Platelets made HLA deficient by acid treatment aggregate normally and escape destruction by complement and phagocytes in the presence of HLA antibodies

BACKGROUND The presence of antibodies against HLA Class I can lead to platelet (PLT) transfusion refractoriness, that is, the repeated failure to achieve adequate posttransfusion PLT count increments. PLT refractoriness can be overcome by transfusion of HLA‐matched donor PLTs. A different approach i...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2016-02, Vol.56 (2), p.370-382
Hauptverfasser:	Meinke, Stephan, Sandgren, Per, Mörtberg, Anette, Karlström, Cecilia, Kadri, Nadir, Wikman, Agneta, Höglund, Petter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Blood Platelets - chemistry Blood Platelets - cytology Citric Acid - chemistry Complement System Proteins - chemistry Female HLA Antigens - chemistry Humans Hydrogen-Ion Concentration Immunoglobulins Male Medicin och hälsovetenskap Phagocytes Platelet Aggregation
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