size in relation to total incident prostate cancer and prognostic subtypes in a prospective cohort of 47,491 US men in the Health Professionals Follow‐up Study. We assessed adult height, body mass index (BMI) in early and middle‐to‐late adulthood, adult waist circumference, and body shape at age 10. With follow‐up from 1986 to 2010, we estimated the relative risk (RR) of prostate cancer using Cox proportional hazards models. We identified 6,183 incident cases. Tallness was associated with increased risk of advanced‐stage tumors, particularly fatal disease (RR = 1.66, 95% CI 1.23–2.23, highest vs. lowest quintile, ptrend < 0.001). High BMI at age 21 was inversely associated with total prostate cancer (RR = 0.89, 95% CI 0.80–0.98, BMI ≥26 vs. 20–21.9, ptrend = 0.01) and with fatal and advanced disease. The association for late adult BMI differed by age (pinteraction < 0.001); high BMI was inversely associated with total prostate cancer (RR = 0.64, 95% CI 0.51–0.78, BMI ≥30 vs. 21–22.9, ptrend<0.001) and with non‐advanced and less aggressive tumors among men ≤65 years, whereas no association was seen among men >65 years. Adult waist circumference was weakly inversely associated with less aggressive disease. Childhood obesity was unclearly related to risk. Our study confirms tall men to be at increased risk of fatal and advanced prostate cancer. The influence of adiposity varies by prognostic disease subtype and by age. The relationship between body size and prostate cancer is complex. Body size changes progressively throughout life and consequent effects on prostate cancer risk may be associated with related changes in hormonal and metabolic pathways. This large prospective study examined potential associations between the risk of various prostate cancer subtypes and multiple anthropometric measures at different ages in men. Tallness was confirmed to be associated with an elevated risk of advanced prostate cancer, particularly fatal disease. The extent to which body weight influenced risk varied according to factors such as age and disease subtype.
What's new?
The relationship between body size and prostate cancer is complex. In one of the largest prospective studies on men, we examined the association between multiple anthropometric measures at different ages and risk of various prostate cancer subtypes. Our study confirms tall men to be at increased risk of fatal and advanced prostate cancer. We also found that the influence of adiposity varies strongly by age and disease subtype, which is fundamental for future studies.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>26355806</pmid><doi>10.1002/ijc.29842</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 2016-02, Vol.138 (4), p.853-865 |
| issn | 0020-7136 1097-0215 1097-0215 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_510809 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online |
| subjects | Adult Age Aged Anthropometry Body Mass Index Body Size - physiology Cancer childhood body size epidemiology Follow-Up Studies Health risk assessment height Humans Incidence Male Medical personnel Medical research Mens health Middle Aged Proportional Hazards Models Prostate cancer prostatic neoplasms Prostatic Neoplasms - epidemiology Risk Factors Tumors waist circumference Young Adult |
| title | Body size across the life course and prostate cancer in the Health Professionals Follow‐up Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T10%3A12%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Body%20size%20across%20the%20life%20course%20and%20prostate%20cancer%20in%20the%20Health%20Professionals%20Follow%E2%80%90up%20Study&rft.jtitle=International%20journal%20of%20cancer&rft.au=M%C3%B6ller,%20Elisabeth&rft.date=2016-02-15&rft.volume=138&rft.issue=4&rft.spage=853&rft.epage=865&rft.pages=853-865&rft.issn=0020-7136&rft.eissn=1097-0215&rft_id=info:doi/10.1002/ijc.29842&rft_dat=%3Cproquest_swepu%3E1760910521%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1757505183&rft_id=info:pmid/26355806&rfr_iscdi=true |