Meta-analysis identifies seven susceptibility loci involved in the atopic march

Eczema often precedes the development of asthma in a disease course called the ‘atopic march’. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations in...

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Veröffentlicht in:	Nature communications 2015-11, Vol.6 (1), p.8804, Article 8804
Hauptverfasser:	Marenholz, Ingo, Esparza-Gordillo, Jorge, Rüschendorf, Franz, Bauerfeind, Anja, Strachan, David P., Spycher, Ben D., Baurecht, Hansjörg, Margaritte-Jeannin, Patricia, Sääf, Annika, Kerkhof, Marjan, Ege, Markus, Baltic, Svetlana, Matheson, Melanie C., Li, Jin, Michel, Sven, Ang, Wei Q., McArdle, Wendy, Arnold, Andreas, Homuth, Georg, Demenais, Florence, Bouzigon, Emmanuelle, Söderhäll, Cilla, Pershagen, Göran, de Jongste, Johan C., Postma, Dirkje S., Braun-Fahrländer, Charlotte, Horak, Elisabeth, Ogorodova, Ludmila M., Puzyrev, Valery P., Bragina, Elena Yu, Hudson, Thomas J., Morin, Charles, Duffy, David L., Marks, Guy B., Robertson, Colin F., Montgomery, Grant W., Musk, Bill, Thompson, Philip J., Martin, Nicholas G., James, Alan, Sleiman, Patrick, Toskala, Elina, Rodriguez, Elke, Fölster-Holst, Regina, Franke, Andre, Lieb, Wolfgang, Gieger, Christian, Heinzmann, Andrea, Rietschel, Ernst, Keil, Thomas, Cichon, Sven, Nöthen, Markus M., Pennell, Craig E., Sly, Peter D., Schmidt, Carsten O., Matanovic, Anja, Schneider, Valentin, Heinig, Matthias, Hübner, Norbert, Holt, Patrick G., Lau, Susanne, Kabesch, Michael, Weidinger, Stefan, Hakonarson, Hakon, Ferreira, Manuel A. R., Laprise, Catherine, Freidin, Maxim B., Genuneit, Jon, Koppelman, Gerard H., Melén, Erik, Dizier, Marie- Hélène, Henderson, A John, Lee, Young Ae
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/144 631/250/249/2510/31 692/1807/1812 692/420 Adaptor Proteins, Vesicular Transport - genetics Adolescent Adult Allergic diseases Amino Acid Transport Systems, Neutral - genetics Asthma Asthma - genetics Atopy Calcium-Binding Proteins - genetics Carrier Proteins - genetics Child Child, Preschool Children Chromosome 12 Chromosome 6 Dermatitis, Atopic - genetics Disease Progression DNA-Binding Proteins - genetics Eczema Female Filaggrin Proteins Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genotype Humanities and Social Sciences Humans Ikaros Transcription Factor - genetics Interleukin 4 Interleukin-4 - genetics Kinesins - genetics Life Sciences Loci Logistic Models Male Membrane Proteins - genetics Meta-analysis Middle Aged multidisciplinary Neoplasm Proteins - genetics Nerve Tissue Proteins - genetics Nuclear Proteins - genetics Phenotype Phenotypes Polymorphism, Single Nucleotide Receptor, Fibroblast Growth Factor, Type 1 - genetics Repressor Proteins - genetics Science Science (multidisciplinary) Skin diseases Statistics Transcription Factors - genetics Young Adult
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