Highly Sensitive FRET-FCS Detects Amyloid β‑Peptide Oligomers in Solution at Physiological Concentrations

Oligomers formed by the amyloid β-peptide (Aβ) are pathogens in Alzheimer’s disease. Increased knowledge on the oligomerization process is crucial for understanding the disease and for finding treatments. Ideally, Aβ oligomerization should be studied in solution and at physiologically relevant conce...

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Veröffentlicht in:Analytical chemistry (Washington) 2015-12, Vol.87 (23), p.11700-11705
Hauptverfasser: Wennmalm, Stefan, Chmyrov, Volodymyr, Widengren, Jerker, Tjernberg, Lars
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Sprache:eng
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