Proteolytically active ADAM10 and ADAM17 carried on membrane microvesicles in human abdominal aortic aneurysms

Summary The intraluminal thrombus (ILT) of human abdominal aortic aneurysm (AAA) has been suggested to damage the underlying aortic wall, but previous work found scant activity of soluble proteases in the abluminal layer of the ILT, adjacent to the aneurysm. We hypothesised that transmembrane protea...

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Veröffentlicht in:	Thrombosis and haemostasis 2015, Vol.113 (6), p.1165-1174
Hauptverfasser:	Folkesson, Maggie, Li, Chunjun, Frebelius, Siw, Swedenborg, Jesper, Wågsäter, Dick, Williams, Kevin Jon, Eriksson, Per, Roy, Joy, Liu, Ming-Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	A disintegrin and matrix Abdominal aortic aneurysm ADAM Proteins - metabolism ADAM10 ADAM10 Protein ADAM17 ADAM17 Protein Aged Aged, 80 and over Amyloid Precursor Protein Secretases - metabolism Antigens, CD - analysis Aortic Aneurysm, Abdominal - enzymology Aortic Aneurysm, Abdominal - epidemiology Aortic Aneurysm, Abdominal - etiology Aortic Rupture - enzymology Arterial Occlusive Diseases - enzymology Cell Adhesion Molecules - analysis Cell and Molecular Biology Cell- och molekylärbiologi Cell-Derived Microparticles - enzymology CELLS Coagulation and Fibrinolysis Enzyme Induction EXPRESSION FACTOR-ALPHA Female HL-60 Cells HUMAN ATHEROSCLEROTIC PLAQUES Humans INTRALUMINAL intraluminal thrombus Male Membrane Proteins - metabolism MICROPARTICLES Microscopy, Electron Middle Aged Neutrophils - chemistry Neutrophils - ultrastructure Protein Processing, Post-Translational Risk Smoke - adverse effects Smoking - adverse effects Thrombosis - enzymology Thrombosis - immunology THROMBUS TISSUE FACTOR TOBACCO-SMOKE TUMOR-NECROSIS-FACTOR
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