Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

Mammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds of large lamina-associated domains (LADs). We report a method to map NL contacts genome-wide in single human cells. Analysis of nearly 400 maps reveals a core architecture consisting of gene-poor LADs that contac...

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Veröffentlicht in:	Cell 2015-09, Vol.163 (1), p.134-147
Hauptverfasser:	Kind, Jop, Pagie, Ludo, de Vries, Sandra S., Nahidiazar, Leila, Dey, Siddharth S., Bienko, Magda, Zhan, Ye, Lajoie, Bryan, de Graaf, Carolyn A., Amendola, Mario, Fudenberg, Geoffrey, Imakaev, Maxim, Mirny, Leonid A., Jalink, Kees, Dekker, Job, van Oudenaarden, Alexander, van Steensel, Bas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotechnology Cell Line, Tumor Cellular Biology Chromatin - chemistry Chromatin - metabolism Chromosomes - chemistry Chromosomes - metabolism genes Genome-Wide Association Study Hematology heterochromatin histones Human health and pathology Humans In Situ Hybridization, Fluorescence Interphase Life Sciences loci Nuclear Lamina - metabolism ploidy Single-Cell Analysis - methods
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